The design and synthesis of sulfur containing bisphosphonic acids for the treatment of arthritis

Phosphorus, Sulfur and Silicon and Related Elements

Volumn 144-146, Issue , 1999, Pages 325-328

  Almstead, Neil G ^a   Dansereau, Susan M ^a   Francis, Marion D ^a   Snider, Catherine M ^a   Ebetino, Frank H ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Antiinflammatory; Arthritis; Bisphosphonate

Indexed keywords

EID: 0033234609     PISSN: 10426507     EISSN: None     Source Type: Journal    
DOI: 10.1080/10426509908546247     Document Type: Article

References (9)

1. Geddes, A. D.; D'Souza, S. M.; Ebetino, F. H.; Ibbotson, K. J. In Bone and Mineral Research, edited by J. N. M. Heersche and J. A. Kanis (Elsevier Science BV, 1994), Vol. 8, pp 265.
2. Francis, M. D.; Hovancik, K.; Boyce, R. W. Int. J. Tiss. Reac. XI, 239 (1989).
3. (a) Tanahashi, M.; Funaba, Y.; Itoh, M. Norio, K.; Nakadate-Matsushita, T. Pharmacology, 56, 242 (1998).
4. (b) Schlachter, S. T.; Galinet, L. A.; Shields, S. K.; Aspar, D. G.; Dunn, C. J.; Staite, N. D.; Nugent, R. A. Biorg. Med. Chem. Lett., 8, 1093 (1998).
5. Sietsema, W. K.; Ebetino, F. H. Expert Opin. Invest. Drugs., 3, 1255 (1994).
6. Inhibition of the MMPs by bisphosphonates has previously been disclosed. See: Teronen, O.; Kontinnen, Y. T.; Lindqvist, C.; Salo, T.; Lauhio, A.; Ding, Y.; Santavirta, S.; Sorsa, T. J. Dent. Res., 16, 1529 (1997).
7. Inhibition of MMPs may provide a therapeutic benefit for the treatment of arthritis. See: Cawston, T.E. Pharmacol. Ther. 70, 163 (1996).
8. Degenhardt, C.R.; Burdsall, D. C. J. Org Chem. 51, 3488, (1986).
9. No dose-ranging studies were performed with the thio-bisphosphonic acids, therefore the lowest effective dose for these compounds has not been determined.