Uncompetitive inhibitors of alcohol dehydrogenases

Advances in Experimental Medicine and Biology

Volumn 463, Issue , 1999, Pages 295-303

  Plapp, B V ^a   Chadha, V K ^a   Leidal, K G ^a   Cho, H ^a   Scholze, M ^a   Schindler, J F ^a   Berst, K B ^a   Ramaswamy, S ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 BUTYLTHIOLANE 1 OXIDE; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE INHIBITOR; ENZYME INHIBITOR; N BENZYLFORMAMIDE; N CYCLOHEXYLFORMAMIDE; N CYCLOHEXYLMETHYLFORMAMIDE; N CYCLOPENTYL N CYCLOBUTYLFORMAMIDE; N CYCLOPENTYL N CYCLOPROPYLFORMAMIDE; N FORMYLPIPERIDINE; N HEPTYLFORMAMIDE; N METHYLHEPTYLFORMAMIDE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0033282785     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4735-8_36     Document Type: Conference Paper

References (25)

1. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism
2. Inhibition of liver alcohol dehydrogenase and ethanol metabolism by 3-substituted thiolane 1-oxides
3. Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides
4. Specificity of alcohol dehydrogenases for sulfoxides
5. Statistical analysis of enzyme kinetic data
6. New inhibitors of alcohol dehydrogenase: Studies in vivo and in vitro in the rat
7. Alcohol Dehydrogenases
8. Design of inhibitors from the three-dimensional structure of alcohol dehydrogenase. Chemical synthesis and enzymatic properties
9. Structures of three human β alcohol dehydrogenase variants. Correlations with their functional differences
10. Three-dimensional structures of human alcohol dehydrogenase enzymes reveal the molecular basis for their functional diversity
11. Antidotes for methanol and ethylene glycol poisoning
12. Improved methods for binding protein models in electron density maps and the location of errors in these models
13. Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver enzymes
14. Alcohol oxidation in rats inhibited by pyrazole, oximes and amides
15. Kinetics of inhibition of ethanol metabolism in rats and the rate-limiting role of alcohol dehydrogenase
16. Liver alcohol dehydrogenase inhibition by fatty acid amides, N-alkylformamides and monoalkylureas
17. Binding of formamides to liver alcohol dehydrogenase
18. The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene
19. Inhibition of human alcohol dehydrogenases by formamides
20. Alternative pathways and reactions of benzyl alcohol and benzaldehyde with horse liver alcohol dehydrogenase
21. 2 alcohol dehydrogenase affect hydride transfer and coenzyme dissociation rate constants
22. Progressive sequence alignment and molecular evolution of the Zn-containing alcohol dehydrogenase family
23. Dissociation constants of ternary complexes of fatty acids and fatty acid amides with horse liver alcohol dehydrogenase-coenzyme complexes
24. X-ray structure for human class IV σ σ alcohol dehydrogenase. Structural basis for substrate specificity