Synthesis of sesquiterpene derivatives as potential antitumor agents; elemane derivatives

Archives of Pharmacal Research

Volumn 22, Issue 6, 1999, Pages 575-578

  Choi, Bo Gil ^a   Kwak, Eun Yee ^a   Chung, Byung Ho ^a   Cho, Won Jea ^a   Cheon, Seung Hoon ^a  

^a Chonnam National University   (South Korea)

Author keywords

Antitumor agent; Elema 1,3 diene; Santonin; Elemene

Indexed keywords

ANTINEOPLASTIC AGENT; SESQUITERPENE;

ARTICLE; CHEMISTRY; SYNTHESIS;

ANTINEOPLASTIC AGENTS; SESQUITERPENES;

EID: 0033251108     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975329     Document Type: Article

References (12)

1. Cardona, L., Garcia, B., Gimenez, J. E., and Pedro, J. R., A shorter route to the synthesis of (+)-Junenol, Isojunenol, and their coumarate esters from (-)-santonin, Tetrahedron, 48, 851 (1992).
2. Fu, N. W., Jin, L. P. and Huo, Y. T., Antitumor and pharmacological studies of β-elemene, Bull. Chin. Med., 9, 35 (1994).
3. Grieco, P. A. and Nishizawa, M., Total synthesis of (+)-Costunolide, J. Org. Chem., 42, 1717-1720 (1977).
4. Jia, W. M., Yang, L. M., Li, Z. H. and Hu, J. H., Synthesis of the antitumor β-elemene derivatives, Youji Huaxue, 11, 608-610 (1991).
5. McMurray, J. E., and Kocovsky, P., Synthesis of helmithogermacrene and β-elemene, Tetrahedron Lett., 26, 2171 (1985).
6. Patel, L. J., Kulkarni, K. S., and Rao, A. S., Tepenoids: Part LXXVIII-Synthesis of Tetrahydroelemol, Indian J. Chem., 4, 400 (1988).
7. Qian, J. Pharmacology and clinical studies of β-elemene, a new anticancer agent, Chin. J. Clin. Oncol., 23, 453-5 (1996).
8. Shi, J. H. Pharmacological studies on antitumor activities of β-elemene, Bull. Chin. Med., 2, 32 (1981)
9. Simomovic, D. M., Somasekar, R. and Bnattacharyya, Terpenoids-XXXIX, Tetrahedron, 19, 1061 (1963)
10. Wang, X. W., Elemene, Drugs of the Future, 23, 266-270 (1998).
11. Xu, H. U., Li, J., and Tun, L., Effect of elemene on serum superoxide dismutase activity in patients with with brain tumors, Chin. J. Clin. Oncol., 23, 527-9 (1996)
12. Zuo, Y., The Study of elemene of induction apoptosis on ascites hepatoma cell line Hca-F25/Cl-16A3, Chin. J. Cancer Res., 9, 10-13 (1998).