Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder

Bipolar Disorders

Volumn 1, Issue 2, 1999, Pages 81-86

  Hahn, Chang Gyu ^a   Friedman, Eitan ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Bipolar disorder; Intracellular signaling; Kinase C; Protein

Indexed keywords

LITHIUM DERIVATIVE; PROTEIN KINASE C; TRANQUILIZER;

ANIMAL; BIPOLAR DISORDER; CASE CONTROL STUDY; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; RAT; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE; UPREGULATION;

ANIMALS; ANTIMANIC AGENTS; BIPOLAR DISORDER; BLOOD PLATELETS; CASE-CONTROL STUDIES; HUMANS; LITHIUM COMPOUNDS; PHOSPHORYLATION; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 0033301364     PISSN: 13985647     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-5618.1999.010204.x     Document Type: Review

References (32)

1. Dubovsky SL, Christiano J, Daniell LC, Franks RD, Murphy J, Adler L, Baker N, Harris A. Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 1989; 46: 632-638.
2. Dubovsky SL, Murphy J, Thomas K, Rademacher J. Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 1992; 149: 118-120.
3. Shreiber G, Avissar S, Danon A, Belmaker RH. Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry 1991; 29: 273-280.
4. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 1988; 334: 661-665.
5. Parker PJ, Coussens L, Totty N, Rhee L, Young S, Chen E, Stabel S, Waterfield MD, Ullrich A. The complete primary structure of protein kinase C - the major phorbol ester receptor. Science 1986; 233: 853-859.
6. Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 1986; 233: 859-866.
7. Ono Y, Kurokawa T, Fujii T, Kawahar K, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y. Two types of complementary DNAs of rat brain protein kinase. FEBS Lett 1986; 206 (2): 347-352.
8. Ono Y, Fujii T, Ojita K, Kikkawa U, Igarashi K, Nishizuka Y. The structure, expression, and properties of additional members of the protein kinase C family. J Biol Chem 1988; 263 (14): 6927-6932.
9. Worley PF, Baraban JM, Snyder SH. Heterogeneous localization of protein kinase C in rat brain: autoradiographic analysis of phorbol ester receptor binding. J Neurosci 1966; 6 (1): 199-207.
10. Saito N, Kikkawa U, Nishizuka Y, Tanaka C. Distribution of protein kinase C-like immunoreactive neurons in rat brain. J Neurosci 1988; 8 (2): 369-382.
11. Kraft AS, Anderson WB. Phorbol esters increase the amount of calcium, phospholipid-dependent protein kinase associated with plasma membrane. Nature 1983; 301: 621-623.
12. Mochly-Rosen D, Khaner H, Lopez J. Identification of intracellular receptor proteins for activated protein kinase C. PNAS 1991; 88 (9): 3997-4000.
13. Wang H-Y, Friedman E. Lithium inhibition of protein kinase C activation-induced serotonin release. Psychopharmacology 1989; 99 (2): 213-218.
14. Weiss S, Ellis J, Hendley DD, Lenox RH. Translocation and activation of protein kinase C in striatal neurons in primary culture: relationship to phorbol dibutyrate actions on the inositol phosphate generating system and neurotransmitter release. J Neurochem 1989; 52: 530-536.
15. Bitran JA, Potter WZ, Manji HK, Gusovsky F. Chronic Li attenuates agonist-and phorbol ester-mediated NA + /H + antiporter activity in HL-60 cells. Eur J Pharmacol Mol Pharmacol Sec 1990; 188: 193-202.
16. Manji HK, Etchberrigaray R, Chen G, Olds JL. Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the a isozyme. J Neurochem 1993; 61: 2303-2310.
17. Chen G, Manji HK, Hawver DB, Wright CB, Potter WZ. Chronic sodium valproate selectively decreases protein kinase C α and ε in vitro. J Neurochem 1994; 63: 2361-2364.
18. Lenox RH, Watson DG, Patel J, Ellis J. Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res 1992; 570: 333-340.
19. Manji HK, Bebchuk JM, Chen G. Protein kinase C signaling cascade: molecular transduction of mood stabilization in the treatment of bipolar disorder. ACNP 1997; 80.
20. Friedman E, Wang H-Y, Levinson D, Connell TA, Singh H. Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol Psychiatry 1993; 33: 520-525.
21. Wang H-Y, Markowitz P, Levinson D, Undie AS, Friedman E. Increased membrane-associated protein kinase C activity and translocation in blood platelets from bipolar affective disorder patients. J Psychiatr Res 1998; 33: 171-179.
22. Wang H-Y, Friedman E. Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. Biol Psychiatry 1996; 40: 568-575.
23. Friedman E, Wang HY. Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. J Neurochem 1996; 67: 1145-1152.
24. Mathews R, Li PP, Trevor Young L, Kish SJ, Warsh JJ. Increased G q/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder. Biol Psychiatry 1997; 41: 649-656.
25. Brown AS, Mallinger AG, Renbaum LC. Elevated platelet membrane phosphatidyl inositol-4,5-bisphosphate in bipolar mania. Am J Psychiatry 1993; 150: 1252-1254.
26. Avissar S, Schreiber G, Danon A, Belmaker RH. Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex. Nature 1988; 331: 440-442.
27. Manji HK, Chen G, Shimon H, Hsiao JK, Potter WZ, Belmaker RH. Guanine nucleotide-binding proteins in bipolar affective disorder. Arch Gen Psychiatry 1995; 52: 135-144.
28. Wang HY, Friedman E. Effect of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes. Neuropharmacology 1997; 38: 403-414.
29. + response in neurtophils of manic-depressive patients: effect of lithium therapy. Neuropsychobiology 1993; 27: 180-183.
30. Warsh J, Mathews R, Young LT, Li PP. Brain G q/11 and phospholipase C-β1 immunoreactivty in bipolar affective disorder (BD). Can J Physiol Pharmacol 1994; 72: 545.
31. Jope RS, Ling S, Li PP, Trevor Young L, Kish SJ, Pacheco MA, Warsh JJ. The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. J Neurochem 1996; 66: 2402-2409.
32. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607-614.