Frequency and prognostic value of epithelioid granuloma in inflammatory bowel disease;Frequence et valeur pronostique du granulome epithelioide au cours des maladies inflammatoires chroniques de l'intestin

Gastroenterologie Clinique et Biologique

Volumn 23, Issue 12, 1999, Pages 1376-1387

  Heresbach, Denis ^a   Heresbach Le, Nathalie ^a,b   Ramée, Marie Paule ^a   Sémana, Gilbert ^a   Gosselin, Michel ^a   Bretagne, Jean François ^a  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^b Cabinet Med d'Anat/Cytol Pathol   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CROHN DISEASE; ENTERITIS; EPITHELIOID CELL; GRANULOMA; HUMAN; MUCOSA INFLAMMATION; PATHOGENESIS; PROGNOSIS; REVIEW; INTESTINE MUCOSA; PATHOLOGY;

CROHN DISEASE; GRANULOMA; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; PROGNOSIS;

EID: 0033251429     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (129)

1. Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol 1989;24:2-6.
2. Lennard-Jones JE, Lockhart-Mummery HE, Morson BC. Clinical and pathological differentiation of Crohn's disease and proctocolitis. Gastroenterology 1968;54:1162-9.
3. Bernades P, Hecketsweiler P, Benozio M, Descos L, Geffroy Y, Hemet J, et al. Proposition d'un système de critères pour le diagnostic des entérocolites inflammatoires cryptogénétiques (maladie de Crohn et rectocolite hémorragique). Gastroenterol Clin Biol 1978;2:1047-54.
4. Gower-Rousseau C, Salomez JL, Dupas JL, Marti R, Nuttens MC, Votte A, et al. Incidence of inflammatory bowel disease in northern France (1988-1990). Gut 1994;35:1433-8.
5. Notteghem B, Salomez JL, Gower-Rousseau C, Marti R, Lemahieu M, Nuttens MC, et al. Que deviennent les colites aiguës inclassées ? Résultats d'une étude de cohorte de 104 malades dans la région Nord-Pas-de-Calais. Gastroenterol Clin Biol 1993;17: 811-5.
6. Le Berre N, Heresbach D, Kerbaol M, Caulet S, Bretagne JF, Chaperon J, et al. Histological discrimination of idiopathic inflammatory bowel disease from other types of colitis. J Clin Pathol 1995;48:749-53.
7. Seldenrijk CA, Morson BC, Meuwissen SGM, Schipper NW, Lindeman J, Meijer CJLM. Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease : diagnostic implications. Gut 1991;32:1514-20.
8. Surawicz CM, Haggitt RC, Husseman M, McFarland LV. Mucosal biopsy diagnosis of colitis : acute self-limited colitis and idiopathic inflammatory bowel disease. Gastroenterology 1994; 107:755-63.
9. Theodossi A, Spiegelhalter DJ, Jass J, Firth J, Dixon M, Leader M, et al. Observer variation and discriminatory value of biopsy features in inflammatory bowel disease. Gut 1994;35:961-8.
10. Hadfield G. The primary histological lesion of regional ileitis. Lancet 1939;2:773-5.
11. Cortot A, Gower-Rousseau C, Marti R, Colombel JF. Groupes homogènes de malades au cours de la maladie de Crohn : réalité ou fantasme ? Gastroenterol Clin Biol 1998;22:591-3.
12. Brignola C, Iannone P, Belloli C, De Simone G, Bassein L, Gionchetti P, et al. Prediction of relapse in patients with Crohn's disease in remission : a simplified index using laboratory tests, enhanced by clinical characteristics. Eur J Gastroenterol Hepatol 1994;6:955-61.
13. Greenstein AJ, Lachman P, Sachar DB, Springhorn J, Heimann T, Janowitz HD, et al. Perforating and non-perforating indications for repeated operations in Crohn's disease : evidence for two clinical forms. Gut 1988;29:588-92.
14. Hamon JF, Carbonnel F, Beaugerie L, Sezeur A, Gallot D, Malafosse M, et al. Comparaison de l'évolution à long terme des maladies de Crohn perforantes et non perforantes. Gastroenterol Clin Biol 1998;22:601-6.
15. Lautenbach E, Berlin JA, Lichtenstein GR. Risk factors for early postoperative recurrence of Crohn's disease. Gastroenterology 1998;115:259-67.
16. Polito JM, Childs B, Mellits ED, Tokayer AZ, Harris ML, Bayless TM. Crohn's disease : influence of age at diagnosis on site and clinical type of disease. Gastroenterology 1996;111:580-6.
17. Carbonnel F, Macaigne G, Beaugerie L, Gendre JP, Cosnes J. Crohn's disease severity in familial and sporadic cases. Gut 1999;44:91-5.
18. Rutgeerts P, Geboes K, Vantrappen G, Kerremans R, Coenegrachts JL, Coremans G. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut 1984;25:665-72.
19. Sahmoud T, Hoctin-Boes G, Modigliani R, Bitoun A, Colombel JF, Soulé JC, et al. on behalf of the GETAID group. Identifying patients with a high risk of relapse in quiescent Crohn's disease. Gut 1995;37:811-8.
20. Sachar DB, Andrews HA, Farmer RG, Pallone F, Pena AS, Prantera C, et al. Proposed classification of patient subgroups in Crohn's disease. Gastroenterol Int 1992;5:141-54.
21. Sachar DB, Wolfson DM, Greenstein AJ, Goldberg J, Styczynski R, Janowitz HD. Risk factors for postoperative recurrence of Crohn's disease. Gastroenterology 1983;85:917-21.
22. Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis : a pathologic and clinical entity. JAMA 1932;99:1323.
23. Surawicz CM, Meisel JL, Ylvisaker T, Saunders DR, Rubin CE. Rectal biopsy in the diagnosis of Crohn's disease : value of multiple biopsies and serial sectioning. Gastroenterology 1981;81: 66-71.
24. Surawicz CM. Serial sectioning of a portion of a rectal biopsy detects more focal abnormalities. A prospective study of patients with inflammatory bowel disease. Dig Dis Sci 1982;27:434-6.
25. Surawicz CM. The role of rectal biopsy in infectious colitis. Am J Surg Pathol 1988;12:82-8.
26. st year after presentation. Scand J Gastroenterol 1994;29:318-32.
27. Lee FD, Maguire C, Obeidat W, Russell RI. Importance of cryptolytic lesions and pericryptal granulomas in inflammatory bowel disease. J Clin Pathol 1997;50:148-52.
28. Rotterdam H, Korelitz BI, Sommers SC. Microgranulomas in grossly normal rectal mucosa in Crohn's disease. Am J Clin Pathol 1977;67:550-4.
29. Gledhill A, Dixon MF. Crohn's-like reaction in diverticular disease. Gut 1998;42:392-5.
30. Makapugay LM, Dean PJ. Diverticular disease-associated chronic colitis. Am J Surg Pathol 1996;20:94-102.
31. Goldman H, Antonioli DA. Mucosal biopsy of the rectum, colon and distal ileum. Hum Pathol 1982;13:981-1012.
32. Schmitz-Moormann P, Pittner PM, Malchow H, Brandes JW. The granuloma in Crohn's disease. A bioptical study. Pathol Res Pract 1984;178:467-76.
33. Schmitz-Moormann P, Schäg M. Histology of the lower intestinal tract in Crohn's disease of children and adolescents. Multicentric paediatric Crohn's disease study. Pathol Res Pract 1990;186:479-84.
34. Wakefield AJ, Sankey EA, Dhillon AP, Sawyerr AFM, More L, Sim R, et al. Granulomatous vasculitis in Crohn's disease. Gastroenterology 1991;100:1279-87.
35. Mooney EE, Walker J, Hourinane DOB. Relation of granulomas to lymphatic vessels in Crohn's disease. J Clin Pathol 1995;48: 335-8.
36. Geboes K, Van Den Oord J, De Wolf-Peeters C, Desmet V, Rutgeerts P, Janssens J, et al. The cellular composition of granulomas in mesenteric lymph nodes from patients with Crohn's disease. Virchows Arch Pathol Anat 1986;409:679-92.
37. Hara J, Ohtani H, Matsumoto T, Nakamura S, Kitano A, Arakawa T, et al. Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease : demonstration of cell-to-cell contact with T lymphocytes. Lab Invest 1997;77: 175-84.
38. Soler P, Bernaudin JF. Physiologie des granulomes. Rev Pneumol Clin 1993;49:257-61.
39. Bergeron A, Bonay M, Kambouchner M, Lecossier D, Riquet M, Soler P, et al. Cytokine patterns in tuberculous and sarcoid granulomas. Correlation with histopathologic features of the granulomatous response. J Immunol 1997;159:3034-43.
40. De Chadarévian JP, Raphael SA, Murphy GF. Histologic, ultrastructural, and immunocytochemical features of the granulomas seen in a child with the syndrome of familial granulomatous arthritis, uveitis, and rash. Arch Pathol Lab Med 1993;117:1050-2.
41. Mielke MEA, Rosen H, Brocke S, Peters C, Hahn H. Protective immunity and granuloma formation are mediated by two distinct tumor necrosis factor alpha-and gamma-interferon-dependent T cell-phagocyte interactions in murine listeriosis : dissociation of the basis of phagocyte adhesion mechanisms. Infect Immun 1992;60:1875-82.
42. Mishra L, Mishra BB, Harris M, Bayless TM, Muchmore AV. In vitro cell aggregation and cell adhesion molecules in Crohn's disease. Gastroenterology 1993;104:772-9.
43. Fais S, Pallone F. Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines. Gut 1995;37:798-801.
44. Myatt N, Coghill G, Morrison K, Jones D, Cree IA. Detection of tumour necrosis factor in sarcoidosis and tuberculosis granulomas using in situ hybridisation. J Clin Pathol 1994;47:423-6.
45. Rumbley CA, Zekavat SA, Sugaya H, Perrin PJ, Ramadan MA, Phillips SM. The schistosome granuloma : characterization of lymphocyte migration, activation, and cytokine production. J Immunol 1998;161:4129-37.
46. Chensue SW, Warmington KS, Berger AE, Tracey DE. Immunohistochemial demonstration of interleukin-1 receptor antagonist protein and interleukin-1 in human lymphoid tissue and granulomas. Am J Pathol 1992;140:269-74.
47. Van Patter WN, Bargen JA, Dockerty MB, Feldman WH, Mayo CW, Waugh JM. Regional enteritis. Gastroenterology 1954;26: 347-75.
48. Antonius JL, Gump FE, Lattes R, Lepor M. A study of certain microscopic features in regional enteritis, and their possible prognostic significance. Gastroenterology 1960;38:889-905.
49. Kyle J. Prognosis after ileal resection for Crohn's disease. Br J Surg 1971;58:735-7.
50. Gump FE, Sakellariadis P, Wolff M, Broell JR. Clinical-pathological investigation of regional enteritis as a guide to prognosis. Ann Surg 1971;176:233-42.
51. Assarsson N, Räf L. Incidence of granuloma in Crohn's disease. Acta Chir Scand 1974;140:249-51.
52. Glass RE, Baker WNW. Role of the granuloma in recurrent Crohn's disease. Gut 1976;17:75-7.
53. Homan WP, Gray GF, Dineen P. Granulomas in Crohn's disease. Lancet 1978;1:112.
54. Wolfson DM, Sachar DB, Cohen A, Goldberg J, Styczynski R, Greenstein AJ, et al. Granulomas do not affect postoperative recurrence rates in Crohn's disease. Gastroenterology 1982;83: 405-9.
55. Chong SKF, Blackshaw AJ, Boyle S, Williams CB, Walker-Smith JA. Histological diagnosis of chronic inflammatory bowel disease in childhood. Gut 1985;26:55-9.
56. Heimann TM, Miller F, Martinelli G, Szporn A, Greenstein AJ, Aufses AH. Correlation of presence of granulomas with clinical and immunologic variables in Crohn's disease. Arch Surg 1988;123:46-8.
57. Kelly JK, Sutherland LR. The chronological sequence in the pathology of Crohn's disease. J Clin Gastroenterol 1988;10:28-33.
58. Roberts PL, Schoetz DJ, Pricolo R, Veidenheimer MC. Clinical course of Crohn's disease in older ptients. A retrospective study. Dis Colon Rectum 1990;33:458-62.
59. Smedh K, Olaison G, Franzén L, Sjödahl R. The endoscopic picture reflects transmural inflammation better than endoscopic biopsy in Crohn's disease. Eur J Gastroenterol Hepatol 1996;8: 1189-93.
60. Anseline PF, Wlodarczyk J, Murugasu R. Presence of granulomas is associated with recurrence after surgery for Crohn's disease : experience of a surgical unit. Br J Surg 1997;84:78-82.
61. Griffiths AM, Wesson DE, Shandling B, Corey M, Sherman PM. Factors influencing postoperative recurrence of Crohn's disease in childhood. Gut 1991;32:491-5.
62. Meessen JP, Jouret-Mourin A, Vanheuverzwyn R, Jungers M, Fiasse R, Haot J. Apport des biopsies rectales et coliques dans le diagnostic de la maladie de Crohn. Acta Gastroenterol Belg 1987;11:211-7.
63. Markowitz J, Kahn E, Daum F. Prognostic significance of epithelioid granulomas found in rectosigmoid biopsies at the initial presentation of pediatric Crohn's disease. J Pediatr Gastroenterol Nutr 1989;9:182-6.
64. Pötzi R, Walgram M, Lochs H, Holzner H, Gangl A. Diagnostic significance of endoscopic biopsy in Crohn's disease. Endoscopy 1989;21:60-2.
65. Keller KM, Bender SW, Kirchmann H, Ball F, Schmitz-Moormann P, Wirth S, et al. and Multicenter Paediatric Crohn's Disease Study Group. Diagnostic significance of epithelioid granulomas in Crohn's disease in children. J Pediatr Gastroenterol Nutr 1990;10:27-32.
66. Jouret A, Mainguet P. Valeur diagnostique de la biopsie endoscopique systématique dans la maladie de Crohn (MC) iléocolique (résumé). Gastroenterol Clin Biol 1993;17:A12.
67. Geboes K, Vantrappen G. The value of colonoscopy in the diagnosis of Crohn's disease. Gastrointest Endosc 1975;22:18-23.
68. Colombel JF, Dupas JL, Cortot A, Salomez JL, Marti R, Gower-Rousseau C, et al. Incidence des maladies inflammatoires du tube digestif dans la région Nord-Pas de Calais et le département de la Somme (1988). Gastroenterol Clin Biol 1990;14:614-8.
69. Pagenault M, Tron I, Alexandre JL, Cruchant E, Dabadie A, Chaperon J, Robaszkiewicz M, Bretagne JF et Abermad. Incidence des maladies inflammatoires du tube digestif en Bretagne (1994-1995). Gastroenterol Clin Biol 1997;21:483-90.
70. Flamenbaum M, Zénut M, Aublet-Cuvelier B, Larpent JL, Fabre P, Groupe EPIMICI, Abergel A, Dapoigny M, Bommelaer G. Incidence des maladies inflammatoires du tube digestif dans le département du Puy-de-Dôme en 1993 et 1994. Gastroenterol Clin Biol 1997;21:491-6.
71. Ramzan NN, Leighton JA, Heigh RL. Clinical significance of granuloma in Crohn's disease. Am J Gastroenterol 1998;93:1669.
72. Danzy JT, Farmer RG, Sullivan BH, Rankin GB. Endoscopic features of gastroduodenal Crohn's disease. Gastroenterology 1976;70:9-13.
73. Korelitz BI, Waye JD, Kreuning J, Sommers SC, Fein HD, Beeber J, et al. Crohn's disease in endoscopic biopsies of gastric antrum and duodenum. Am J Gastroenterol 1981;76:103-9.
74. Sommers SC, Korelitz BI. Duodenal biopsy cell counts and histopathology in Crohn's disease. In : Pena AS, Weterman IT, Booth CC, Strober W, eds. Recent advances in Crohn's diseases. The Hague : Martinus Nijhoff, 1981:47-51.
75. Hermann A, Burette A, Van Wetere P, Osmani A, De Reuck M, Deltenre M. Gastroduodenal lesions associated with intestinal Crohn's disease : correlation X-ray-endoscopy (Abstract). Vth International Symposia of Digestive Endoscopy, Brussels, 1982.
76. Geboes K, Rutgeerts P, Vantrappen G. Evaluation de l'atteinte du tractus supérieur dans la maladie de Crohn. Acta Endosc 1983;13:269-73.
77. Lossing A, Langer B, Jeejeebhoy KN. Gastroduodenal Crohn's disease : diagnosis and selection of treatment. Can J Surg 1983;26:358-60.
78. Schmitz-Moormann P, Malchow H, Pittner PM. Endoscopic and bioptic study of the upper gastrointestinal tract in Crohn's disease patients. Pathol Res Pract 1985;178:377-87.
79. Jouin H, Baumann R, Abbas A, Duclos B, Weill-Bousson M, Weill JP. Les localisations œsogastroduodénales de la maladie de Crohn sont fréquentes. Gastroenterol Clin Biol 1986;10:549-53.
80. Gad A. The diagnosis of gastroduodenal Crohn's disease by endoscopic biopsy. Scand J Gastroenterol 1989;24:23-8.
81. D'Haens G, Rutgeerts P, Geboes K, Vantrappen G. The natural history of esophageal Crohn's disease : three patterns of evolution. Gastrointest Endosc 1994;40:296-300.
82. Meining A, Bayerdörffer E, Bästlein E, Raudis N, Thiede C, Cyrus B, et al., and Crohn's Disease Study Group, Germany. Focal inflammatory infiltrations in gastric biopsy specimens are suggestive of Crohn's disease. Scand J Gastroenterol 1997;32:813-8.
83. Oberhuber G, Püspök A, Oesterreicher C, Novacek G, Zauner C, Burghuber M, et al. Focally enhanced gastritis : a frequent type of gastritis in patients with Crohn's disease. Gastroenterology 1997;112:698-706.
84. Wagtmans MJ, Verspaget HW, Lamers CBHW, Van Hogezand RA. Clinical aspects of Crohn's disease of the upper gastrointestinal tract : a comparison with distal Crohn's disease. Am J Gastroenterol 1997;92:1467-71.
85. Weterman IT. Oral, esophageal and gastroduodenal Crohn's disease. In : Allan RN, Keighley MRB, Alexander-Williams J, et al., eds. Inflammatory bowel diseases. New York : Churchill-Livingstone, 1990:319-27.
86. Chambers TJ, Morson BC. The granuloma in Crohn's disease. Gut 1979;20:269-74.
87. Warren S, Sommers SC. Cicatrizing enteritis (regional ileitis) as a pathological entity, analysis of 120 cases. Am J Pathol 1948;24: 475-502.
88. Rappaport H, Burgoyne FH, Smetana HF. The pathology of regional enteritis. Milit Surg 1951;109:463-99.
89. Chapin LE, Scudamore HH, Baggenstoss AH, Bargen JA. Regional enteritis : associated visceral changes. Gastroenterology 1956;30:404-15.
90. Dordal E, Glagov S, Kirsner JB. Hepatic lesions in chronic inflammatory bowel disease. Gastroenterology 1967;52:239-53.
91. Eade MN, Cooke WT, Williams JA. Liver disease in Crohn's disease. A study of 100 consecutive patients. Scand J Gastroenterol 1971;6:199-204.
92. Maurer LH, Hughes RW, Folley JH, Mosenthal WT. Granulomatous hepatitis associated with regional enteritis. Gastroenterology 1967;53:301-5.
93. Eade MN. Liver disease in ulcerative colitis. I-Analysis of operative liver biopsy in 138 consecutive patients having colectomy. Ann Intern Med 1970;72:475-87.
94. Kuramoto S, Oohara T, Ihara O, Shimazu R, Kondo Y. Granulomas of the gut in Crohn's disease. A step sectioning study. Dis Colon Rect 1987;30:6-11.
95. Smedh K, Olaison G, Franzén L, Sjödahl R. Endoscopic and external bowel changes and histopathology in patients with Crohn's disease. Br J Surg 1995;82:191-4.
96. Okada M, Maeda K, Yao T, Iwashita A, Nomiyama Y, Kitahara K. Minute lesions of the rectum and sigmoid colon in patients with Crohn's disease. Gastrointest Endosc 1991;37:319-24.
97. Kramer K, Petras E, Kotanogi H, Fazio V. Granulomatous versus non-granulomatous Crohn's disease : a clinicopathologic study of 185 cases. Lab Invest 1990;62:55A.
98. Babaryka I, Thorn L, Langer E. Epithelioid cell granulomata in the mucosa of the small intestine in Whipple's disease. Virchows Arch A Pathol Anat Histol 1979;382:227-35.
99. Ectors N, Geboes K, Wynants P, Desmet V. Granulomatous gastritis and Whipple's disease. Am J Gastroenterol 1992;87:509-13.
100. Shepherd NA. Pathological mimics of chronic inflammatory bowel disease. J Clin Pathol 1991;44:726-33.
101. Temmesfeld-Wollbrueck B, Heinrichs C, Szalay A, Seeger W. Granulomatous gastritis in Wegener's disease : differentiation from Crohn's disease supported by a positive test for antineutrophil antibodies. Gut 1997;40:550-3.
102. Boruchowicz A, Wallaert B, Vandermolen P, Colombel JF. Sarcoïdose et tube digestif. Gastroenterol Clin Biol 1994;18:1119-28.
103. Watson DW, Friedman HM, Quigley A. Immunological studies in a patient with ulcerative colitis and sarcoidosis. Gut 1972;56:583.
104. McCormick PA, O'Donoghue DP, Fitzgerald MX. Crohn's colitis and sarcoïdosis. Postgrad Med J 1986;62:951-3.
105. Grönhagen-Riska C, Fyhrquist F, Hortling L. Familial occurrence of sarcoidosis and Crohn's-disease. Lancet 1983;2:1287-8.
106. Bamberry P, Kaur U, Bhusnurmath SR, Dilawari JB. Familial idiopathic granulomatosis : sarcoidosis and Crohn's disease in two Indian families. Thorax 1991;46:919-21.
107. Werlin SL, Chusid MJ, Caya J, Oechler HW. Colitis in chronic granulomatous disease. Gastroenterology 1982;82:328-31.
108. Sloan JM, Cameron CHS, Maxwell RJ, McCluskey DR, Collins JSA. Colitis complicating chronic granulomatous disease. A clinicopathological case report. Gut 1996;38:619-22.
109. Ament ME, Ochs HD. Gastrointestinal manifestations of chronic granulomatous disease. N Engl J Med 1973;288:382-7.
110. Yogman MW, Touloukian RJ, Gallagher R. Intestinal granulomatosis in chronic granulomatous disease and in Crohn's disease. N Engl J Med 1974;289:228.
111. Werlin SL, Chusid MJ, Caya J, Oechler HW. Colitis in chronic granulomatous disease. Gastroenterology 1982;82:328-31.
112. Harris BH, Boles ET. Intestin allesions in chronic granulomatous disease of childhood. J Pediatr Surg 1973;8:955.
113. Griscom NT, Kirkpatrick JA, Girdany BR, Berdon WE, Grand RJ, Mackie GG. Gastric antral narrowing in chronic granulomatous disease. Pediatrics 1971;54:456-60.
114. Vannier JP, Arnaud-Battandier F, Ricour C, Schmitz J, Buriot D, Griscelli C, et al. Neutropénie primitive et congénitale et maladie de Crohn. A propos de deux observations chez l'enfant. Arch Fr Pediatr 1982;39:367-70.
115. Couper R, Kapelushnik J, Griffiths AM. Neutrophil dysfunction in glycogen storage disease Ib : association with Crohn's-like colitis. Gastroenterology 1991;100:549-54.
116. Wendel U, Bremer HJ. Inflammatory bowel disease in glycogen storage disease type 1b. J Pediatr 1987;2:166.
117. Dwarakanath AD, Nash J, Rhodes JM. « Conversion » from ulcerative colitis to Crohn's disease associated with corticosteroid treatment. Gut 1994;35:1141-4.
118. Baert F, Hart J, Blackstone MO. A case of diclofenac-induced colitis with focal granulomatous change. Am J Gastroenterol 1995;90:1871-3.
119. Bouhnik Y, Lémann M, Mary JY, Scemama G, Taï R, Maluchansky C, et al. Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Lancet 1996;347:215-9.
120. D'Haens GR, Gasparaitis AE, Hanauer SB. Duration of recurrent ileitis after ileocolonic resection correlates with presurgical extent of Crohn's disease. Gut 1995;36:715-7.
121. François Y, Gaujoux F, Descos L, Vignal J. Crohn perforant. Crohn non perforant. Mythe ou réalité ? Lyon Chir 1990;86:386-9.
122. Heuman R, Boeryd B, Bolin T, Sjödahl R. The influence of disease at the margin of resection on the outcome of Crohn's disease. Br J Surg 1983;70:519-21.
123. Kotanagi H, Kramer K, Fazio VW, Petras RE. Do microscopic abnormalities at resection margins correlate with increased anastomotic recurrence in Crohn's disease ? Dis Colon Rectum 1991;34:909-16.
124. Lindhagen T, Ekelund G, Leandoer L, Hildell J, Lindström C, Wenckert A. Recurrence rate after surgical treatment of Crohn's disease. Scand J Gastroenterol 1983;18:1037-44.
125. Prantera C, Levenstein S, Capocaccia R, Mariotti S, Luzi C, Cosintino R, et al. Prediction of surgery for obstruction in Crohn's ileitis. A study of 64 patients. Dig Dis Sci 1987;32:1363-9.
126. Scott ADN, Ritchie JK, Phillips RKS. Blood transfusion and recurrent Crohn's disease. Br J Surg 1991;78:455-8.
127. Shivananda S, Hordijk ML, Pena AS, Mayberry JF. Crohn's disease : risk of recurrence and reoperation in a defined population. Gut 1989;30:990-5.
128. Trnka YM, Glotzer DJ, Kasdon EJ, Goldman H, Steer ML, Goldman LD. The long-term outcome of restorative operation in Crohn's disease. Influence of location, prognostic factors and surgical guidelines. Ann Surg 1982;196:345-55.
129. Softley A, Myren J, Clamp SE, Bouchier IAD, Watkinson G, de Dombal FT. Factors affecting recurrence after surgery for Crohn's disease. Scand J Gastroenterol 1988;23:31-4.