A novel single nucleotide polymorphism and five probable haplotypes in the 5′ flanking region of the IL-6 gene in African-Americans

Genes and Immunity

Volumn 1, Issue 2, 1999, Pages 166-167

  Osiri, M ^a   McNicholl, J ^b   Moreland, L W ^a   Louis Bridges Jr , S ^a  

^a The University of Alabama at Birmingham   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

African American; IL 6; Single nucleotide polymorphism

Indexed keywords

INTERLEUKIN 6;

ARTICLE; GENETICS; HAPLOTYPE; HUMAN; NEGRO; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

AFRICAN CONTINENTAL ANCESTRY GROUP; HAPLOTYPES; HUMANS; INTERLEUKIN-6; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); UNITED STATES;

EID: 0033224551     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363652     Document Type: Article

References (4)

1. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med 1998; 128: 127-137.
2. Faulds G, Fishman D, Woo P, Humphries S. Novel Fokl polymorphism in the 5′ flanking region of the human IL-6 gene. Genbank Accession No. AF048692, March 16, 1998.
3. Fishman D, Faulds G, Jeffery R et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369-1376.
4. Olomolaiye OO, Wood NAP, Bidwell JL. A novel NlaIII polymorphism in the human IL-6 promoter. Eur J Immunogenet 1997; 25: 267.