Clinical Experience with a Human Skin Equivalent for the Treatment of Venous Leg Ulcers: Process and Outcomes

Wounds

Volumn 11, Issue 6, 1999, Pages 137-144

  Kirsner, Robert ^a   Falanga, Vincent ^b,c   Fivenson, David ^d   Thibodeaux, Kerry ^e   Cavorsi, Joseph ^f   De La Pava, Daniel ^g   Brem, Harold ^h   Golomb, Cynthia A ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b ROGER WILLIAMS MEDICAL CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HENRY FORD HOSPITAL   (United States)

^e TOTAL   (France)

^f Boswell Delwebb ^*  (United States)

^g Boswell Delwebb   (United States)

^h MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033273839     PISSN: 10447946     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Phillips T, Stanton B, Provan A, Lew R. A study of the impact of leg ulcers on quality of life: Financial, social, and psychologic implications. J Am Acad Dermatol 1994;31:49-53.
2. Phillips TJ, Dover JS. Leg ulcers. J Am Acad Dermatol 1991;25:965-87.
3. Olin JW, Beusterien KM, Childs MB, et al. Medical costs of treating venous stasis ulcers: Evidence from a retrospective cohort study. Vasc Med 1999;4:1-7.
4. Falanga V. Care of venous leg ulcers. Ost Wound Mgmt 1999;45:33S-43S.
5. Trent JF, Kirsner RS. Tissue engineered skin: Apligraf, a bi-layered living skin equivalent. Int J Clin Pract 1998;52:408-13.
6. Apligraf® (The human skin equivalent) prescribing information. In: Physicians' Desk Reference, 53rd Edition. Montvale, NJ: Medical Economics, 1998:1992-5.
7. Falanga V, Margolis D, Alvarez O, et al. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Arch Dermatol 1998;134:293-300.
8. Falanga V, Sabolinski M. A bilayered living skin construct (Apligraf®) accelerates complete closure of hard-to-heal venous ulcers. Wound Rep Reg 1999;7:201-7.
9. Margolis DJ, Gross EA, Wood CR, et al. Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing. J Am Acad Dermatol 1993;28:418-21.
10. Tallman P, Muscare E, Carson P, et al. Initial rate of healing predicts complete healing of venous ulcers. Arch Dermatol 1997;133:1231-4.
11. Kantor J, Margolis DJ. Efficacy and prognostic value of simple wound measurements. Arch Dermatol 1998;134:1571-4.
12. Masuda EM, Kistner RL. Long-term results of venous valve reconstruction: A four-to twenty-one-year follow-up. J Vasc Surg 1994;19:391-403.
13. Falanga V. How to use Apligraf to treat venous ulcers. Skin & Aging 1999;7(2):30-6.
14. Kirsner RS, Falanga V, Eaglstein WH. The biology of skin grafts. Skin grafts as pharmacologic agents. Arch Dermatol 1993;129:481-3.
15. Falanga V, Villa K, Schonfeld W, et al. A new cost effective therapy for the treatment of hard to heal venous leg ulcers. Wound Rep Reg 1998;6:A244.