Selective inhibition of low affinity IgE receptor (CD23) processing: P1' bicyclomethyl substituents

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 21, 1999, Pages 3165-3170

  Bailey, Stuart ^a,b   Bolognese, Brian ^c   Faller, Andrew ^c   Louis Flamberg, Pearl ^c   MacPherson, David T ^c   Mayer, Ruth J ^c   Marshall, Lisa A ^c   Milner, Peter H ^c   Mistry, Jayshree ^c   Smith, Dav́id G ^c   Ward, John G ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UCB PHARMA   (Belgium)

^c NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLO COMPOUND; COLLAGENASE; ENZYME INHIBITOR; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; IMMUNOGLOBULIN E RECEPTOR; METALLOPROTEINASE; METHYL GROUP; STROMELYSIN;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; INHIBITION KINETICS; STRUCTURE ACTIVITY RELATION;

BICYCLO COMPOUNDS; COLLAGENASES; ENZYME INHIBITORS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MOLECULAR STRUCTURE; RECEPTORS, IGE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033229871     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00552-1     Document Type: Article

References (8)

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2. See Conrad, D. H. Ann. Rev. Immunol. 1990, 8, 623.
3. Bailey, S.; Bolognese, B.; Buckle, D. R.; Faller, A.; Jackson, S.; McCord, M.; Mayer, R. J.; Marshall, L. A.; Smith, D.G. Bioorg. Med. Chem. Letters 1998, 8, 23.
4. Bailey, S.; Bolognese, B.; Buckle, D. R.; Faller, A.; Jackson, S.; McCord, M.; Mayer, R. J.; Marshall, L. A.; Smith, D.G. Bioorg. Med. Chem. Letters 1998, 8, 29.
5. Seebach, D.; Aebi, J.; Wasmuth, D. Org. Synth. Coll. Vol. VII, 153
6. Seebach, D.; Wasmuth, D. Helv. Chim. Acta 1980, 63, 197.
7. Beckett, R.P.; Davidson, A.H.; Drummond, A.H.; Huxley, P.; Whittaker, M. Drug Disc. Today 1996, 1, 16.
8. For assay methodology see Marolewski, A.E.; Buckle, D.R.; Christie, G.; Earnshaw, D.L.; Flamberg, P.L.; Marshall, L.A.; Smith, D.G.; Mayer, R.J. Biochem. J. 1998, 333, 573.