Duration of Antibiotic Prophylaxis in High-Risk Patients with Penetrating Abdominal Trauma: A Prospective Randomized Trial

Journal of Gastrointestinal Surgery

Volumn 3, Issue 6, 1999, Pages 648-653

  Cornwell III, Edward E ^a,b   Dougherty, William R ^a   Berne, Thomas V ^a   Velmahos, George ^a   Murray, James A ^a   Chahwan, Santiago ^a   Belzberg, Howard ^a   Falabella, Andres ^a   Morales, Irma R ^a   Asensio, Juan ^a   Demetriades, Demetrios ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Abdominal trauma; Antibiotic prophylaxis; Penetrating trauma

Indexed keywords

CEFOXITIN; CEPHAMYCIN DERIVATIVE;

ABDOMINAL INJURY; ADULT; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BLOOD TRANSFUSION; CLINICAL TRIAL; COLON; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ADMINISTRATION; FEMALE; GUNSHOT INJURY; HUMAN; INJURY; INJURY SCALE; MALE; MICROBIOLOGY; PENETRATING TRAUMA; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TIME; WOUND INFECTION;

ABDOMINAL INJURIES; ADULT; ANTIBIOTIC PROPHYLAXIS; BLOOD TRANSFUSION; CEFOXITIN; CEPHAMYCINS; COLON; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INJURY SEVERITY SCORE; MALE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; TIME FACTORS; WOUND INFECTION; WOUNDS, GUNSHOT; WOUNDS, PENETRATING;

EID: 0033220456     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1091-255X(99)80088-2     Document Type: Article

References (17)

1. Ericsson CD, Fischer RP, Rowlands BJ, Hunt C, Miller-Crotchett P, Reed L II. Prophylactic antibiotics in trauma: The hazards of underdosing. J Trauma 1989;29:1356-1361.
2. Dellinger EP. Antibiotic prophylaxis in trauma: Penetrating abdominal injuries and open fracture. Rev Infect Dis 1991; 13(Suppl 10):S847-857.
3. Oreskovich MR, Dellinger EP, Lennard ES, Wertz M, Carrico CJ, Minshew BH. Duration of preventive antibiotic administration for penetrating abdominal trauma. Arch Surg 1982;117:200-205.
4. Dellinger EP, Wertz MJ, Lennard ES, Oreskovich MR. Efficacy of short-course antibiotic prophylaxis after penetrating intestinal injury. Arch Surg 1986;121:23-30.
5. Fabian TC, Croce MA, Payne LW, Minard G, Pritchard FE, Kudsk KA. Duration of antibiotic therapy for penetrating abdominal trauma: A prospective trial. Surgery 1992;112:788-795.
6. Nichols RL, Smith JW, Klein DB, et al. Risk of infection after penetrating abdominal trauma, N Engl J Med 1984;311:1065-1070.
7. Demetriades D, Lakhoo M, Pezikis A, Charalambides D, Pantanowitz D, Sofianos C. Short-course antibiotic prophylaxis in penetrating abdominal injuries: Ceftriaxone versus cefoxitin. Injury 1991;22:20-24.
8. Nelken N, Lewis F. The influence of injury severity on complication rates after primary closure or colostomy for penetrating colon trauma. Ann Surg 1989;209:439-447.
9. Nichols RL, Smith JW, Robertson GD, et al. Prospective alterations in therapy for penetrating abdominal trauma. Arch Surg 1993;128:55-64.
10. Rowlands BJ, Ericsson CD, Fischer RP. Penetrating abdominal trauma: The use of operative findings to determine length of antibiotic therapy. J Trauma 1987;27:250-255.
11. Moore EE, Dunn EL, Moore JB, Thompson JS. Penetrating abdominal trauma index. J Trauma 1981;21:439-445.
12. Moore FA, Moore EE, Sauaia A. Blood transfusion: An independent risk factor for postinjury multiple organ failure. Arch Surg 1997;132:620-625.
13. Hadjiminas D, Cheadle WG, Spain DA, et al. Antibiotic overkill of trauma victims? Am J Surg 1994;168:288-290.
14. Steinberg S, Salomone J, Flint L, Lynch M, Nichols R. Practicing what we preach: Do antibiotic (ATB) use patterns alter the risk of nosocomial infection in surgical intensive care unit (SICU) patients? Abstract presented at the Surgical Infection Society, Pittsburgh, Pa., May 2, 1997.
15. Eshraghi N, Mullins RJ, Mayberry JC, et al. Surveyed opinion of American trauma surgeons in management of colon injuries. Poster presented at the Fifty-Seventh Annual Meeting of the American Association for the Surgery of Trauma, Waikoloa, Hawaii, September 24, 1997.
16. Namias N, Harvill S, Ball S, McKenney MG, et al. Cost and morbidity associated with antibiotic prophylaxis in the ICU. J Am Coll Surg 1999;188:225-230.
17. Polk HC Jr, Cheadle WG, Livingston DH, et al. A randomized prospective clinical trial to determine the efficacy of interferon-gamma in severely injured patients. Am J Surg 1992;163:191-196.