Characterization of the thyroxine-binding site of thyroxine-binding globulin by site-directed mutagenesis

Molecular Endocrinology

Volumn 13, Issue 11, 1999, Pages 1864-1872

  Buettner, Christoph ^a,b   Grasberger, Helmut ^a   Hermansdorfer, Kristine ^a   Chen, Bingkun ^a,c   Treske, Bettina ^a   Janssen, Onno E ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Jiamusi Medical College   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; HYDROCORTISONE; LEUCINE; LYSINE; PHENYLALANINE; SERINE PROTEINASE INHIBITOR; THREONINE; THYROXINE; THYROXINE BINDING GLOBULIN; TRANSCORTIN; TRYPTOPHAN; VALINE;

ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; FEMALE; GLYCOSYLATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

EID: 0033305403     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.11.0367     Document Type: Article

References (42)

1. Role of plasma proteins in the binding, distribution, and metabolism of the thyroid hormones
2. Transport, cellular uptake, metabolism of thyroid hormone
3. Thyroxine-protein interactions. Interaction of thyroxine and triiodothyronine with the human thyroxine-binding globulin
4. Studies on human thyroxine-binding globulin. 8. Isoelectric focusing evidence for microheterogeneity of thyroxine-binding globulin
5. Thyroxine-binding globulin: Investigation of microheterogeneity
6. A surprising new protein superfamily containing ovalbumin, antithrombin-III, and α1-proteinase inhibitor
7. 1-antitrypsin for structure and function of serpins
8. An atlas of serpin conformations
9. 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function
10. Molecular and structural characterization of the heat-resistant thyroxine-binding globulin-Chicago
11. Inherited thyroxine-binding globulin abnormalities in man
12. Molecular basis of inherited thyroxine-binding globulin defects
13. Binding of thyroid hormones and their analogues to thyroxine-binding globulin in human serum
14. Structure of human plasma prealbumin at 2.5 A resolution. A preliminary report on the polypeptide chain conformation, quaternary structure and thyroxine binding
15. Atomic structure and chemistry of human serum albumin
16. Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: Close homology to the serine antiproteases
17. Specific labeling of the thyroxine binding site in thyroxine-binding globulin: Determination of the amino acid composition of a labeled peptide fragment isolated from a proteolytic digest of the derivatized protein
18. Modularity of serpins: A bifunctional chimera possessing a1 -proteinase inhibitor and thyroxine-binding globulin properties
19. Sheep thyroxine-binding globulin: cDNA sequence and expression
20. Molecular cloning and primary structure of rat thyroxine-binding globulin
21. 3 binding to serum proteins
22. Comparison of the modelled thyroxine binding site in TBG with the experimentally determined site in transthyretin
23. Homology model of thyroxine binding globulin and elucidation of the thyroid hormone binding site
24. Binding of mercuri-iodide and related ions to crystals of sperm whale myoglobin
25. Thyroxine-binding globulin: Organization of the gene and variants
26. Misfolding and aggregation of newly synthesized proteins in the endoplasmatic reticulum
27. Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport
28. The amino acid at the position of an Asn-X-Ser Sequon is an important determinant of N-linked core-glycosylation efficiency
29. Effects of glycosylation on the folding and stability of human, recombinant and cleaved α1-antitrypsin
30. Crystal structure of ovalbumin as a model for the reactive center of serpins
31. Glycosylation of human corticosteroid-binding globulin at asparagine 238 is necessary for steroid binding
32. Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites
33. -113
34. DNA sequencing with chain terminating inhibitors
35. Translation of eukaryotic messenger RNA in Xenopus oocytes
36. Use of microinjection techniques to study protein kinases and protein phosphorylation in amphibian oocytes
37. Oogenesis in Xenopus laevis (Daudin): Stages of oocyte development in laboratory maintained animals
38. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
39. Variant thyroxine-binding globulin in serum of Australian Aborigines: Its physical, chemical and biological properties
40. The attractions of proteins for small molecules and ions
41. Cell membrane antigen isolation with the Staphylococcal Protein A-antibody adsorbent
42. Radioimmunoassays specific for the tertiary and primary structures of thyroxine-binding globulin (TBG): Measurement of denatured TBG in serum