Co-increase of Nerve Fibers and HLA-DR-and/or Factor-XIIIa-expressing Dendritic Cells in Dentinal Caries-affected Regions of the Human Dental Pulp: An Immunohistochemical Study

Journal of Dental Research

Volumn 78, Issue 10, 1999, Pages 1596-1608

  Sakurai, K ^a   Okiji, T ^a   Suda, H ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Dental caries; Human dental pulp; Immunohistochemistry; Nerve fibers; Pulpal dendritic cells

Indexed keywords

HLA DR ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

COMPARATIVE STUDY; CONFERENCE PAPER; DENDRITIC CELL; DENSITOMETRY; DENTAL CARIES; DENTIN; ENZYME IMMUNOASSAY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOMODULATION; INSTRUMENTATION; MANDIBLE; MAXILLA; METABOLISM; METHODOLOGY; MOLAR TOOTH; NERVE FIBER; NONPARAMETRIC TEST; STATISTICS; TOOTH PULP;

DENDRITIC CELLS; DENSITOMETRY; DENTAL CARIES; DENTAL PULP; DENTIN; HLA-DR ANTIGENS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; MANDIBLE; MAXILLA; MOLAR; NERVE FIBERS; NEUROIMMUNOMODULATION; STATISTICS, NONPARAMETRIC; TRANSGLUTAMINASES;

EID: 0033278075     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/00220345990780100401     Document Type: Article

References (47)

1. Abello J, Kaiserlian D, Cuber JC, Revillard JP, Chayvialle JA (1991). Characterization of calcitonin gene-related peptide receptors and adenylate cyclase response in the murine macrophage cell line P388 Dl. Neuropeptides 19:43-49
2. Akai M, Wakisaka S (1990). The distribution of peptidergic nerves. In: Dynamic aspects of dental pulp. Inoki R, Kudo T, Olgart LM, editors. London, UK: Chapman and Hall, pp. 337-348.
3. Arai H (1991). Neurohistological study of responses of nerve fibers to pulpitis in human teeth (in Japanese). Jpn J Conseru Dent 34:1631-1645.
4. Bergenholtz G (1989). Bacterial leakage around dental restorations-impact on the pulp. In: Quality evaluation of dental restorations. Anusavice KJ, editor. Lombard, IL: Quintessence Publishing Co., pp. 243-254.
5. Byers MR (1994). Dynamic plasticity of dental sensory nerve structure and cytochemistry. Arch Oral Biol 39:13S-21S.
6. Byers MR, Swift ML, Wheeler EF (1992a). Reactions of sensory nerves to dental restorative procedures. Proc Finn Dent Soc 88:73-82.
7. Byers MR, Wheeler EF, BothweU M (1992b). Altered expression of NGF and P75 NGF-receptor by fibroblasts of injured teeth precedes sensory nerve sprouting. Growth Factors 6:41-52.
8. Eglezos A, Andrews PV, Boyd RL, Helme RD (1991). Modulation of the immune response by tachykinins. Immunol Cell Biol 69:285-294.
9. Fristad I, Heyeraas KJ, Kvinnsland IH, Jonsson R (1995). Recruitment of immunocompetent cells after dentinal injuries in innervated and denervated young rat molars: an immuno-histochemical study. J Histochetn Cytochem 43:871-879.
10. Hahn CL, Falkler WA Jr, Siegel MA (1989). A study of T and B cells in pulpal pathosis. J Endodont 15:20-26.
11. Hama T, Kushima Y, Miyamoto M, Kubota M, Takei N, Hatanaka H (1991). Interleukin-6 improves the survival of mesencephalic catccholaminergic and septal cholincrgic neurons from postnatal, two-week-old rats in cultures. Neuroscience 40:445-152.
12. Hartung HP, Wolters K, Toyka KV (1986). Substance P: binding properties and studies on cellular responses in guinea pig macrophages. J Immunol 136:3856-3863.
13. Heyeraas KJ, Kirn S, Raab WH, Byers MR, Liu M (1994). Effect of electrical tooth stimulation on blood flow, interstitial fluid pressure and substance P and CGRP-immunoreactive nerve fibers in the low compliant cat dental pulp. Microvasc Res 47:329-343.
14. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, et al. (1993). Regulation of Langerhans cell function by nerves containing cakitonin gene-related peptide. Nature 363:159-163.
15. Hsu SM, Raine L, Fanger H (1981). Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580.
16. Izumi T, Kobayashi I, Okamura K, Sakai H (1995). Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth. Arch Oral Biol 40:609-614.
17. Izumi T, Kobayashi I, Okamura K, Matsuo K, Kiyoshima T, Ishibashi Y, et al. (1996). An immunohistochemical study of HLA-DR and alpha 1-antichymorrypsin-positive cells in the pulp of human non-carious and carious teeth. Arch Oral Biol 41:627-630.
18. Jontell M, Gunraj MN, Bergenholtz G (1987). Immunocompetent cells in the normal dental pulp. J Dent Res 66:1149-1153.
19. Jontell M, Eklöf C, Dahlgren UI, Bergenholtz G (1994). Difference in capacity between macrophages and dendritic cells from rat incisor pulp to provide accessory signals to concanavalin-A-stimulated T-lymphocytes. J Dent Res 73:1056-1060.
20. Jontell M, Okiji T, Dahlgren U, Bergenholtz G (1996). Interaction between perivascular dendritic cells, neuropeptides and endothelial cells in the dental pulp. In: Proceedings of the International Conference on Dentin/Pulp Complex 1995 and the International Meeting on Clinical Topics of Dentin/Pulp Complex. Shimono M, Maeda T, Suda H, Takahashi K, editors. Tokyo: Quintessence Publishing Co., pp. 182-187.
21. Jontell M, Okiji T, Dahlgren U, Bergenholtz G (1998). Immune defense mechanisms of the dental pulp. Crit Rev Oral Biol Med 9:179-200.
22. Kamal AM, Okiji T, Kawashima N, Suda H (1997). Defense responses of dentin/pulp complex to experimentallyinduced caries in rat molars: an immunohistochemical study on kinetics of pulpal la antigen-expressing cells and macrophages. J Endodont 23:115-120.
23. Kimball ES, Persico FJ, Vaught JL (1988). Substance P, substance K, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease. J Immunol 141:3564-3569.
24. Kimberly CL, Byers MR (1988). Inflammation of rat molar pulp and periodontium causes increased cakitonin gene-related peptide and axonal sprouting. Amt Rec 222:289-300.
25. Lindholm D, Heumann R, Meyer M, Thoenen H (1987). Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330:658-659.
26. Lindholm D, Heumann R, Hengerer B, Thoenen H (1988). Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts. J Biol Chem 263:16348-16351.
27. Lotz M, Vaughan JH, Carson DA (1988). Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 241:1218-1221.
28. Maeda T, Sato O, Ivvanaga T, Takano Y (1992). Immunocyto-chemical localization of nerve growth factor receptor (NGFR) in human teeth. Proc Finn Dent Soc 88(Suppl 1)557-562.
29. McGillis JP, Mitsuhashi M, Payan DG (1991). Immunologie properties of substance P. In: Psychoneuroimmunology. Ader A, Felton DL, Cohen N, editors. San Diego: Academic Press, pp. 209-223.
30. Mize RR (1994). Quantitative image analysis for immunocytochemistry and in situ hybridization. J Neitrosd Meth 54:219-237.
31. Naftel JP, Shamssoolari A, Thueson RK (1992). Immunoasssay evidence for a role of nerve growth factor in development of dental innervation. Proc Finn Dent Soc 88(Suppl l):543-549.
32. Nestle FO, Zheng XG, Thompson CB, Turka LA, Nickoloff BJ (1993). Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets (published erratum appears in J Immimol 152:376,1994). J Immwwl 151:6535-6545.
33. Nong YH, Titus RG, Ribeiro JM, Remold HG (1989). Peptides encoded by the calcitonin gene inhibit macrophage function. J Immwwl 143:45-49.
34. Ohshima H, Sato O, Kawahara I, Maeda T, Takano Y (1995). Responses of immunocompetent cells to cavity preparation in rat molars: an immunohistochemical study using OX6-monoclonal antibody. Connect Tissue Res 32:303-311.
35. Okiji T, Kawashima N, Kosaka T, Matsumoto A, Kobayashi C, Suda H (1992). An immunohistochemical study of the distribution of immunocompetent cells, especially macrophages and la antigen-expressing cells of heterogeneous populations, in normal rat molar pulp (published erratum appears in J Dent Res 71:1760,1992). J Dent Res 71:1196-1202.
36. Okiji T, Sakurai K, Kamal AMM, Kosaka T, Kawashima N, Suda H (1995). Structural relationship between nerves and macrophages in experimentally induced periapical inflammation in rat molars (in Japanese). ]pn J Conserv Dent 38:938-946.
37. Okiji T, Jontell M, Belichenko P, Bergenholtz G, Dahlström A (1997a). Perivascular dendritic cells of the human dental pulp. Acta Physiol Scand 159:163-169.
38. Okiji T, Jontell M, Belichenko P, Dahlgren U, Bergenholtz G, Dahlström A (1997b). Structural and functional association between substance P- and calcitonin gene-related peptideimmunoreactive nerves and accessory cells in the rat dental pulp. J Dent Res 76:1818-1824.
39. Olgart L, Kerezoudis NP (1994). Nerve-pulp interactions. Arch Oral Biol 39:475-545.
40. Payan DG, Brewster DR, Goetzl EJ (1983). Specific stimulation of human T lymphocytes by substance P. J Immunol 131:1613-1615.
41. Ramieri G, Anselmetti GC, Baracchi F, Panzica GC, VigliettiPanzica C, Modica R, et al. (1990). The innervation of human teeth and gingival epithelium as revealed by means of an antiserum for protein gene product 9.5 (PGP 9.5). Am J Anat 189:146-154.
42. Reichert F, Levitzky R, Rotshenker S (1996). Interleukin 6 in intact and injured mouse peripheral nerves. Eur J Neurosci 8:530-535.
43. Sakamoto M, Sanjo D (1992). An immunohistochemical study on human dental pulp in different depth of carious lesion (in Japanese). Jpn J Conserv Dent 35:828-835.
44. Steinman RM (1991). The dendritic cell system and its role in immunogenicity. Ann Rev Immunol 9:271-296.
45. Suzuki N, Kawashima N, Yamamoto H, Suda H (1996). The effects of inferior alveolar nerve denervation on pulpal and periapical defense mechanisms in rats. In: Proceedings of the International Conference on Dentin/Pulp Complex 1995 and the International Meeting on Clinical Topics of Dentin/Pulp Complex Complex. Shimono M, Maeda T, Suda H, Takahashi K, editors. Tokyo: Quintessence Publishing Co., pp. 276-277.
46. Thompson RJ, Doran JF, Jackson P, Dhillon AP, Rode J (1983). PGP 9.5-a new marker for vertebrate neurons and neuroendocrine cells. Brain Res 278:224-228.
47. Yoshiba N, Yoshiba K, Nakamura H, Iwaku M, Ozawa H (1996). Immunohistochemical localization of HLA-DR-positive cells in unerupted and erupted normal and carious human teeth. J Dent Res 75:1585-1589.