B-cell tumorigenesis in mice carrying a yeast artificial chromosome- based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Eμ)

Cancer Research

Volumn 59, Issue 21, 1999, Pages 5625-5628

  Palomo, Concepción ^a   Zou, Xiangang ^a   Nicholson, Ian C ^a   Bützler, Christoph ^a   Brüggemann, Marianne ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CARCINOGENESIS; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE LOCUS; GENE REARRANGEMENT; GENE TRANSLOCATION; INTRON; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; YEAST ARTIFICIAL CHROMOSOME;

AGE FACTORS; ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CHROMOSOMES, ARTIFICIAL, YEAST; ENHANCER ELEMENTS (GENETICS); FLOW CYTOMETRY; IMMUNOGLOBULIN HEAVY CHAINS; INTRONS; LYMPHOMA, B-CELL; MICE; MICE, INBRED BALB C; MODELS, GENETIC; MUTAGENESIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MYC; TISSUE DISTRIBUTION; TRANSLOCATION, GENETIC; TRANSPLANTATION CHIMERA;

EID: 0033230457     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Rabbitts, T. H. Chromosomal translocations in human cancer. Nature (Lond.), 372: 143-149, 1994.
2. Klein, G. The role of gene dosage and genetic transpositions in carcinogenesis. Nature (Lond.), 294: 313-318, 1981.
3. Stanton, L. W., Watt, R., and Marcu, K. B. Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature (Lond.), 303: 401-406, 1983.
4. Bazin, H., Deckers, C., Beckers, A., and Hereman, J. F. Transplantable immunoglobulin-secreting tumours in rats. I. General features of LOU-Ws1 strain rat immunocytomas and their monoclonal proteins. Int. J. Cancer, 10: 568-580, 1972.
5. Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., and Brinster, R. L. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (Lond.), 318: 533-537, 1985.
6. Schmidt, E. V., Pattengale, P. K., Weir, L., and Leder, P. Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre B-cell lymphoma model. Proc. Natl. Acad. Sci. USA, 85: 6047-6051, 1988.
7. Pettersson, S., Cook, G. P., Brüggemann, M., Williams, G. T., and Neuberger, M. S. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature (Lond.), 344: 165-168, 1990.
8. Jain, V. K., Judde, J. G., Max, E. E., and Magrath, I. T. Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation. J. Immunol., 150: 5418-5428, 1993.
9. Langdon, W. Y., Harris, A. W., Cory S., and Adams, J. M. The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice. Cell, 47: 11-18, 1986.
10. Neuberger, M. S., and Calabi, F. Reciprocal chromosome translocation between c-myc and immunoglobulin γ2b genes. Nature (Lond.), 305: 240-243, 1983.
11. Rabbitts, T. H., Forster, A., Baer, R., and Hamlyn, P. H. Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma. Nature (Lond.), 306: 806-809, 1983.
12. Joos, S., Falk, M. H., Lichter, P., Haluska, F. G., Henglein, B., Lenoir, G. M., and Bornkamm, G. W. Variable breakpoints in Burkitt lymphoma cells with chromosomal t(8;14) translocation separate c-myc and the IgH locus up to several hundred kb. Hum. Mol. Genet., 1: 625-632, 1992.
13. Keath, E. J., Kelekar, A., and Cole, M. D. Transcriptional activation of the translocated c-myc oncogene in mouse plasmacytomas: similar RNA levels in tumor and proliferating normal cells. Cell, 37: 521-528, 1984.
14. Bützler, C., Zou, X., Popov, A. V., and Brüggemann, M. Rapid induction of B-cell lymphomas in mice carrying a human IgH/c-myc YAC. Oncogene, 14: 1383-1388, 1997.
15. Hayday, A. C., Gillies, S. D., Saito, H., Wood, C., Wiman, K., Hayward, W. S., and Tonegawa, S. Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus. Nature (Lond.), 307: 334-340, 1984.
16. Nishiwaki, K., Hayashi, N., Irie, S., Chung, D. H., Harashima, S., and Oshima, Y. Structure of the yeast HIS 5 gene responsive to general control of amino acid biosynthesis. Mol. Gen. Genet., 208: 159-167, 1987.
17. Davies, N. P., Popov, A. V., Zou, X., and Brüggemann, M. Human antibody repertoires in transgenic mice: manipulation and transfer of YACs. In: J. McCafferty, H. R. Hoogenboom, and D. J. Chiswell (eds.), Antibody Engineering: A Practical Approach, pp. 59-76. Oxford: IRL, 1996.
18. Hamlyn, P. H., and Rabbitts, T. H. Translocation joins c-myc and immunoglobulin γI genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene. Nature (Lond.), 304: 135-139, 1983.
19. Hogan, B., Beddington, R., Costantini, F., and Lacy, E. Manipulating the Mouse Embryo. A Laboratory Manual. Cold spring Harbor, NY: Cold Spring Harbor Laboratory, 1994.
20. Zou, X., Xian, J., Popov, A. V., Rosewell, I. R., Müller, M., and Brüggemann, M. Subtle differences in antibody responses and hypermutation of λ light chains in mice with a disrupted κ constant region. Eur. J. Immunol., 25: 2154-2162, 1995.
21. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbour Laboratory, 1989.
22. Gillies, S. D., Morrison, S. L., Oi, V. T., and Tonegawa, S. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell, 33: 717-728, 1983.
23. Biragyn, A., S. Arkins, S., and Kelley, K. W. Riboprobe expression cassettes for measuring IGF-I, β-actin and glyceraldehyde 3-phosphate dehydrogenase transcripts. J. Immunol. Methods, 168: 235-244, 1994.
24. Brüggemann, M., and Neuberger, M. S. Strategies for expressing human antibody repertoires in transgenic mice. Immunol. Today, 17: 391-397, 1996.
25. Jennings, C. D., and Foon, K. A. Recent advances in flow cytometry: application to the diagnosis of hematologic malignancy. Blood, 90: 2863-2892, 1997.
26. Ganick, D. J., and Finlay, J. L. Acute lymphoblastic leukemia with Burkitt cell morphology and cytoplasmic immunoglobulin. Blood, 56: 311-314, 1980.
27. Prokocimer, M., Matzner, Y., Ben-Bassat, H., and Polliack, A. Burkitt's lymphoma presenting as acute leukemia (Burkitt's lymphoma cell leukemia): report of two cases in Israel. Cancer (Phila.), 45: 2884-2889, 1980.
28. Magrath, I. The pathogenesis of Burkitt's lymphoma. Adv. Cancer Res., 55: 133-270, 1990.