A β-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for α-adaptin association

Molecular Endocrinology

Volumn 13, Issue 11, 1999, Pages 1823-1831

  Vleurick, Lieve ^a,b,c   Pezet, Alain ^a   Kühn, Eduard R ^b   Decuypere, Eddy ^b   Edery, Marc ^a  

^a INSERM   (France)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c NONE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALPHA ADAPTIN; ASPARTIC ACID; GLUTAMINE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; JANUS KINASE; PROLINE; STAT5 PROTEIN; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CERCOPITHECIDAE; CONTROLLED STUDY; ENDOCYTOSIS; FIBROBLAST; GENETIC TRANSCRIPTION; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 0033305042     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.11.0371     Document Type: Article

References (40)

1. Cytokine receptor signalling through two novel families of transducer molecules: Janus kinases, and signal transducers and activators of transcription
2. Identification of circulating growth hormone-binding proteins in domestic poultry: An initial characterization
3. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
4. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
5. Polypeptide hormones: Intracellular receptors and internalization
6. The role of clathrin, adaptors and dynamin in endocytosis
7. Signal-dependent membrane protein trafficking in the endocytic pathway
8. Linking cargo to vesicle formation: Receptor tail interactions with coat proteins
9. Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation
10. Identification of cytoplasmatic motifs required for short prolactin receptor internalization
11. Effect of hypophysectomy and acute administration of growth hormone (GH) on GH-receptor binding in chick liver membranes
12. Intracellular growth hormone receptors in chicken liver
13. Molecular cloning of the chicken growth hormone receptor complementary deoxyribonucleic acid: Mutation of the gene in sex-linked dwarf chickens
14. A decreased capacity of hepatic growth hormone (GH) receptors and failure of thyrotrophin-releasing hormone to stimulate the peripheral conversion of thyroxine into triiodothyronine in sex-linked dwarf broiler hens
15. Molecular biology of the chicken growth hormone receptor
16. Cytoplasmatic sequences of the growth hormone receptor necessary for signal transduction
17. Emperical predictions of protein conformation
18. Monkey growth hormone (GH) receptor gene expression: Evidence for two mechanisms for the generation of the GH binding protein
19. The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor
20. N-Glycosylation of the prolactin receptor is not required for activation of gene transcription but is crucial for its cell surface targeting
21. Grb 10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target protein
22. A new protein containing an SH2 domain that inhibits JAK kinases
23. Prolactin receptor regulates STAT5 tyrosine phosphorylation and nuclear translocation by two separate pathways
24. Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation
25. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
26. Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugated system
27. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
28. 974-containing internalization motif
29. 2-adrenergic receptor
30. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor
31. Linkage of the ubiquitin-conjugating system and the endocytic-pathway in ligand-induced internalization of the growth hormone receptor
32. Generation of chicken growth hormone-binding proteins by proteolysis
33. Evidence for generation of the growth hormone-binding protein through proteolysis of growth hormone membrane receptor
34. One-step purification of chicken growth hormone from a crude pituitary extract by use of a monoclonal immunoadsorbent
35. Estimation of total prolactin-binding sites after in vitro desaturation
36. Overexpression of a truncated growth hormone receptor in the sex-linked dwarf chicken: Evidence for a splice mutation
37. Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells
38. DNA sequencing with chain terminating inhibitors
39. LIGAND: A versatile computerized approach for characterization of ligand-binding systems
40. Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor