High serum concentrations of sialyl Tn antigen in carcinomas of the biliary tract and pancreas

Journal of Hepato-Biliary-Pancreatic Surgery

Volumn 6, Issue 4, 1999, Pages 391-395

  Nanashima, Atsushi ^a   Yamaguchi, Hiroyuki ^a   Nakagoe, Tohru ^a   Matsuo, Seiji ^a   Sumida, Yorihisa ^a   Tsuji, Takashi ^a   Sawai, Terumitsu ^a   Yamaguchi, Eiichirou ^a   Yasutake, Toru ^a   Ayabe, Hiroyoshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Biliary tract; Pancreas; STn antigen

Indexed keywords

TUMOR ANTIGEN; TUMOR MARKER;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BILIARY TRACT TUMOR; BLOOD; CHI SQUARE DISTRIBUTION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MICROPHOTOGRAPHY; MIDDLE AGED; PANCREAS TUMOR; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BILIARY TRACT NEOPLASMS; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PHOTOMICROGRAPHY; TUMOR MARKERS, BIOLOGICAL;

EID: 0033252891     PISSN: 09441166     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005340050137     Document Type: Article

References (22)

1. Steinberg WM, Gelfand R, Anderson KK, Glenn J, Kurtzman SH, Sindelar WF, Tosker PP (1986) Comparison of the sensitivity and specificity of the CA19-9 and carcinoembryonic antigen assays in detecting cancer of the pancreas. Gastroenterology 90:343-349
2. Sakamoto K, Haga Y, Yoshimura R, Egami H, Yokoyama Y, Akagi M (1987) Comparative effectiveness of the tumour diagnostics, CA 19-9, CA125 and carcinoembryonic antigen in patients with diseases of the digestive system. Gut 28:323-329
3. Satake K, Chung YS, Umeyama K, Takeuchi T, Kim YS (1989) Diagnostic usefulness and limitation of measuring pancreatic cancer-associated antigen, Span-1, in patients with pancreatic cancer (in Japanese with English Abstract) Gan To Kagaku Ryoho (Jpn J Cancer Chemother) 16:1139-1146
4. Sawabu N, Toya D, Takemori Y, Hattori N, Fukui M (1986) Measurement of a pancreatic cancer-associated antigen (DU-PAN-2) detected by a monoclonal antibody in sera of patients with digestive cancers. Int J Cancer 37:693-696
5. Takemori Y, Sawabu N, Satomura Y, Ohta H, Watanebe H, Okai T, Mai M, Hattori N, Akiyama T, Hashimoto T (1987) Determination of serum DU-PAN-2 by enzyme immunoassay in patients with various digestive cancers (in Japanese with English abstract) Gan to Kagaku Ryoho (Jpn J Cancer Chemother) 14:119-126
6. Filipe MI, Branfoot BM (1974) Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer 34:282-290
7. Dawson PA, Filipe MI (1976) An ultrastructural and histochemical study of the mucus membrane adjacent to and remote from carcinoma of the colon. Cancer 37:2388-2398
8. Matsushita Y, Yamamoto N, Shirahama H, Tanaka S, Yonezawa S, Yamori T, Irimura T, Sato E (1995) Expression of sulfomucins in normal mucosae, colorectal adenocarcinomas, and metastases. Jpn J Cancer Res 86:1060-1067
9. Itzkowitz SH, Yuan M, Montgomery CK, Kjeldsen T, Takahashi HK, Bigbee WL, Kim YS (1989) Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer. Cancer Res 49:197-204
10. Itzkowitz SH, Bloom EJ, Kokal WA, Modin G, Hakomori S, Kim YS (1990) Sialosyl-Tn: a novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer 66:1960-1966
11. Ørntöft TF, Harving N, Langkilde NC (1990) O-Linked mucin-type glycoproteins in normal and malignant colon mucosa: lack of T-antigen expression and accumulation of Tn and sialosyl-Tn antigens in carcinomas. Int J Cancer 45:666-672
12. Lin TR (1992) Evaluation of transitional mucosa of colon with special reference to sialylated antigen and nuclear DNA content. Acta Med Nagasaki 37:229-233
13. Nanashima A, Nakagoe T, Sawai T, Nakamura S, Yamaguchi H, Yasutake T, Kusano H, Ayabe H (1997) Different expressions of sialyl Tn antigen between polypoid and flat type early colorectal cancers. Dis Colon Rectum 40:37-42
14. Motoo Y, Kawakami H, Watanabe H, Satomura Y, Ohta H, Okai T, Makino H, Toya D, Sawabu N (1991) Serum sialyl-Tn antigen level in patients with digestive cancers. Oncology 48:321-326
15. Ching CK, Holmes SW, Holmes GK, Long RG (1994) Blood-group sialyl-Tn antigen is more specific than Tn as a tumor marker in the pancreas. Pancreas 9:698-702
16. Terada T, Nakanuma Y (1996) Expression of mucin carbohydrate antigens (T, Tn and sialyl Tn) and MUC-1 gene product in intraductal papillary-mucinous neoplasm of the pancreas. Am J Clin Pathol 105:613-620
17. Japanese Society of Biliary Surgery (JSBS) (1997) General rules for surgical and pathological studies on cancer of the biliary tract (in Japanese). 4th edn. Kanehara, Tokyo
18. Japan Pancreas Society (1996) Classification of pancreatic carcinoma. First English edn. Kanehara, Tokyo
19. Takahashi I, Maehara Y, Kusumoto T, Yoshida M, Kakeji Y, Kusumoto H, Furusawa M, Sugimachi K (1993) Predictive value of preoperative serum sialyl Tn antigen levels in prognosis of patients with gastric cancer. Cancer 72:1836-1840
20. Ohsio G, Manabe T, Watanabe Y, Endo K, Kudo H, Suzuki T, Tobe T (1990) Comparative studies of DU-PAN-2, carcinoembryonic antigen, and CA19-9 in the serum and bile of patients with pancreatic and biliary tract diseases: evaluation of the influence of obstructive jaundice. Am J Gastroenterol 85:1370-1376
21. Ng WW, Tong KJ, Tam TN, Lee SD (1995) Clinical values of CA19-9, CA125 and CEA in malignant obstructive jaundice (English abstract). Chung Hua I Hsueh Tsa Chih (Taipei) 55:438-446
22. 111In-labeled anti-STn antibody in the management of colorectal cancer. Preliminary and clinical results (in Japanese with English abstract). Nippon Daichou Koumon Byou Gakkai Zasshi (J Jpn Soc Proctol) 51:539-546