Localization and Changes in NADPH-Diaphorase Reactivity and Nitric Oxide Synthase Immunoreactivity in Rat Pulp following Tooth Preparation

Journal of Dental Research

Volumn 78, Issue 10, 1999, Pages 1585-1595

  Law, A S ^a   Baumgardner, K R ^b   Meiler, S T ^c   Gebhart, G F ^d  

^a Department of Endodontics ^*  (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANALYSIS OF VARIANCE; ANIMAL; COMPARATIVE STUDY; CONFERENCE PAPER; DENTAL SURGERY; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MACROPHAGE; MALE; MAXILLA; METABOLISM; MOLAR TOOTH; NERVE CELL; PULPITIS; RAT; SPRAGUE DAWLEY RAT; TIME; TOOTH PULP;

ANALYSIS OF VARIANCE; ANIMALS; DENTAL CAVITY PREPARATION; DENTAL PULP; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MAXILLA; MOLAR; NADPH DEHYDROGENASE; NEURONS; NITRIC OXIDE SYNTHASE; PULPITIS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0033278067     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/00220345990780100301     Document Type: Article

References (68)

1. Ahlberg KF (1978). Influence level of noxious heat stimulation on sensory nerve activity in the feline tooth pulp. Acta Physiol Scand 103:71-80.
2. Aimi Y, Fujimura M, Vincent SR, Kimura H (1991). Localization of NADPH-diaphorase-containing neurons in sensory ganglia of the rat. J Comp Neural 306:382-392.
3. Albina JE, Henry WL Jr (1991). Suppression of lymphocyte proliferation through the nitric oxide synthetase pathway. J Surg Res 50:403-109.
4. Ashwal S, Cole DJ, Osborne TN, Pearce WJ (1994). Dual effects of L-NAME during transient focal cerebral ischemia in spontaneously hypertensive rats. Am J Pliysiol 267:H276-H284.
5. Bergenholtz G, Ahlsted S, Lindhe J (1977). Experimental pulpitis in immunized monkeys. Scand] Dent Res 85:396-406.
6. Bergenholtz G, Nagaoka S, Jontell M (1991). Class II antigen presenting cells in experimentally induced pulpitis. Int Endodont J 24:8-14.
7. Blanco CE, Sieck GC, Edgerton VR (1988). Quantitative histochemical determination of succinic dehydrogenase activity in skeletal muscle fibbers. Histocliem J 20:230-243.
8. Bredt DS, Hwang PM, Snyder SH (1990). Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770.
9. Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH (1991). Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7:615-624.
10. Brodin E, Gazelius B, Olgart L, Nilsson G (1981). Tissue concentration and release of substance P-like immunoreactivity in the dental pulp. Ada Physiol Scand 111:141-149.
11. Busse R, Mulsch A (1990). Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEES Lett 275:87-90.
12. Cole M, Bond CP (1972). Recent advances in automatic image analysis using a television system. J Microsc 96:89-96.
13. D'Souza RN, Bachman T, Baumgardner KR, Butler WT, Litz M (1995). Characterization of cellular responses involved in reparative dentinogenesis in rat molars. J Dent Res 74:702-709.
14. Dawson TW, Bredt DS, Fotuhi M, Hwang PM, Snyder SH (1991). Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Nntl Acad Sci USA 88:7797-7801.
15. DelBalso AM, Nishimura RS, Setterstrom JA (1976). The effects of thermal and electrical injury on pulpal histamine levels. Oral Surg 41:110-113.
16. Diaz-Araya CM, Provis JM, Billson FA (1993). NADPH-diaphorase histochemistry reveals cone distributions in adult human retinae. Aust NZ J Ophthalmol 21:171-179.
17. Fischer A, Mundell P, Mayer B, Preissler U, Philippin B, Kummer W (1993). Nitric oxide synthase in guinea pig lower airway innervation. Neurosci Lett 149:157-160.
18. Gabbott PLA, Bacon SJ (1993). Histochemical localization of NADPH dependent diaphorase (nitric oxide synthase) activity in vascular endothelial cells in the rat brain. Neuroscience 57:79-95.
19. Gazelius B, Edwall B, Olgart L, Lundberg JM, Hokfelt T, Fischer JA (1987). Vasodilatory effects and coexistence of calcitonin gene-related peptide (CGRP) and substance P in sensory nerves of cat dental pulp. Acta Physiol Scand 130:33-40.
20. Grozdanovic Z, Baumgarten HG, Bruning G (1992). Histochemistry of NADPH-diaphorase, a marker for neuronal nitric oxide synthase, in the peripheral autonomic nervous system of the mouse. Neuroscience 48:225-235.
21. Grutzner EH, Carry MG, Hargreaves KM (1992). Effect of injury on pulpal levels of immunoreactive substance P and immunoreactive calcitonin gene-related peptide. J Endodont 18:553-577.
22. Hahn CL, Falkler WA Jr, Siegel MA (1989). A study of T and B cells in pulpal pathosis. J Endodont 15:20-26.
23. Hibbs JB Jr, Taintor RR, Vavrin Z, Rachlin EM (1987). Nitric oxide; a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157:87-94.
24. Hirafuji M, Ogura Y (1987). 5-Hydroxytryptamine stimulates the release of prostacyclin but not thromboxane A2 from isolated rat dental pulp. Eur J Pluirmacol 136:433-436.
25. Hirafuji M, Satoh S, Ogura Y (1980). Prostaglandins in rat pulp tissue. J Dent Res 59:1535-1540.
26. Hirafuji M, Terashima K, Satoh S, Ogura Y (1982). Stimulation of prostaglandin E2 biosynthesis in rat dental pulp expiants in vitro by 5-hydroxytryptamine. Arch Oral Biol 27:961-964.
27. Hope BT, Michael GJ, Knigge KM, Vincent SR (1991). Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci USA 88:2811-2814.
28. ladecola C, Beitz AJ, Renno W, Xu X, Mayer B, Zhang F (1993). Nitric oxide synthase-containing neural processes on large cerebral arteries and cerebral microvessels. Brain Res 606:148-155.
29. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G (1987). Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84:9265-9269.
30. Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD (1992). Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 267:14519-14522.
31. Kerezoudis NP, Olgart L, Edwall L (1993a). Differential effects of nitric oxide synthesis inhibition on basal blood flow and antidromic vasodilation in rat oral tissues. Eur J Pharnmcol 241:209-219.
32. Kerezoudis NP, Olgart L, Fried K (1993b). Localization of NADPH-diaphorase activity in the dental pulp periodonrium and alveolar bone of the rat. Histochemistry 100:319-322.
33. Khayat BG, Byers MR, Taylor PE, Mecifi K, Kimberly CL (1988). Responses of nerve fibers to pulpal inflammation and periapical lesions in rat molars demonstrated by calcitonin generelated peptide immunocytochemistry. J Endodont 14:577-587.
34. Kilbourn RG, Belloni P (1990). Endothelial cell production of nitrogen oxides in response to Interferon in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Natl Cane Inst 82:772-776.
35. G-methyl-L-arginine, an inhibitor of nitric oxide synthase. Biochem Biophys Res Commun 172:1132-1138.
36. Kummer W, Fischer A, Mündel P, Mayer B, Hoba B, Philippin B, et al. (1992). Nitric oxide synthase in VIP-containing vasodilator nerve fibres in the guinea-pig. Neuroreport 3:653-655.
37. Lamas S, Marsden PA, Li G-K, Tempst P, Michel T (1992). Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme form. Proc Natl Acad Sci USA 89:6348-6352.
38. Lohinai Z, Balla I, Marczis J, Vass Z, Kovach AG (1995). Evidence for the role of nitric oxide in the circulation of the dental pulp. J Dent Res 74:1501-1506.
39. Lohinai Z, Szekely AD, Benedek P, Csillag A (1997). Nitric oxide synthase containing nerves in the cat and dog dental pulp and gingiva. Neurosci Lett 227:91-94.
40. MacNaul KL, Hutchinson NI (1993). Differential expression of iNOS and cNOS in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions. Biodiem Biophys Res Commun 196:1330-1334.
41. Madison S, Whitsel EA, Suarez-Roca H, Maixner W (1992). Sensitizing effects of leukotriene B4 on intradental primary afferents. Pain 49:99-104.
42. Marietta MA (1989). Nitric oxide: biosynthesis and biological significance. Trends Biochem Sci 14:488-492.
43. McCall TB, Palmer RM, Moncada S (1991). Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone. Eur J Immimol 21:2523-2527.
44. Moncada S, Palmer RMJ, Higgs EA (1991). Nitric oxide: physiology, pathology, and pharmacology. Pliarmacol Rev 43:109-142.
45. Mulligan MS, Hevel JM, Marietta MA, Ward PA (1991). Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci USA 88:6338-6342.
46. Närhi MVO, Hirvonen T (1983). Functional changes in cat pulp nerve activity after thermal and mechanical injury to the pulp. Proc Finn Dent Soc 79:162-167.
47. Nathan CB, Hibbs JB Jr (1991). The role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 3:65-70.
48. Nussler AK, Billiar TR (1993). Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukocyte Biol 54:171-178.
49. Okiji T, Morita I, Sunada I, Murota S (1989). Involvement of arachidonic acid metabolites in increases in vascular permeability in experimental dental pulpal inflammation in the rat. Arch Oral Biol 34:523-528.
50. Olgart L, Edwall L, Gazelius B (1991). Involvement of afferent nerves in pulpal blood-flow reactions in response to clinical and experimental procedures in the cat. Ardi Oral Biol 36:575-581.
51. Oswald RJ, Byers MR (1993). The injury response of pulpal NPYIR sympathetic fibers differs from that of sensory afferent fibers. Neurosci Lett 164:190-194.
52. Panopoulos P, Mejare B, Edwall L (1983). Effects of ammonia and organic acids on the intradental sensory nerve activity. Acta Odontol Scand 41:209-215.
53. Parks DA, Bulkley GB, Granger DN, Hamilton SR, McCord JM (1982). Ischémie injury in the cat small intestine: role of Superoxide radicals. Gastroenterol 82:9-15.
54. Picton W, Clark C (1978). The measurement of histochemicallystained NADP dependent iscitrate dehydrogenase in the subcutaneous glands of hairless hamsters. Hislodian J 10:191-199.
55. Poeggel G, Muller M, Seidel I, Rechardt L, Bernstein HG (1992). Histochemistry of guanylate cyclase, phosphodiesterase, and NADPH-diaphorase (nitric oxide synthase) in rat brain vasculature. J Cardiovasc Plwrmacol 20(12):S76-S79.
56. Pohto P, Antila R (1970). Assay of histamine in dental pulps. Acta Odontol Scand 28:691-699.
57. Pulver WH, Taubman MA, Smith DJ (1977). Immune components in normal and inflamed human dental pulp. Arch Oral Biol 22:103-111.
58. Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S (1990). Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Plumimcol 101:746-752.
59. Sessa WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D'Angelo DD, et al. (1992). Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Cliem 267:15274-15276.
60. Silverman JD, Kruger L (1987). An interpretation of dental innervation based upon the pattern of calcitonin gene-related peptide (CGRP) immuno-reactive thin sensory axons. Somatosens Res 5:157-175.
61. Stuehr DJ, Cho HJ, Kwon NS, Weise MF, Nathan CF (1991). Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci USA 88:7773-7777.
62. Takahashi K (1990). Changes in pulpal vasculature during inflammation. J Endodont 16:92-97.
63. Uddman R, Björlin G, MöUer B, Sundler F (1980). Occurrence of VIP nerves in mammalian dental pulps. Ada Odontol Scand 38:325-328.
64. Wakisaka S, Ichikawa H, Nishimoto T, Matsuo S, Yamamoto K, Nakata T, et al. (1984). Substance P-like immunoreactivity in the pulp-dentine zone of human molar teeth demonstrated by indirect immunofluorescence. Arch Oral Biol 29:73-75.
65. Ward SM, Xue C, Shuttleworth CW, Bredt DS, Snyder SH, Sanders KM (1992). NADPH diaphorase and nitric oxide synthase colocalization in enteric neurons of canina proximal colon. Am J Physiol 263:G277-G284.
66. Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Wachter H (1990). Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J Exp Med 172:1599-1607.
67. Wilcox JN, Subramanian RR, Sundell CL, Tracey WR, Pollock JS, Harrison DG, et al. (1997). Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arteriosd Tliromb Vase Biol 17:2479-2488.
68. Willis RA, Nussler AK, Fries KM, GeUer DA, Phipps RP (1994). Induction of nitric oxide synthase in subsets of murine pulmonary fibroblasts: effect on interleukin-6 production. Clin Immimol Imtmmopathol 71:231-239.