Microglia and neuritic plaques in familial Alzheimer's disease induced by a new mutation of presenilin-1 gene. An Ultrastructural study

Folia Neuropathologica

Volumn 37, Issue 4, 1999, Pages 243-246

  Lewandowska, Eliza ^a   Bertrand, Ewa ^a   Kulczycki, Jerzy ^a   Lipczyńska Łojkowska, Wanda ^a   Lechowicz, Waldemar ^a   Stankiewicz, Jadwiga ^a  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

Author keywords

Alzheimer's disease; Microglia; Neuritic plaques

Indexed keywords

MEMBRANE PROTEIN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

ADULT; ALZHEIMER DISEASE; ARTICLE; BRAIN; CASE REPORT; ELECTRON MICROSCOPY; FEMALE; GENETICS; HUMAN; MICROGLIA; MIDDLE AGED; PATHOLOGY; POINT MUTATION; SENILE PLAQUE; ULTRASTRUCTURE;

ADULT; ALZHEIMER DISEASE; BRAIN; FEMALE; HUMANS; MEMBRANE PROTEINS; MICROGLIA; MICROSCOPY, ELECTRON; MIDDLE AGED; POINT MUTATION; PRESENILIN-1; SENILE PLAQUES;

EID: 0033256551     PISSN: 00283894     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Fra̧ckowiak J, Wiśniewski HM, Wȩgiel J, Merz GS, Wang KC: Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce β-amyloid fibrils. Acta Neuropathol (Berl), 1992, 84, 225-233.
2. Mandybur TI, Chuirazzi BA: Astrocytes and the plaques of Alzheimer's disease. Neurology, 1990, 40, 635-639.
3. McGeer PL, Akiyama H, Kawamata T, Walker DG, Ishii T: Immunohistochemical localization of beta-amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy. J Neurosci Res, 1992, 31, 422-428.
4. Perimutter LS, Baron E, Chang Chui H: Morphological association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett, 1990, 119, 32-36.
5. Roher A, Gray EG, Paula-Barbosa M: Alzheimers's disease: coated vesicles, coated pits and the amyloid-related cell. ProcR Soc Lond, 1988, 232, 367-373.
6. Tagliavini F, Giaccone G, Frangione B, Bugiani O: Preamyloid deposites in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals. Neurosci Lett, 1988, 93, 191-196.
7. Wȩgiel J, Wiśniewski HM: The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol (Berl), 1990, 81, 116-124.
8. Wiśniewski HM, Terry RD: Reexamination of the pathogenesis of the senile plaque. Progress in Neuropathology. Vol II, Zimmerman HM (ed), Grune & Stratton, Inc 1973.
9. Wiśniewski HM, Dowiat WK, Buxbaum JD, Khorkova O, Efthimiopoulos S, Kulczycki J, Łojkowska W, Wȩgiel J, Wiśniewski HM, Frangione B: A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years. Neuroreport, 1998, 9, 217-221.
10. Wiśniewski HM, Wȩgiel J, Wang KC, Kujawa M, Lach B: Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can J Neurosci, 1989, 16, 535-541.