The molecular structure of 2α-hydroxyneoanisatin and structure-activity relationships among convulsant sesquiterpenes of the seco-prezizaane and picrotoxane types

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2857-2865

  Schmidt, Thomas J ^a   Okuyama, Emi ^b   Fronczek, Frank R ^c  

^a Inst Pharmazeut Biol Heinrich H   (Germany)

^b CHIBA UNIVERSITY   (Japan)

^c LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Convulsants; Crystal structure; GABA antagonists; Molecular modelling; Natural products; Terpenes; X ray

Indexed keywords

2ALPHA HYDROXYNEOANISATIN; ANISATIN; CONVULSANT AGENT; ILLICIUM FLORIDANUM EXTRACT; NATURAL PRODUCT; NEUROTOXIN; PICROTOXANE; PICROTOXININ; PLANT EXTRACT; PREZIZAANE; SESQUITERPENE LACTONE; UNCLASSIFIED DRUG; 2 HYDROXYNEOANISATIN; 2-HYDROXYNEOANISATIN; SESQUITERPENE; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CHEMICAL STRUCTURE; CONTROLLED STUDY; CONVULSION; CYCLIZATION; ELECTRICITY; ISOMER; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; PHARMACOPHORE; RECTUM TEMPERATURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; CONFORMATION; PLANT;

ANIMALS; CONVULSANTS; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUROTOXINS; PLANTS, TOXIC; SESQUITERPENES; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033233246     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00240-0     Document Type: Article

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