Individual or combined effects of enalapril and verapamil on chronic cyclosporine nephrotoxicity in rats

Journal of Korean Medical Science

Volumn 14, Issue 6, 1999, Pages 653-658

  Lee, Sang Koo ^a,b   Park, Joo Yeol ^b   Yu, Eun Sil ^b   Yang, Won Seok ^a   Kim, Soon Bae ^a   Park, Su Kil ^a   Park, Jung Sik ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b University of Ulsan   (South Korea)

Author keywords

Cyclosporine; Enalapril; Gene expression; Verapamil

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENDOTHELIN 1; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA; OSTEOPONTIN; PROCOLLAGEN; SIALOGLYCOPROTEIN; SPP1 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA; VERAPAMIL;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG COMBINATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; KIDNEY CORTEX; MALE; METABOLISM; NEPHRITIS; RAT; WISTAR RAT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CYCLOSPORINE; DRUG THERAPY, COMBINATION; ENALAPRIL; ENDOTHELIN-1; GENE EXPRESSION REGULATION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY CORTEX; MALE; NEPHRITIS; OSTEOPONTIN; PROCOLLAGEN; RATS; RATS, WISTAR; RNA, MESSENGER; SIALOGLYCOPROTEINS; TRANSFORMING GROWTH FACTOR BETA; VERAPAMIL;

EID: 0033251859     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.1999.14.6.653     Document Type: Article

References (21)

1. Bennet WM, DeMattos A, Meyer MM, Andoh T, Barry JM. Chronic cyclosporine nephropathy: the Achilles' heel of immunosuppressive therapy. Kidney Int 1996; 50: 1089-100.
2. Burdmann EA, Andoh TF, Nast CC, Evan A, Connors BA, Coffman TM, Lindsley J, Bennett WM. Prevention of experimental cyclosporine-induced interstitial fibrosis by losartan and enalapril. Am J Physiol 1995; 269: F491-9.
3. Shihab FS, Andoh TF, Tanner AM, Noble NA, Border WA, Franceschini N, Bennett WM. Role of transforming growth factor-beta 1 in experimental chronic cyclosporine nephropathy. Kidney Int 1996; 49: 1141-51.
4. Pichler RH, Franceschini N, Young BA, Hugo C, Andoh TF, Burdmann EA, Shankland SI, Alpers CE, Bennett WM, Couser WG, Johnson RJ. Pathogenesis of cyclosporine nephropathy: roles of angiotension II and osteopontin. J Am Soc Nephrol 1995; 6: 1186-96.
5. Nast CC, Adler SG, Artishevsky A, Kresser CT, Ahmed K, Anderson PS. Cyclosporine induces elevated procollagen α1 (I) mRNA levels in the rat renal cortex. Kidney Int 1991; 39: 631-8.
6. Shehata M, Cope GH, Johnson TS, Raftery AT, El Nahas AM. Cyclosporine enhances the expression of TGF-β in the juxtaglomerular cells of the rat kidney. Kidney Int 1995; 48: 1487-96.
7. Lee SK, Goyal M, Miguel MD, Thomas P, Wharram B, Dysko R, Phan S, Killen PD, Wiggins RC. Renal biopsy collagen 1 mRNA predicts scarring in rabbit anti-GBM disease: comparison with conventional measures. Kidney Int 1997; 52: 1000-15.
8. Singh K, Mukherjee AB, De Vouge MW, Mukherjee BB. Differential processing of osteopontin transcripts in rat kidney and osteoblast derived cell lines. J Biol Chem 1992; 267: 23847-51.
9. Sakurai T, Yanagisawa M, Inoue A, Ryan US, Kimura S, Mitsui Y, Goto K, Masaki T. cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. Biochem Biophys Res Commun 1991; 175: 44-7.
10. Bernard MP, Chu ML, Meyer JC, Ramirez F, Eikenberry EF, Prockop DL. Nucleotide sequences of complimentary deoxyribonucleic acids for the pro-a1 chain of human type 1 procollagen: Statistical evaluation of structures that are conserved during evolution. Biochemistry 1983; 22: 5213-23.
11. Tso JY, Sun XH, Kao TH, Reece KS, Wu R. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res 1985; 13: 2485-502.
12. Wuthrich RP. The complex role of osteopontin in renal disease. Nephrol Dial Transplant 1998; 13: 2448-50.
13. Narita I, Nakayama H, Goto S, Takeda T, Sakatsume M, Saito A, Nakagawa Y, Arakawa M. Identification of genes specially expressed in chronic and progressive glomerulosclerosis. Kidney Int 1997; 63(suppl): S215-7.
14. Giachelli CM, Pichler R, Lombardi D, Denhardt DT, Alpers CE, Schwartz SM, Johnson RJ. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis. Kidney Int 1994; 45: 515-24.
15. Hwang SM, Wilson PD, Laskin JD, Denhardt DT. Age and development-related changes in osteopontin and nitric oxide synthase mRNA levels in human kidney proximal tubule epithelial cells: contrasting responses to hypoxia and reoxygenation. J Cell Physiol 1994; 160: 61-8.
16. Malyankar UM, Almeida M, Johnson RJ, Pichler RH, Giachelli CM. Osteopontin regulation in cultured rat renal epithelial cells. Kidney Int 1997; 51: 1766-73.
17. Shihab FS, Bennett WM, Tanner AM, Andoh TF. Angiotensin II blockade decreases TGF-β1 and matrix proteins in cyclosporine nephropathy. Kidney Int 1997; 52: 660-73.
18. Sahai A, Mei C, Anderson PW, Tannen RL. Chronic hypoxia stimulates the expression of extracellular matrix proteins and TGF-β in cultured mesangial cells. J Am Soc Nephrol 1995; 6: 910.
19. Elzinga LW, Rosen S, Bennett WM. Dissociation of glomerular filtration rate from tubulointerstitial fibrosis in experimental chronic cyclosporine nephropathy: role of sodium intake. J Am Soc Nephrol 1993; 4: 214-21.
20. Abassi ZA, Pieruzzi F, Nakhoul F, Keiser HR. Effects of cyclosporine A on the synthesis, excretion, and metabolism of endothelin in the rat. Hypertension 1996; 27: 1140-8.
21. Takeda Y, Miyamori I, Yoneda T, Takeda R. Increased concentration of endothelin messenger RNA in the mesenteric arteries of cyclosporine-induced hypertensive rats. Am J Hypertens 1993; 6: 427-30.