A survey of the recent patent literature on the delivery of genes and oligonucleotides

Journal of Drug Targeting

Volumn 7, Issue 1, 1999, Pages 1-10

  Mrsny, Randall J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE; POLYNUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE;

EDITORIAL; GENE ACTIVITY; GENE EXPRESSION SYSTEM; GENE FUNCTION; GENE INACTIVATION; GENE TARGETING; GENE TECHNOLOGY; GENETIC MANIPULATION; PATENT; PRIORITY JOURNAL; SUICIDE GENE; DRUG DELIVERY SYSTEM; GENE THERAPY; GENE VECTOR; HUMAN; METHODOLOGY; UNITED STATES; VIRUS;

DRUG DELIVERY SYSTEMS; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; PATENTS; UNITED STATES; VIRUSES;

EID: 0033256993     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869909085488     Document Type: Editorial

References (10)

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2. Bennet, R.M. (1993) Is nature offended? The uptake of DNA and oligonucleotides by eukaryotic cells. Antisense Res. Develop., 3, 235-241.
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5. Huang, L. and Li, S. (1997) Liposomal gene delivery: A complex package. Nature Biotechnology, 15, 620-621.
6. Hughes, J.A., Aronsohn, A.I., Avrutskaya, A.V. and Juliano, R.L. (1996) Evaluation of adjuvants that enhance the effectiveness of antisense oligodeoxynucleotides. Pharm. Res., 13, 404-410.
7. Mahato, R.I., Takakura, Y. and Hashida, M. (1997a) Development of targeted delivery systems for nucleic acid drugs. J. Drug Targeting, 4, 337-357.
8. Mahato, R.I., Rolland, A. and Tomlinson, E. (1997b) Cationic lipid-based gene delivery systems: pharmaceutical perspectives. Pharm. Res., 14, 853-859.
9. Scanlon, K.J., Ohta, Y., Ishida, H., Kijima, H., Ohkawa, T., Kaminski, A., Tsai, J., Horng, G. and Kashani-Sabet, M. (1995) Oligonucleotide-mediated modulation of mammalian gene expression. FASEB J., 9, 1288-1296.
10. Tonkinson, J.L. and Stein, C.A. (1994) Patterns of intracellular compartmentalization, trafficking and acidification of 5′-fluorescein labeled phosphodiester and phosphorothioate oligodeoxynucleotides in HL60 cells. Nucleic Acids Res., 22, 4268-4275.