Heterotopic ossification: Diagnosis and management, current concepts and controversies

Journal of Spinal Cord Medicine

Volumn 22, Issue 4, 1999, Pages 273-283

  Subbarao, Jay V ^a,b,c   Garrison, Susan J ^d,e  

^a HINES VA HOSPITAL   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Diagnosis; Heterotopic ossification; Management

Indexed keywords

HETEROTOPIC OSSIFICATION; HUMAN; JOINT; PARALYSIS; PATHOLOGY; REVIEW; RISK FACTOR; SPINAL CORD INJURY; TREATMENT OUTCOME;

HUMANS; JOINTS; OSSIFICATION, HETEROTOPIC; PARALYSIS; RISK FACTORS; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 0033290479     PISSN: 10790268     EISSN: None     Source Type: Journal    
DOI: 10.1080/10790268.1999.11719580     Document Type: Article

References (79)

1. Dejerine Mme, Cecillier A. Para-osteoarthropathies des parapleguques par lesion medullaire: (etude clinique et radiographique). Ann Med. 1918;5:497-535.
2. Riedel B. Demonstration line durch ach Hagiges Umhergehen total destruirten kniegelnkes von einem pantienten mit stichverletzing des ruckans. Verh Dtsch Gesellschaft Chirurg. 1883;12:93.
3. Garland DE. A clinical perspective on common forms of acquired heterotopic ossification. Clin Orthop. 1991;263:13-29.
4. Rosenfeld SR, Kaplan FS. Progressive osseous heteroplasia in male patients. Two new care reports. Clin Orthop. 1995;317:243-245.
5. Stover SL, Hataway CJ, Zeiger HE. Heterotopic ossification in spinal cord-injured patients. Arch Phys Med Rehabil. 1975;56:199-204.
6. Damanski M. Heterotopic ossification in paraplegia: A clinical study. J Bone Joint Surg Br. 1961;43:286-299.
7. Garland DE, Shimoyama ST, Lugo C, Barras D, Gilgoff I. Spinal cord insults and heterotopic ossification in the pediatric population. Clin Orthop. 1989;245:303-310.
8. Hardy AG, Dickson JW. Pathological ossification in traumatic paraplegia. J Bone Joint Surg Br. 1963;45:76-87.
9. Hernandez AM, Forner JV, Fuente T, Gonzalez C, Miro R. The para-articular ossifications in our paraplegics and tetraplegics: A survey of 704 patients. Paraplegia. 1978;16:272-275.
10. Hossack DW, King A. Neurogenic heterotopic ossification. Med J Aust. 1967;1:326-328.
11. Hsu JD, Sakimura I, Stauffer ES. Heterotopic ossification around the hip joint in spinal cord injured patients. Clin Orthop. 1975;112:165-169.
12. Freehafer AA, Yurick R, Mast WA. Para-articular ossification in spinal cord injury. Med Serv J Can. 1966;22:471-478.
13. Stover SL. Heterotopic ossification after spinal cord injury. In: Bloch RF, Basbaum M, eds. Management of spinal cord injuries. Baltimore: Williams & Wilkins, 1986.
14. Tibone J, Sakimura I, Nickel VL, Hsu JD. Heterotopic ossification around the hip in spinal cord-injured patients: A long-term follow-up study. J Bone Joint Surg Am. 1978;60:769-775.
15. Wharton GW, Morgan TH. Ankylosis in the paralyzed patient. J Bone Joint Surg Am. 1970;52:105-112.
16. Garland DE. Clinical observations on fractures and heterotopic ossification in the spinal cord and traumatic brain injured populations. Clin Orthop. 1988;233:86-101.
17. Kewalramani LS. Ectopic ossification. Am J Phys Med. 1977;56:99-121.
18. Scher AT. The incidence of ectopic bone formation in post-traumatic paraplegic patients of different racial groups. Paraplegia. 1976;14:202-206.
19. Lal S, Hamilton BB, Heinemann A, Betts HB. Risk factors for heterotopic ossification in spinal cord injury. Arch Phys Med Rehabil. 1989;70:387-390.
20. Bravo-Payno P, Esclarin A, Arzoz T, Arroyo O, Labarta C. Incidence and risk factors in the appearance of heterotopic ossification in spinal cord injury. Paraplegia. 1992;30:740-745.
21. Larson JM, Michalski JP, Collacott EA, Eltorai D, McCombs CC, Madorsky JB. Increased prevalence of HLA-B27 in patients with ectopic ossification following traumatic spinal cord injury. Rheumatol Rehabil. 1981;20:193-197.
22. Minaire P, Betuel H, Girard R, Pilonchery G. Neurologic injuries, paraosteoarthropathies, and human leukocyte antigens. Arch Phys Med Rehabil. 1980;61:214-215.
23. Weiss S, Grosswasser A, Ohri A, et al. Histocompatibility (HLA) antigens in heterotopic ossification associated with neurological injury. J Rheumatol. 1979;6:88-91.
24. Hunter T, Dubo HIC, Hildahl CR, Smith NJ, Schroeder ML. Histocompatibility antigens in patients with spinal cord injury or cerebral damage complicated by heterotopic ossification. Rheumatol Rehabil. 1980;19:97-99.
25. Seignalet J, Moulin M, Pelissier J, et al. HLA and neurogenic paraosteoarthropathies. Tissue Antigens. 1983;21:268-269.
26. Garland DE, Alday B, Venos KG. Heterotopic ossification and HLA antigens. Arch Phys Med Rehabil. 1984;65:531-532.
27. Meythaler JM, Tuel SM, Cross LL, Mathew MM. Heterotopic ossification of the extensor tendons in the hand associated with traumatic spinal cord injury. J Am Paraplegia Soc. 1992;15:229-231.
28. Michelsson JE, Rauschning W. Pathogenesis of experimental heterotopic bone formation following temporary forcible exercising of immobilized limbs. Clin Orthop. 1983;176:265-272.
29. Michelsson JE, Granroth G, Andersson LC. Myositis ossificans following forcible manipulation of the leg. A rabbit model for the study of heterotopic bone formation. J Bone Joint Surg. 1980;62:811-815.
30. Friedenstein AJ, Piatezky-Shapiro J, Petrakova KV. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol. 1966;16:381-390.
31. Wlodarski KH. Bone histogenesis mediated by nonosteogenic cells. Clin Orthop. 1991;272:8-15.
32. Ostrowski K, Wlodarski K. Induction of the heterotopic bone formation. In: Bourne GH, ed. The biochemistry and physiology of bone. Vol 3, New York: Academic Press 1971.
33. Urist MR, Nakagawa M, Nakata N, Nogami H. Experimental myositis ossificans. Cartilage and bone formation in muscle in response to a diffusible bone matrix-derived morphogen. Arch Pathol Lab Med. 1978;102:312-316.
34. Ekelund A, Brosjo O, Nilsson OS. Experimental induction of heterotopic bone. Clin Orthop. 1991;263:102-112.
35. Renfree KJ, Banovac K, Hornicek FJ, Lebwohl NH, Villanueva PA, Nedd KJ. Evaluation of serum osteoblast mitogenic activity in spinal cord and head injury patients with acute heterotopic ossification. Spine. 1994;19:740-746.
36. Silver JR. Heterotopic ossification. A clinical study of its possible relationship to trauma. Paraplegia. 1969;7:220-230.
37. Snoecx M, De Muynck M, Van Laere M. Association between muscle trauma and heterotopic ossification in spinal cord injured patients: Reflections on their causal relationship and the diagnostic value of ultrasonography. Paraplegia. 1995;33:464-468.
38. Yarkony GM, Lee MY, Green D, Roth EJ. Heterotopic ossification pseudophlebitis. Am J Med. 1989;87:342-344.
39. Perkash A, Sullivan G, Toth L, Bradleigh LH, Linder SH, Perkash I. Persistent hypercoagulation associated with heterotopic ossification in patients with spinal cord injury long after injury has occurred. Paraplegia. 1993;31:653-659.
40. Haselkorn JK, Britell CW, Cardenas DD. Diagnostic imaging of heterotopic ossification with coexistent deep-venous thrombosis in flaccid paraplegia. Arch Phys Med Rehabil. 1991;72:227-229.
41. Furman R, Nicholas JJ, Jivoff L. Elevation of the serum alkaline phosphatase coincident with ectopic-bone formation in paraplegic patients. J Bone Joint Surg Am. 1970;52:1131-1137.
42. Nicholas JJ. Ectopic bone formation in patients with spinal cord injury. Arch Phys Med Rehabil. 1973;54:354-359.
43. Chantraine A, Minaire P. Para-osteoarthropathies. A new theory and mode of treatment. Scand J Rehabil Med. 1981;13:31-37.
44. Klein L, Van Den Noort S, DeJak JJ. Sequential studies of urinary hydroxyproline and serum alkaline phosphatase in acute paraplegia. Med Serv J Can. 1966;22:524-533.
45. Mysiw WJ, Tan J, Jackson RD. Heterotopic ossification. The utility of osteocalcin in diagnosis and management. Am J Phys Med Rehabil. 1993;72:184-187.
46. Freed JH, Hahn H, Menter R, Dillon T. The use of the three-phase bone scan in the early diagnosis of heterotopic ossification (HO) and in the evaluation of Didronel therapy. Paraplegia. 1982;20:208-216.
47. Orzel JA, Rudd TG. Heterotopic bone formation: Clinical, laboratory, and imaging correlation. J Nucl Med. 1985;26:125-132.
48. Prakash V, Lin MS, Perkash I. Detection of heterotopic calcification with 99mTc-pyrophosphate in spinal cord injury patients. Clin Nucl Med. 1978;3:167-169.
49. Suzuki Y, Hisada K, Takeda M. Demonstration of myositis ossificans by 99mTc pyrophosphate bone scanning. Radiology. 1974;111:663-664.
50. Tanaka T, Rossier AB, Hussey RW, Ahnberg DS, Treves S. Quantitative assessment of para-osteoarthropathy and its maturation on serial radionuclide bone images. Radiology. 1977;123:217-221.
51. Subbarao JV, Nemchausky B A, Gratzer M. Resection of heterotopic ossification and Didronel therapy - regaining wheelchair independence in the spinal cord injured patient. J Am Paraplegia Soc. 1987;10:3-7.
52. Vento JA, Sziklas JJ, Spencer RP, Rosenberg RJ. "Reactivation" of Tc-99m MDP uptake in heterotopic bone. Clin Nucl Med. 1985;10:206-207.
53. Finerman GA, Stover SL. Heterotopic ossification following hip replacement or spinal cord injury. Two clinical studies with EHDP. Metab Bone Dis Relat Res. 1981;3;337-342.
54. Bressler EL, Marn CS, Gore RM, Hendrix RW. Evaluation of ectopic bone by CT. Am J Roentgenol. 1987;148:931-935.
55. Rossier AB, Bussat P, Infante F, et al. Current facts on para-osteo-arthropathy (POA). Paraplegia. 1973;11:36-78.
56. Van der Linden AJ. Spontaneous regression of neurogenic heterotopic ossification. Int Orthop. 1984;8:25-27.
57. Stover SL, Hahn HR, Miller JM III. Disodium etidronate in the prevention of heterotopic ossification following spinal cord injury (preliminary report). Paraplegia. 1976;14:146-156.
58. Stover SL, Niemann KM, Miller JM III. Disodium etidronate in the prevention of postoperative recurrence of heterotopic ossification in spinal-cord injury patients. J Bone Joint Surg Am. 1976;58:683-688.
59. Russell RG, Smith R. Diphosphonates. Experimental and clinical aspects. J Bone Joint Surg Br. 1973;55:66-86.
60. Garland DE, Alday B, Venos KG, Vogt JC. Diphosphonate treatment for heterotopic ossification in spinal cord injury patients. Clin Orthop. 1983;176:197-200.
61. Nollen AJ. Effects of ethylhydroxydiphosphonate (EHDP) on heterotopic ossification. Acta Orthop Scand. 1986;57:358-361.
62. Lindholm TS, Bauer FC, Rindell K. High doses of the diphosphonate EHDP for the prevention of heterotopic ossification: An experimental and clinical study. Scand J Rheumatol. 1987;16:33-39.
63. Flora L, Hassing GS, Cloyd GG, Bevan JA, Parfitt MA, Villanueva AR. The long-term skeletal effects of EHDP in dogs. Metab Bone Dis Relat Res. 1981;3:289-300.
64. Banovac K, Gonzalez F, Wade N, Bowker JJ. Intravenous disodium etidronate therapy in spinal cord injury patients with heterotopic ossification. Paraplegia. 1993;31:660-666.
65. Banovac K, Gonzales F, Renfree KJ. Treatment of heterotopic ossification after spinal cord injury. J Spinal Cord Med. 1997;20(1):60-65.
66. Ayers DC, Pelligrini VD Jr, Evarts CM. Prevention of heterotopic ossification in high-risk patients by radiation therapy. Clin Orthop. 1991;263:87-93.
67. Meiners T, Abel R, Bohm V, Gerner HJ. Resection of heterotopic ossification of the hip in spinal cord injured patients. Spinal Cord. 1997;35(7):443-445.
68. McAuliffe JA, Wolfson AH. Early excision of heterotopic ossification about the elbow followed by radiation therapy. J Bone Joint Surg Am. 1997;79(5):749-755.
69. Freebourn TM, Barber DB, Able AC. The treatment of immature heterotopic ossification in spinal cord injury with combination surgery, radiation therapy and NSAID. Spinal Cord. 1999;37:50-53.
70. Schaeffer MA, Sosner J. Heterotopic ossification: Treatment of established bone with radiation therapy. Arch Phys Med Rehabil. 1995;76:284-286.
71. Crawford CM, Varghese G, Mani MM, Neff JR. Heterotopic ossification: Are range of motion exercises contraindicated? J Burn Care Rehabil. 1986;7:323-327.
72. Subbarao JV. Pseudoarthrosis in heterotopic ossification in spinal cord-injured patients. Am J Phys Med Rehabil. 1990;69:88-90.
73. Garland DE, Razza BE, Waters RL. Forceful joint manipulation in head-injured adults with heterotopic ossification. Clin Orthop. 1982;169:133-138.
74. Wainapel SF, Rao PU, Schepsis AA. Ulnar nerve compression by heterotopic ossification in a head-injured patient. Arch Phys Med Rehabil. 1985;66:512-514.
75. Stover SL, Niemann KM, Tulloss JR. Experience with surgical resection of heterotopic bone in spinal cord injury patients. Clin Orthop. 1991:263;71-77.
76. Frischhut B, Stockhammer G, Saltuari L, Kadletz R, Bramanti P. Early removal of periarticular ossification in patients with head injury. Acta Neurol. 1993;15:114-122.
77. Garland DE, Orwin JF. Resection of heterotopic ossification in patients with spinal cord injuries. Clin Orthop. 1989;242:169-176.
78. Armstrong-Ressy CT, Weiss AA, Ebel A. Results of surgical treatment of extraneous ossifications in spinal cord injuries. Proc Annu Clin Paraplegia Conf. 1957;6:22.
79. Grabois M, Garrison SJ, Hart KA, Lehmkuhl LD. Physical medicine and rehabilitation: A complete approach. In Subbarao JV, ed. Heterotopic Ossification: Diagnosis and Management. Boston, Mass: Blackwell Science Inc., 1999.