Carbohydrate epitopes and mucins expressed by 17 human ovarian carcinoma cell lines

Oncology Research

Volumn 11, Issue 5, 1999, Pages 233-241

  Tamada, Yutaka ^a,b   Iida, Shin Ichiro ^b   Aoki, Daisuke ^a   Nozawa, Shiro ^a   Irimura, Tatsuro ^b  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Carbohydrate epitope; Monoclonal antibody; Mucins; Ovarian carcinoma; Prognosis; Reverse transcription polymerase chain reaction

Indexed keywords

EPITOPE; MESSENGER RNA; MONOCLONAL ANTIBODY; MUCIN; TUMOR PROTEIN;

ADENOCARCINOMA; ARTICLE; CELL CULTURE; COLLOID CARCINOMA; CYSTADENOCARCINOMA; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; OVARY TUMOR; PATHOLOGY;

ADENOCARCINOMA, CLEAR CELL; ADENOCARCINOMA, MUCINOUS; ANTIBODIES, MONOCLONAL; CYSTADENOCARCINOMA, SEROUS; EPITOPES; FEMALE; FLOW CYTOMETRY; HUMANS; MUCINS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0033252299     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Rubin, S. C.; Wong, G. Y. C.; Curtin, J. P.; Barakat, R. R.; Hakes, T. B.; Hoskins, W. J. Platinum-based chemotherapy of high-risk stage I epithelial ovarian cancer following comprehensive surgical staging. Obstet. Gynecol. 82:143-147; 1993.
2. Högberg, T.; Carstensen, J.; Simonsen, E. Treatment results and prognostic factors in a population-based study of epithelial ovarian cancer. Gynecol. Oncol. 48:38-49; 1993.
3. Bertelsen, K. Tumor reduction surgery and long-term survival in advanced ovarian cancer.: A DACOVA study. Gynecol. Oncol. 38: 203-209; 1990.
4. Einhorn, N.; Nilsson, B.; Sjövall, K. Factors influencing survival in carcinoma of the ovary. Study from a well-defined Swedish population. Cancer 55:2019-2025; 1995.
5. Irimura, T.; Matsushita, Y.; Yamori, T.; Hoff, S. D.; Nakamori, S.; Frazier, M. L.; Giacco, G. G.; Cleary, K. R.; Ota, D. M. Ectopic expression of mucins in colorectal cancer metastasis. Semin. Cancer Biol. 2:129-139; 1991.
6. x antigens. Semin. Cancer Biol. 4:319-324; 1993.
7. Brockhausen, I.; Moller, G.; Merz, G.; Adermann, K.; Paulsen, H. Control of mucin synthesis: The peptide portion of synthetic O-glycopeptide substrates influences the activity of O-glycan core 1 UDP galactose:N-acetyl-alpha-galactosaminyl-R beta 3-galactosyl-transferase. Biochemistry 29:10206-10212; 1990.
8. Hanski, C.; Drechsler, K.; Hanisch, F.-G.; Sheehan, J.; Manske, M.; Ogorek, D.; Klussmann, E.; Hanski, M.-L.; Blank, M.; Xiang, P.-X.; McKenzie, I. F. C.; Devine, P. L.; Riecken, E.-O. Altered glycosylation of the MUC1 protein core contributes to the colon carcinoma-associated increase of mucin bound sialyl Lewis X expression. Cancer Res. 53:4082-4088; 1993.
9. X-positive mucins present in colon, colon carcinoma, and sera of patients with colorectal cancer. Cancer Res. 55:928-933; 1995.
10. Zhang, K.; Baeckstrom, D.; Brevinge, H.; Hansson, G. C. Secreted MUC1 mucins lacking their cytoplasmic part and carrying sialyl-Lewis a and X epitopes from a tumor cell line and sera of colon carcinoma patients can inhibit HL-60 leucocyte adhesion to E-selectin-expressing endothelial cells. J. Cell Biochem. 60:538-549; 1996.
11. Baeckstrom, D.; Hansson, G. C.; Nilsson, O.; Johansson, C.; Gendler, S. J.; Lindholm, L. Purification and characterization of a membrane-bound and a secreted mucin-type glycoprotein carrying the carcinoma-associated sialyl-Le a epitope on distinct core proteins. J. Biol. Chem. 266:21537-21547; 1991.
12. Kim, Y. S.; Gum, J. R., Jr.; Brockhausen, I. Mucin glycoproteins in neoplasia. Glycoconjugate J. 13:693-707; 1996.
13. Giuntoli, R. L., II; Rodriguez, G. C.; Whitaker, R. S.; Dodge, R.; Voynow, J. A. Mucin gene expression in ovarian cancers. Cancer Res. 58:5546-5550; 1998.
14. Federici, M. F.; Kudryashov, V.; Saigo, P. E.; Finstad, C. L.; Lloyd, K. O. Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: Serous and mucinous tumors exhibit distinctive patterns of expression. Int. J. Cancer 81:193-198; 1999.
15. Springer, G. F. T and Tn, general carcinoma autoantigens. Science 224:1198-1206; 1984.
16. Livingston, P. O.; Zhang, S.; Lloyd, K. O. Carbohydrate vaccines that induce antibodies against cancer. Cancer Immunol. Immunother. 45:1-9; 1997.
17. Foon, K. A.; Yannelli, J.; Bhattacharya-Chatterjee, M. Colorectal cancer as a model for immunotherapy. Clin. Cancer Res. 5:225-236; 1999.
18. Nozawa, S.; Tsukazaki, K.; Sakayori, M.; Jeng, C.-H.; Iizuka, R. Establishment of a human ovarian clear cell carcinoma cell line (RMG-I) and its single cell cloning. Hum. Cell 1:426-435; 1988.
19. Nozawa, S.; Yajima, M.; Sasaki, H.; Tsukazaki, K.; Aoki, D.; Sakayori, M.; Udagavva, Y.; Kobayashi, T.; Sato, I.; Furusako, S.; Mochizuki, H. A new CA125-like antigen (CA602) recognized by two monoclonal antibodies against a newly established ovarian clear cell carcinoma cell line (RMG-II). Jpn. J. Cancer Res. 82: 854-861; 1991.
20. Sasa, H.; Kikuchi, Y.; Hisano, A.; Ishii, K.; Nagata, I.; Kawai, T.; Aida, S.; Sugita, M.; Sugishita, T.; Tenjin, Y. Cytokinetic effects of cisplatin on cisplatin-resistant ovarian cancer cell lines [in Japanese]. Hum. Cell 5:384-391; 1992.
21. Ishiwata, I.; Ishiwata, C.; Soma, M.; Ishikawa, H. Establishment of HUOCA-II, a human ovarian clear cell adenocarcinoma cell line, and its angiogenic activity. J. Natl. Cancer Inst. 78:667-673; 1987.
22. Lau, D. H. M.; Lewis, A. D.; Ehsan, M. N.; Sikic, B. I. Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin. Cancer Res. 51:5181-5187; 1991.
23. Sakayori, M.; Nozawa, S.; Udagawa, Y.; Chin, K.; Lee, S.-G.; Sakuma, T.; lizuka, R.; Wada, Y.; Yoshida, S.; Takeda, Y. Biological properties of two newly established cell lines (RMUG-S, RMUG-L) from a human ovarian mucinous cystadenocarcinoma [in Japanese]. Hum. Cell 3:52-56; 1990.
24. Kidera, Y.; Yoshimura, T.; Ohkuma, Y.; Iwasaka, T.; Sugimori, H. Establishment and characterization of a cell line derived from mucinous cystadenocarcinoma of human ovary [in Japanese). Acta Obstet. Gynaecol. Jpn. 37:1820-1824; 1985.
25. Yamada, T.; Ueda, M.; Otsuki, Y.; Ueki, M.; Sugimoto, O. Establishment and characterization of a cell line (OMC-3) originating from a human mucinous cystadenocarcinoma of the ovary. Gynecol. Oncol. 40:118-128; 1991.
26. Horowitz, A. T.; Treves, A. J.; Voss, R.; Okon, E.; Fuks, Z.; Davidson, L.; Biran, S. A new human ovarian carcinoma cell line: Establishment and analysis of tumor-associated markers. Oncology 42:332-337; 1985.
27. Udagawa, Y.; Nozawa, S.; Chin, K.; Sakayori, M.; Mikami, M.; Ohta, K.; Tsukazaki, K.; Kiguchi, K.; lizuka, R. Establishment and characterization of a human chorionic gonadotropin (hCG)-producing cell line (RTSG) from an ovarian epithelial cancer [in Japanese]. Hum. Cell 3:70-75; 1990.
28. Kikuchi, Y.; Miyauchi, M.; Kizawa, I.; Oomori, K.; Kato, K. Establishment of a cisplatin-resistant human ovarian cancer cell line. J. Natl. Cancer. Inst. 77:1181-1185; 1986.
29. Ishiwata, I.; Ishiwata, C.; Soma, M.; Nozawa, S.; Ishikawa, H. Characterization of newly established human ovarian carcinoma cell line-special reference to the effects of cis-platinum on cellular proliferation and release of CA125. Gynecol. Oncol. 26:340-354; 1987.
30. Ishiwata, I.; Ishiwata, C.; Kobayashi, N.; Ishikawa, H. Characterization of newly established cell line HUOA from a human ovarian serous cystadenocarcinoma [in Japanese]. Acta Obstet. Gynaecol. Jpn. 39:831-836; 1987.
31. Gendler, S. J.; Burchell, J. M.; Duhing, T.; Lamport, D.; White, R.; Parker, M.; Talor-Papadimitriou, J. Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium. Proc. Natl. Acad. Sci. USA 84:6060-6064; 1987.
32. Lan, M. S.; Batra, S. K.; Qi, W.; Metzgard, R. S.; Hollingsworth, M. A. Cloning and sequencing of a human pancreatic tumor mucin cDNA. J. Biol. Chem. 265:15294-15299; 1990.
33. Gum, J. R., Jr.; Hicks, J. W.; Toribara, N. W.; Kim, Y. S.; Siddiki, B. Molecular cloning of human intestinal mucin (MUC2) cDNA: Identification of the amino terminal and overall sequence similarity to pre-pro-von Willebrand factor. J. Biol. Chem. 269:2440-2446; 1994.
34. Gum, J. R., Jr.; Ho, J. J. L.; Pratt, W. S.; Hicks, J. W.; Hill, A. S.; Vinall, L. E.; Roberton, A. M.; Swallow, D. M.; Kim, Y. S. MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region. J. Biol. Chem. 272:26678-26686; 1997.
35. Guyonnet-Duperat, V.; Audie, J. P.; Debailleul, V.; Laine, A.; Buisine, M. P.; Galiegue-Zouitina, S.; Pigny, P.; Degand, P.; Aubert, J. P.; Porchet, N. Characterization of the human mucin gene MUC5AC: A consensus cysteine-rich domain for 11P15 mucin gene? Biochem. J. 305:211-219; 1995.
36. Desseyn, J. L.; Guyonnet-Duperat, V.; Porchet, N.; Aubert, J. P.; Laine, A. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a superrepeat. Structural evidence for a 11p15.5 gene family. J. Biol. Chem. 272:3168-3178; 1997.
37. Toribara, N. W.; Roberton, A. M.; Ho, S. B.; Kuo, W. L.; Gum, E.; Hicks, J. W.; Gum, J. R., Jr.; Byrd, J. C.; Siddiki, B.; Kim, Y. S. Human gastric mucin. Identification of a unique species by expression cloning. J. Biol. Chem. 268:5879-5885; 1983.
38. Nakajima-Iijima, S.; Hamada, H.; Reddy, P.; Kakunaga, T. Molecular structure of the human cytoplasmic beta-actin gene: Interspecies homology of sequences in the introns. Proc. Natl. Acad. Sci. USA 82:6133-6137; 1985.
39. Iida, S.; Tsuiji, H.; Nemoto, Y.; Sano, Y.; Reddish, M. A.; Irimura, T. Expression of mucin genes and carbohydrate epitopes in nineteen human colon carcinoma cell lines. Oncol. Res. 10:407-414; 1998.
40. Mochizuki, H.; Nagoya, K.; Yamauchi, T.; Takao, Y.; Masuko, H.; Sato, H.; Sasaki, H.; Itoh, K.; Tsuzuki, K.; Udagawa, Y.; Kobayashi, T.; Nozawa, S. Specificity of a tumor marker (CA54/61) and its individual epitopes recognized by monoclonal antibodies, MA54 and MA61, in human tumor patients. J. Clin. Lab. Anal. 6: 225-231; 1992.
41. Kjeldsen, T.; Clausen, H.; Hirohashi, S.; Ogawa, T.; Iijima, H.; Hakomori, S. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2-6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res. 48:2214-2220; 1988.
42. Magnani, J. L.; Nilsson, B.; Brockhaus, M.; Zopf, D.; Steplewski, Z.; Koprowski, H.; Ginsburg, V. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J. Biol. Chem. 257: 14365-14369; 1982.
43. Yamori, T.; Ota, D. M.; Cleary, K. R.; Hoffs, S.; Hager, L. G.; Irimura, T. Monoclonal antibody against human colonic sulfomucin: Immunohistochemical detection of its binding sites in colonic mucosa, colorectal primary carcinoma and metastasis. Cancer Res. 49:887-894; 1989.
44. Narimatsu, H.; Iwasaki, H.; Nishihara, S.; Kimura, H.; Kudo, T.; Yamauchi, Y.; Hirohashi, S. Genetic evidence for the Lewis enzyme, which synthesizes type-1 Lewis antigens in colon tissue, and intracellular localization of the enzyme. Cancer Res. 56:330-338; 1996.
45. Fukushi, Y.; Nudelman, E.; Levery, S. B.; Hakomori, S.; Rauvala, H. Novel fucolipids accumulating in human adenocarcinoma. III. A hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside (VI3NeuAcV3III3Fuc2nLc6). J. Biol. Chem. 259:10511-10517; 1984.
46. Hanai, N.; Shitara, K.; Yoshida, H. Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung. Cancer Res. 46:4438-4443; 1986.
47. Burchell, J.; Durbin, H.; Taylor-Papadimitriou, J. Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells. J. Immunol. 31:508-513; 1983.
48. Yamamoto, M.; Bhavanandan, V. P.; Nakamori, S.; Irimura, T. A novel monoclonal antibody specific for sialylated MUC1 mucin. Jpn. J. Cancer Res. 7:488-496; 1996.
49. O'Brien, T. J.; Raymond, L. M.; Bannon, G. A.; Ford, D. H.; Hardardottir, H.; Miller, F. C.; Quirk, J. G., Jr. New monoclonal antibodies identify the glycoprotein carrying the CA125 epitope. Am. J. Obstet. Gynecol. 165:1857-1864; 1991.
50. Montag, A. G.; Jenison, E. L.; Griffiths, C. T.; Welch, W. R.; Lavin, P. T.; Knapp, R. C. Ovarian clear cell carcinoma: A clinicopathologic analysis of 44 cases. Int. J. Gynecol. Pathol. 8:85-96; 1989.
51. Russell, P. Surface epithelial-stromal tumors of the ovary. In: Kurman, R. J., eds. Blaustein's pathology of the female genital tract, 4th ed. New York: Springer-Verlag; 1994:705-782.
52. Fenoglio, C. M.; Ferenczy, A.; Richart, R. M. Mucinous tumors of the ovary: Ultrastructural studies of mucinous cystadenomas with histogenetic considerations. Cancer 36:1709-1722; 1975.
53. Gipson, I. K.; Ho, S. B.; Spurr-Michaud, S. J.; Tisdale, A. S.; Zhan, Q.; Torlakovic, E.; Pudney, J.; Anderson, D. J.; Toribara, N. W.; Hill, J. A., III. Mucin genes expressed by human female reproductive tract epithelia. Biol. Reprod. 56:999-1011; 1997.
54. Hanski, C.; Hofmeier, M.; Schmitt-Graff, A.; Riede, E.; Hanski, M. L.; Borchard, F.; Sieber, E.; Niedobitek, F.; Foss, H. D.; Stein, H.; Riecken, E. O. Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary. J. Pathol. 182:385-391; 1997.
55. Dong, Y.; Walsh, M. D.; Cummings, M. C.; Wright, R. G.; Khoo, S. K.; Parsons, P. G.; McGuckin, M. A. Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours. J. Pathol. 183: 311-317; 1997.
56. Nakamori, S.; Ota, D. M.; Cleary, K. R.; Shirotani, K.; Irimura, T. MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology 106:353-361; 1994.
57. Fujita, K.; Denda, K.; Yamamoto, M.; Matsumoto, T.; Fujime, M.; Irimura, T. Expression of MUC1 mucins inversely correlated with postsurgical survival of renal cell carcinoma patients. Br. J. Cancer 80:301-308; 1999.
58. Burdick, M. D.; Harris, A.; Reid, C. J.; Iwamura, T.; Hollings-worth, M. A. Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines. J. Biol. Chem. 272:24198-24202; 1997.
59. X expression level in human pre-B lymphocytic leukemia cell line KM3 treated with phorbolester. J. Biol. Chem. 273:26779-26789; 1998.