Experience with high dose dexamethasone in the treatment of chronic symptomatic immune thrombocytopaenia

East African Medical Journal

Volumn 76, Issue 10, 1999, Pages 571-574

  Van Riet, F A D ^a   Wessels, G ^a   Hesseling, P B ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; IMMUNOGLOBULIN;

ARTICLE; BLOOD; BONE MARROW EXAMINATION; CHILD; CHRONIC DISEASE; DRUG EFFECT; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INFANT; INTRAVENOUS DRUG ADMINISTRATION; MALE; PATIENT SELECTION; PRESCHOOL CHILD; SPLENECTOMY; THROMBOCYTE COUNT; TREATMENT OUTCOME;

ANTI-INFLAMMATORY AGENTS; BONE MARROW EXAMINATION; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; DEXAMETHASONE; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFANT; INFUSIONS, INTRAVENOUS; MALE; PATIENT SELECTION; PLATELET COUNT; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SPLENECTOMY; TREATMENT OUTCOME;

EID: 0033233355     PISSN: 0012835X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Walker, R.W. and Walker, W. Idiopathic thrombocytopenia, initial illness and long-term follow up. Arch. Dis. Child. 1984; 59: 316.
2. Madeiros, D. and Buchanan, G.R. Current controversies in the management of idiopathic thrombocytopenic purpura during childhood. Paediat. clin. N. Amer. 1996; 43: 757.
3. Reid, M.M. Chronic idiopathic thrombocytopenic purpura: incidence, treatment and outcome. Arch. Dis. Child. 1995; 72: 125.
4. Von dem Borne, A.E.G.K., Vos, J.J.E., Pegels, J.G., Thomas, L.L.M. and Van der Lelie, H. High dose intravenous methylprednisolone or high dose intravenous gammaglobulin in autoimmune thrombocytopenia. Brit. Med. J. 1988; 296: 249.
5. Kurtzberg, J., Friedman, H.S., Chaffee, S., Falletta, J.M., Kinney, T.R., Kurlander, R., Matthews, T.J. and Schwartz, R.S. Efficacy of intravenous gamma globulin in autoimmune-mediated pediatric blood dyscrasias. Amer. J. Med. 1987; 83: 4.
6. Mobini N, Sarela A, Ahmed AR. Intravenous immunoglobulins in the therapy of autoimmune and systemic inflammatory disorders. Ann. Allerg. Asthma. Imm. 1995; 74: 119.
7. Fenaux, P., Caulier, M.T., Hirschauer, M.C., Beuscart, R., Goudemand, J. and Bauters, F. Re-evaluation of the prognostic factors for splenectomy in chronic idiopathic thrombocytopenic purpura (ITP): a report of 181 cases. Eur. J. Haemat. 1989; 42: 259.
8. Anderson, J.C. Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy. N. Engl. J. Med. 1994; 330: 1560.
9. Kuhne, T., Freedman, J., Semple, J., Doyle, J. and Butchart, S. Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura. J. Paediat. 1997; 130: 17.
10. Borgna-Pignatti, C., Rugolotto, S. and Nobili, B. A trial of high-dose dexamethasone therapy for chronic idiopathic thrombocytopenic purpura in childhood. J. Paediat. 1997; 130: 13.
11. Chen, J.S., Wu, J.M. and Chen, Y.J. Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura. J. Paediat. Oncol. 1997; 19: 526.
12. Schreiber, A., Chien, P., Tomaski, A., Cines, D.B. Effect of danazol in immune thrombocytopenic purpura. N. Engl J. Med. 1987; 9: 500.
13. Ahn, Y.S., Harrington, W.J., Mylvaganam, R., Allen, L.M., Pall, L.M. Slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura. Amer. J. Intern. Med. 1984; 100: 192.
14. Kelsey, P.R., Schofield, K.P. and Geary, C.G. Refractory idiopathic thrombocytopenic purpura treated with cyclosporine. Brit. J. Haemat. 1985; 60: 197.
15. Berchtold, P. and McMillan, R. Therapy of chronic idiopathic ihrombocytopenic purpura in adults. Blood. 1989; 74: 2309.
16. Salama, A., Kiefel, V. and Mueller-Eckhardt, C. Treatment of autoimmune thrombocytopenic purpura with Rhesus antibodies (anti-Rho-D). Blut. 1984; 49: 29.
17. Cohn, R.J., Schwyzer, R., Hesseling, P.B., Poole, J.E., Naidoo, J. and Van Heerden, C. Alfainterferon for severe chronic idiopathic thrombocytopenic purpura in children. Amer. J. Haemat. 1993; 43: 246.
18. Stuart, M.J. and Kelton, J.G. The platelet: quantitative and qualitative abnormalities. In: Haematology of Infancy and Childhood. (Third edition) (eds) Nathan D.G. and Oski F.A. WB Sanders Company, Philadelphia, 1987.