Effects of oxazepam and acetaminophen on cicletanine metabolism in rat hepatocytes and liver microsomes

Fundamental and Clinical Pharmacology

Volumn 13, Issue 5, 1999, Pages 571-576

  Menard, Christophe ^a   Lamiable, Denis ^b   Vistelle, Richard ^b   Droy Lefait, Marie Thérèse ^c   Ratanasavanh, Damrong ^a  

^a FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

^b UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^c IPSEN   (France)

Author keywords

Cicletanine; Conjugation; Drug interactions; Metabolism

Indexed keywords

CICLETANINE; OXAZEPAM; PARACETAMOL;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIURETIC ACTIVITY; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG TRANSFORMATION; LIVER METABOLISM; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033304140     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1999.tb00363.x     Document Type: Article

References (21)

1. Reduction by (-)-cicletanine of the vascular reactivity to angiotansin II in rat
2. Evidence for (+)-cicletanine sulfate as an active natriuretic metabolite of cicletanine in the rat
3. Urinary excretion of cicletanine in the rat. Stereochemical aspects
4. Multiple dose pharmacokinetic study of cicletanine in healthy volunteers
5. Methods for preparation of adult and foetal hepatocytes
6. Evidence for the involvement of several cytochrome P450 in the first-step of caffeine metabolism by human liver microsomes
7. Cicletanine
8. On-column enantiomerization of 3-hydrobenzodiazepine during chiral liquid chromatography with optical rotation detection
9. (S) Oxazepam glucuronidation is inhibited by ketoprofen and other substrates of UGT2B7
10. Benzodiazepine for alcohol withdrawal in the elderly and in patients with liver disease
11. Detoxification: The use of benzodiazepines
12. Genetic and environmental factors associated with variations of human xenobiotic glucuronidation and sulfation
13. Paracetamol metabolism in two ethnically different Spanish populations
14. Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocytes
15. Effect of polysaccharide peptide (PSP) on in vivo sulphation and glucuronidation of paracetamol in the rat
16. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics
17. The effect of probenecid on paracetamol metabolism and pharmacokinetics
18. Regulation of sulphation and glutathione conjugation of acetaminophen in isolated rat hepatocytes
19. Purification and immunochemical characterization of a rat liver sulphotransferase conjugating paracetamol
20. The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine and paracetamol as probes
21. Aryl sulfotranferases