NPY Y2 receptor agonist, N-acetyl [Leu28,Leu31]NPY24-36, reduces renal vasoconstrictor activity in anaesthetised dogs

Journal of the Autonomic Nervous System

Volumn 78, Issue 1, 1999, Pages 10-17

  Mahns, David A ^a   Kelly, Catherine ^a   McCloskey, D I ^a   Potter, Erica K ^a  

^a NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

NPY; Renal blood flow; Y2 agonist

Indexed keywords

NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROTRANSMITTER; DRUG DERIVATIVE; NEUROPEPTIDE Y; NEUROPEPTIDE Y (24 36), AC (LEU(28,31)); NEUROPEPTIDE Y (24-36), AC-(LEU(28,31))-; NEUROPEPTIDE Y RECEPTOR; PEPTIDE FRAGMENT; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOG; DRUG RECEPTOR BINDING; FEMALE; GLOMERULUS FILTRATION RATE; KIDNEY CIRCULATION; MALE; NERVE CONDUCTION; NERVE ENDING; NERVE POTENTIAL; NERVE STIMULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; SYMPATHETIC NERVE; VASOCONSTRICTION; ADRENERGIC SYSTEM; ANESTHESIA; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; ELECTROSTIMULATION; INNERVATION; PHYSIOLOGY; REFLEX; RENAL ARTERY; STIMULATION;

ANESTHESIA; ANIMALS; DOGS; ELECTRIC STIMULATION; FEMALE; GLOMERULAR FILTRATION RATE; MALE; NEUROPEPTIDE Y; PEPTIDE FRAGMENTS; RECEPTORS, NEUROPEPTIDE Y; REFLEX; RENAL ARTERY; RENAL CIRCULATION; RENIN; STIMULATION, CHEMICAL; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION;

EID: 0033233470     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(99)00056-9     Document Type: Article

References (32)

1. Allen J.M., Raine A.E., Ledingham J.G., Bloom S.R. Neuropeptide Y: a novel renal peptide with vasoconstrictor and natriuretic activity. Clin. Sci. 68:1985;373-377.
2. Aubert J.F., Burnier M., Maeber B., Nussberger B., Dipette D.J., Burris J.F., Brunner H.R. Effects of a nonpressor dose of neuropeptide Y on cardiac output, regional blood flow distribution and plasma renin, vasopressin and catecholamine levels. J. Pharmacol. Exp. Ther. 244:1988;1109-1115.
3. Ballesta J., Polak J.M., Allen J.M., Bloom S.R. The nerves of the juxtaglomerular apparatus of man and other mammals contain the potent peptide NPY. Histochemistry. 80:1984;483-485.
4. Bischoff A., Michel M.C. Renal effects of neuropeptide Y. Pfluegers Arch. 435:1998;443-453.
5. Bischoff A., Stickan-VerfOrth M., Michel M.C. Renovascular and tubular effects of Neuropeptide Y are discriminated by PP56 (D-myo-inositol 1,2,6-triphosphate) in anaesthetised rats. Pfluegers Arch. 434:1997;57-62.
6. Callanan D., Read D.J. The role of arterial chemoreceptors in the breath-by-breath augmentation of inspiratory effort in rabbits during airway occlusion or elastic loading. J. Physiol. 241:1974;33-44.
7. Coppes R.P., Smit J., Geurtsen A.M., Roffel A.F., Dahlof C., Doods H.N., Zaagsrna J. Heterogeneity of prejunctional neuropeptide Y receptors inhibiting noradrenaline overflow in the portal vein of freely moving rats. Eur. J. Pharmacol. 261:1991;311-316.
8. Doods H.N., Krause J. Different neuropeptide Y receptor subtypes in rat and rabbit vas deferens. Eur. J. Pharmacol. 204:1991;101-103.
9. Edvinsson L., Ekblad E., Hakanson R., Wahlestedt C. Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br. J. Pharmacol. 83:1984;519-525.
10. Haymet B.T., McCloskey D.I. Baroreceptor and chemoreceptor influence on heart rate during the respiratory cycle in the dog. J. Physiol. 245:1975;699-712.
11. Kon V., Ichikawa I. Effector loci for renal nerve control of cortical circulation. Am. J. Physiol. 245:1983;F545-F553.
12. 2 prejunctional receptor. Br. J. Pharmacol. 113:1994;479-484.
13. Lew M.A., Angus J.A. Functional evidence for at least 5 distinct NPY family receptors in the rat mesenteric artery and vas deferens. Regul. Pept. 71:1997;214-217.
14. Lumbers E.R., Lee Lewes J. The actions of vasoactive drugs on fetal and maternal plasma renin activity. Biol. Neonate. 35:1979;23-32.
15. 3H -noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens Acta Physiol. Scand. 120:1984;477-479.
16. Lundberg J.M., Tatemoto K. Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to alpha-adrenoceptor blockade. Acta Physiol. Scand. 116:1982;393-402.
17. Lundberg J.M., Terenius L., Hokfelt T., Goldstein M. High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci. Lett. 42:1983;167-172.
18. Lundberg J.M., Torssell L., Sollevi A., Pernow J., Theodorsson Norheim E., Anggard A., Hamberger B. Neuropeptide Y and sympathetic vascular control in man. Regul. Pept. 13:1985;41-52.
19. 2 receptor agonist in the gracilis muscle of anaesthetised dogs. J. Auton. Nerv. Syst. 68:1998;14-20.
20. McLachlan E.M., Luff S.L. Sympathetic innervation of renal and extrarenal arterial vessels. Kidney Int., Suppl. 37:1992;S56.
21. Norvell J.E., MacBride R.G. Neuropeptide Y (NPY)-like immunoreactive nerve fibers in the human and monkey (Macaca fascicularis) kidney. Neurosci. Lett. 105:1989;63-67.
22. Oellerich W.F., Malik K.U. Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney. J. Pharmacol. Exp. Ther. 266:1993;1321-1329.
23. Pernow J., Lundberg J.M. Release and vasoconstrictor effects of Neuropeptide Y in relation to non-adrenergic sympathetic control of renal blood flow in the pig. Acta Physiol. Scand. 136:1989;507-517.
24. Potter E.K. Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: neuromodulation by neuropeptide Y? Neurosci. Lett. 54:1985;117-121.
25. 2) receptor. Eur. J. Pharmacol. 267:1994;253-262.
26. Reinecke M., Forssmann W.G. Neuropeptide (neuropeptide Y, neurotensin, vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide, somatostatin) immunohistochemistry and ultrastructure of renal nerves. Histochemistry. 89:1994;1-9.
27. Rump L.C., Riess M., Schwertfeger E., Michel M.C., Bohmann C., Schollmeyer P. Prejunctional neuropeptide Y receptors in human kidney and atrium. J. Cardiovasc. Pharmacol. 29:1997;656-661.
28. Skinner S. Improved assay methods for renin, concentration and activity in human plasma. Methods using selective denaturation of renin substrate. Circ. Res. 20:1967;391-402.
29. Sun X.Y., Edvinsson L., Yoo H., Wahlestedt C., Hedner J. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. J. Cardiovasc. Pharmacol. 25:1995;696-704.
30. Wahlestedt C., Häkanson R. Effects of neuropeptide Y (NPY) at the sympathetic neuroeffector junction. Can pre- and postjunctional receptors be distinguished? Med. Biol. 64:1986;85-88.
31. Wahlestedt C., Yanaihara N., Häkanson R. Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul. Pept. 13:1986;307-318.
32. Warner M.R., Levy M.N. Neuropeptide Y as a putative modulator of the vagal effects on heart rate. Circ. Res. 64:1989;882-895.