Eps1, a novel PDI-related protein involved in ER quality control in yeast

EMBO Journal

Volumn 18, Issue 21, 1999, Pages 5972-5982

  Wang, Qiongqing ^a   Chang, Amy ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

ATPase; ER associated degradation; Molecular chaperone; Plasma membrane; Protein disulfide isomerase

Indexed keywords

CHAPERONE; FUNGAL PROTEIN; PROTEIN DISULFIDE ISOMERASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UBIQUITIN;

ARTICLE; CELL GROWTH; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FUNGAL GENETICS; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; TRAVEL; YEAST;

AMINO ACID SEQUENCE; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASES; CELL MEMBRANE; CLONING, MOLECULAR; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN DISULFIDE-ISOMERASE; PROTON-TRANSLOCATING ATPASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SUPPRESSION, GENETIC; UBIQUITINS;

EID: 0033230434     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.21.5972     Document Type: Article

References (53)

1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman D.J. (1990) Basic local alignment tool. J. Mol. Biol., 215, 403-410.
2. +-ATPase in the open conformation. Nature, 392, 840-843.
3. Benito, B., Moreno, E. and Losario, R. (1991) Half-life of plasma membrane ATPase and its activating system in resting yeast cells. Biochim. Biophys. Acta, 1063, 265-268.
4. Boeke, J.D., Trueheart, J., Natsoulis, G. and Fink, G.R. (1987) 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol., 154, 164-175.
5. Brodsky, J.L. and McCracken, A.A. (1997) ER-associated and proteasome-mediated protein degradation: how two topologically restricted events came together. Trends Cell Biol., 7, 151-156.
6. Brodsky, J.L., Werner, E.D., Dubas, M.E., Goeckeler, J.L., Kruse, K.B. and McCracken, A.A. (1999) The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct. J. Biol. Chem., 274, 3453-3460.
7. Burns, N., Grimwade, B., Ross-Macdonald, P.B., Choi, E.-Y., Finberg, K., Roeder, G.S. and Snyder, M. (1994) Large-scale analysis of gene expression, protein localization and gene disruption in Saccharomyces cerevisiae. Genes Dev., 8, 1087-1105.
8. +]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole. J. Cell Biol., 128, 39-49.
9. +]ATPase involves phosphorylation during intracellular transport. J. Cell Biol., 115, 289-295.
10. Cherry, J.M., Adler, C., Ball, C., Dwight, S., Chervitz, S., Juvik, G., Weng, S. and Botstein, D. (1997) Saccharomyces Genome Database (http:// genome-www.stanford.edu/Saccharomyces).
11. +-ATPase in Saccharomyces cerevisiae. Yeast, 12, 907-916.
12. +-ATPase. Role in protein folding and biogenesis. J. Biol. Chem., 273, 21744-21751.
13. Doering, T.L. and Schekman, R. (1996) GPI anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COPII vesicles. EMBO J., 15, 182-191.
14. Ferrari, D.M. and Soling, H.-D. (1999) The protein disulphide-isomerase family: unraveling a string of folds. Biochem. J., 339, 1-10.
15. Gething, M.-J. and Sambrook, J. (1992) Protein folding in the cell. Nature, 355, 33-45.
16. Gunther, R., Brauer, C., Janetzky, J., Forster, H.-H., Ehbrecht, E.-M., Lehle, L. and Kuntzel, H. (1991) The Saccharomyces cerevisiae TRG1 gene is essential for growth and encodes a lumenal endoplasmic reticulum glycoprotein involved in the maturation of vacuolar carboxypeptidase. J. Biol. Chem., 266, 24557-24563.
17. Hammond, C. and Helenius, A. (1995) Quality control in the secretory pathway. Curr. Opin. Cell Biol., 7, 523-529.
18. Hampton, R.Y., Gardner, R.G. and Rine, J. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol. Biol. Cell, 7, 2029-2044.
19. +-ATPase gene of Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 91, 10531-10535.
20. Higgins, D.G., Bleasby, A.J. and Fuchs, R. (1992) CLUSTAL V: improved software for multiple sequence alignment. Comp. Appl. Biosci., 8, 189-191.
21. Horvath, A., Sutterlin, C., Manning-Krieg, U., Movva, N.R. and Riezman, H. (1994) Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast. EMBO J., 13, 3687-3695.
22. Jackson, M.R., Nilsson, T. and Peterson, P.A. (1990) Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO J., 9, 3153-3162.
23. Jenness, D.D., Li, Y., Tipper, C. and Spatrick, P. (1997) Elimination of defective α-factor pheromone receptors. Mol. Cell. Biol., 17, 6236-6245.
24. Knop, M., Finger, A., Braun, T., Hellmuth, K. and Wolf, D.H. (1996) Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J., 15, 753-763.
25. Kopito, R. (1997) ER quality control: the cytoplasmic connection. Cell, 88, 427-430.
26. Kunkel, T.A., Roberts, J.D. and Zakour, R.A. (1987) Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol., 154, 508-519.
27. LaMantia, M., Miura, H., Tachikawa, H., Kaplan, A., Lennarz, W.J. and Mizunaga, T. (1991) Glycosylation site binding protein and protein disulfide isomerase are identical and essential for cell viability in yeast. Proc. Natl Acad Sci. USA, 88, 4453-4457.
28. Ljungdahl, P.O., Gimeno, C.J., Styles, C.A. and Fink, G.R. (1992) SHR3: a novel component of the secretory pathway specifically required for localization of amino acid permeases. Cell, 71, 463-478.
29. Loayza, D., Tam, A., Schmidt, W.K. and Michaelis, S. (1998) Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae. Mol. Biol. Cell, 9, 2767-2784.
30. Luz, J.M. and Lennarz, W.J. (1996) Protein disulfide isomerase: a multifunctional protein of the endoplasmic reticulum. EXS, 77, 97-117.
31. +-ATPase gene (PMA1). Genetics, 150, 11-19.
32. McCracken, A.A., Karpichev, I.V., Ernaga, J.E., Werner, E.D., Dillin, A.G. and Courchesne, W.E. (1996) Yeast mutants deficient in ER-associated degradation of the Z variant of α-1-protease inhibitor. Genetics, 144, 1355-1362.
33. Mumberg, D., Muller, R. and Funk, M. (1994) Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res., 22, 5767-5768.
34. +]ATPase in secretory vesicles: a new strategy for directed mutagenesis. J. Biol. Chem., 266, 7940-7949.
35. +-ATPase disrupt protein folding and biogenesis. J. Biol. Chem., 273, 7338-7344.
36. +-ATPase; structural and functional role of cysteine residues. J. Biol. Chem., 270, 28535-28540.
37. Plemper, R.K., Bohmler, S., Bordallo, J., Sommer, T. and Wolf, D. (1997) Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation. Nature, 388, 891-895.
38. Roberg, K. Crotwell, J.M., Espenshade, P., Gimeno, R. and Kaiser, C.A. (1999) LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum. J. Cell Biol., 145, 659-672.
39. Rose, M.D., Misra, L.M. and Vogel, J.P. (1989) KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene. Cell, 57, 1211-1221.
40. Rose, M.D., Winston, F. and Hieter, P. (1990) Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 198.
41. Schandel, K.A. and Jenness, D.D. (1994) Direct evidence for ligand-induced internalization of the yeast α-factor pheromone receptor. Mol. Cell. Biol., 14, 7245-7255.
42. Semenza, J.C., Hardwick, K.G., Dean, N. and Pelham, H.R. (1990) ERD2, a yeast gene required for the receptor-mediated retrieval of lumenal ER proteins from the secretory pathway. Cell, 61, 1349-1357.
43. Serrano, R. (1989) Structure and function of plasma membrane ATPase. Annu. Rev. Plant Physiol., 40, 61-94.
44. Sherman, F.,. Hicks, J.B. and Fink, G.R. (1986) Methods in Yeast Genetics: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 523-585.
45. Sikorski, R.S. and Hieter, P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics, 122, 19-27.
46. Sommer, T. and Wolf, D.H. (1997) Endoplasmic reticulum degradation: reverse protein flow of no return. FASEB J., 11, 1227-1233.
47. Steck, T.L. and Yu, J. (1973) Selective solubilization of proteins from red blood cell membranes by protein perturbants. J. Supramol. Struct., 1, 220-232.
48. Stevens, T., Esmon, B. and Schekman, R. (1982) Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole. Cell, 30, 439-448.
49. Sutterlin, C., Doering, T.L., Schimmoller, F., Schroder, S. and Riezman, H. (1997) Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. J. Cell Sci., 110, 2703-2714.
50. Tachibana, C. and Stevens, T.H. (1992) The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase. Mol. Cell. Biol., 12, 4601-4611.
51. Tachikawa, H., Funahashi, W., Takeuchi, Y., Nakanishi, H., Nishihara, R., Katoh, S., Gao, X., Mizunaga, J. and Fujimoto, D. (1997) Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Biochem. Biophys. Res. Commun., 239, 710-714.
52. Tachikawa, H., Takeuchi, Y., Funahashi, W., Miura, T., Gao, X., Fujimoto, D., Mizunaga, T. and Onodera, K. (1995) Isolation and characterization of a yeast gene, MPD1, the overexpression of which suppresses inviability caused by protein disulfide isomerase depletion. FEBS Lett.. 369, 212-216.
53. Wang, C.-C. and Tsou, C.-L. (1998) Enzymes as chaperones and chaperones as enzymes. FEBS Lett., 425, 382-384.