Asymmetric borane reduction of prochiral ketones using aluminum triethoxide and chiral amino alcohols

Chemistry Letters

Volumn , Issue 11, 1999, Pages 1203-1204

  Yanagi, Takashi ^a   Kikuchi, Ken ^a   Takeuchi, Hideki ^a   Ishikawa, Takehiro ^a   Nishimura, Toshihiro ^a   Kamijo, Tetsuhide ^a  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033235083     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.1999.1203     Document Type: Article

References (11)

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7. 2. After a borane-dimethyl sulfide complex (5 mmol) was added, a solution of a ketone (5 mmol) in 10 mL of dry THF was added dropwise via a syringe pump over 1 h. The reaction mixture was stirred until the ketone disappeared on a TLC. The resulting mixture was quenched with 1M HC1 or triethanolamine. The usual workup provided the chiral alcohol.
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