Genetic responses against nitric oxide toxicity

Brazilian Journal of Medical and Biological Research

Volumn 32, Issue 11, 1999, Pages 1417-1427

  Demple, B ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Heme oxygenase 1; Oxidative stress; RNA stability; SoxR protein; Transcriptional regulation

Indexed keywords

MAMMALIA; MURINAE;

BACTERIAL PROTEIN; HEME OXYGENASE; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MESSENGER RNA; NITRIC OXIDE; SOXR PROTEIN, BACTERIA; TRANSCRIPTION FACTOR;

ANIMAL; CELL LINE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ENZYME INDUCTION; ENZYMOLOGY; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; HELA CELL; HUMAN; METABOLISM; MOTONEURON; NORTHERN BLOTTING; OXIDATIVE STRESS; REVIEW; TIME;

ANIMALS; BACTERIAL PROTEINS; BLOTTING, NORTHERN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ENZYME INDUCTION; FIBROBLASTS; GENE EXPRESSION; HELA CELLS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; MEMBRANE PROTEINS; MOTOR NEURONS; NITRIC OXIDE; OXIDATIVE STRESS; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033220348     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1999001100013     Document Type: Article

References (64)

1. Marletta MA (1993). Nitric oxide synthase: function and mechanism. Advances in Experimental Medicine and Biology, 338: 281-284.
2. Crane BR, Arvai AS, Ghosh DK, Wu C, Getzoff ED, Stuehr DJ & Tainer JA (1998). Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science, 279: 2121-2126.
3. MacMicking J, Xie QW & Nathan C (1997). Nitric oxide and macrophage function. Annual Review of Immunology, 15: 323-350.
4. Hibbs JBJ, Taintor RB, Vavrin Z & Rachlin EM (1988). Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochemical and Biophysical Research Communications, 157: 87-94.
5. Nunoshiba T, deRojas-Walker T, Wishnok JS, Tannenbaum SR & Demple B (1993). Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages. Proceedings of the National Academy of Sciences, USA, 90: 9993-9997.
6. Nunoshiba T, deRojas-Walker T, Tannenbaum SR & Demple B (1995). Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages Infection and Immunity, 63: 794-798.
7. Kooy NW, Lewis SJ, Royall JA, Ye YZ, Kelly DR & Beckman JS (1997). Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite. Critical Care Medicine, 25: 812-819.
8. Drapier J-C (1997). Interplay between NO and (Fe-S) clusters: Relevance to biological systems. Methods, 11: 319-329.
9. Kwon NS, Stuehr DJ & Nathan CF (1991). Inhibition of tumor cell ribonucleotide reductase by macrophage-denved nitric oxide. Journal of Experimental Medicine, 174: 761-767.
10. Tamir S, Burney S & Tannenbaum SR (1996). DNA damage by nitric oxide. Chemical Research in Toxicology, 9: 821-827.
11. Schmidt HHHW & Walter U (1994). NO at work. Cell, 78: 919-925.
12. Hobbs AJ & Ignarro LJ (1996). Nitric oxide-cyclic GMP signal transduction system. Methods in Enzymology, 269: 134-148.
13. Stamler JS, Jia L, Eu JP, Mcmahon TJ, Demchenko IT, Bonaventura J, Gernert K & Piantadosi CA (1997). Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science, 276: 2034-2037.
14. Brenman JE & Bredt DS (1996). Nitric oxide signaling in the nervous system. Methods in Enzymology, 269: 119-129.
15. O'Dell TJ, Huang PL, Dawson TM, Dinerman JL, Snyder SH, Kandel ER & Fishman MC (1994). Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science, 265: 542-546.
16. Son H, Hawkins RD, Martin K, Kiebler M, Huang PL, Fishman MC & Kandel ER (1996). Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. Cell, 87: 1015-1023.
17. Geller DA, Nussler AK, Di Silvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL & Billia TR (1993). Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proceedings of the National Academy of Sciences, USA, 90: 522-526.
18. Gilbert RS & Herschman HR (1993). "Macrophage" nitric oxide synthase is a glucocorticoid-inhibitable primary response gene in 3T3 cells. Journal of Cellular Physiology, 157: 128-132.
19. Kawase M, Kinouchi H, Kato I, Akabane A, Kondo T, Arai S, Fujimura M, Okamoto H & Yoshimoto T (1996). Inducible nitric oxide synthase following hypoxia in rat cultured glial cells. Brain Research, 738: 319-322.
20. Kitamura Y, Furukawa M, Matsuoka Y, Tooyama I, Kimura H, Nomura Y & Taniguchi T (1998). In vitro and in vivo induction of heme oxygenase-1 in rat glial cells - Possible involvement of nitric oxide production from inducible nitric oxide synthase. Glia, 22: 138-148.
21. Adamson DC, Wildemann B, Sasaki M, Glass JD, McArthur JC, Christov VI, Dawson TM & Dawson VL (1996). Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science, 274: 1917-1921.
22. Beckman JS, Chen J, Ischiropoulos H & Crow JP (1994). Oxidative chemistry of peroxynitrite. Methods in Enzymology, 233: 229-240.
23. Luperchio S, Tamir S & Tannenbaum SR (1996). NO-induced oxidative stress and glutathione metabolism in rodent and human cells. Free Radical Biology and Medicine, 21: 513-519.
24. Bolan̄os JP, Heales SJR, Peuchen S, Barker JE, Land JM & Clark JB (1996). Nitric oxide-mediated mitochondrial damage - a potential neuroprotective role for glutathione. Free Radical Biology and Medicine, 21: 995-1001.
25. Demple B & Harrison L (1994). Repair of oxidative damage to DNA: enzymology and biology. Annual Review of Biochemistry, 63: 915-948.
26. Ames BN, Shigenaga MK & Hagen TM (1993). Oxidants, antioxidants and the degenerative diseases of aging. Proceedings of the National Academy of Sciences, USA, 90: 7915-7922.
27. Melov S, Schneider JA, Day BJ, Hinerfeld D, Coskun P, Mirra SS, Crapo JD & Wallace DC (1998). A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nature Genetics, 18: 159-163.
28. Esumi H & Tannenbaum SR (1994). U.S.-Japan Cooperative Cancer Research Program: seminar on nitric oxide synthase and carcinogenesis. Cancer Research, 54: 297-301.
29. Ohshima H & Bartsch H (1994). Chronic infectoins and inflammatory processes as cancer risk factors - Possible role of nitric oxide in carcinogenesis. Mutation Research, 305: 253-264.
30. Ambs S, Hussain SP & Harris CC (1997). Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression (Review). FASEB Journal, 11: 443-448.
31. Tamir S & Tannenbaum SR (1996). The role of nitric oxide (NO) in the carcinogenic process. Biochimica et Biophysica Acta, 1288: F31-F36.
32. Wink DA, Vodovotz Y, Laval J, Laval F, Dewhirst MW & Mitchell JB (1998). The multifaceted roles of nitric oxide in cancer. Carcinogenesis, 19: 711-721.
33. Hartsfield CL, Alam J, Cook JL & Choi AM (1997). Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide. American Journal of Physiology, 273: L980-L988.
34. Takahashi K, Hara E, Ogawa K, Kimura D, Fujita H & Shibahara S (1997). Possible implications of the inductions of human heme oxygenase-1 by nitric oxide donors. Journal of Biochemistry, 121: 1162-1168.
35. Marquis JC & Demple B (1998). Complex genetic response of human cells to sublethal levels of pure nitric oxide. Cancer Research, 58: 3435-3440.
36. Bishop A, Marquis JC, Cashman NR & Demple B (1999). Adaptive resistance to nitric oxide in motor neurons. Free Radical Biology and Medicine, 26: 978-986.
37. Greenberg JT, Monach P, Chou JH, Josephy PD & Demple B (1990). Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli. Proceedings of the National Academy of Sciences, USA, 87: 6181-6185.
38. Tsaneva IR & Weiss B (1990). soxR, a locus governing a superoxide response regulon in Escherichia coli K-12. Journal of Bacteriology, 172: 4197-4205
39. Hidalgo E, Ding H & Demple B (1997). Redox signal transduction via iron-sulfur clusters in the soxR transcription factor. Trends in Biochemical Sciences, 22: 207-210.
40. Hidalgo E & Demple B (1994). An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein. EMBO Journal, 13: 138-146.
41. Gaudu P & Weiss B (1996). SoxR, a (2Fe-2S) transcription factor, is active only in its oxidized form. Proceedings of the National Academy of Sciences, USA, 93: 10094-10098.
42. Li Z & Demple B (1994). SoxS, an activator of superoxide stress genes in E. coli. Purification and interaction with DNA. Journal of Biological Chemistry, 269: 18371-18377.
43. Hidalgo E & Demple B (1996). Adaptive responses to oxidative stress: the soxRs and oxyR regulons. In: Lin ECC & Lynch AS (Editors), Regulation of Gene Expression in Escherichia coli. R.G. Landes, Austin, TX, 435-452.
44. Chou JH, Greenberg JT & Demple B (1993). Posttranscriptional repression of E. coli OmpF protein in response to redox stress: positive control of the micF antisense RNA by the soxRS locus. Journal of Bacteriology, 175: 1026-1031.
45. Ma D, Alberti M, Lynch C, Nikaido H & Hearst JE (1996). The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Molecular Microbiology, 19: 101-112.
46. Ariza RR, Cohen SP, Bachhawat N, Levy SB & Demple B (1994). Repressor mutations in the marPAB operon that activate oxidative stress genes and multiple antibiotic resistance in E. coli. Journal of Bacteriology, 176: 143-148.
47. Ariza RR, Li Z, Ringstad N & Demple B (1995). Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob protein. Journal of Bacteriology, 177: 1655-1661.
48. Greenberg JT, Chou JH, Monach PA & Demple B (1991). Activation of oxidative stress genes by mutations at the soxQ/ cfxB/marA locus of Escherichia coli. Journal of Bacteriology, 173: 4433-4439.
49. Tamir S, Lewis RS, de Rojas Walker T, Deen WM, Wishnok JS & Tannenbaum SR (1993). The influence of delivery rate on the chemistry and biological effects of nitric oxide. Chemical Research in Toxicology, 6: 895-899.
50. Tamir S, deRojas-Walker T, Gal A, Weller AH, Li X, Fox JG, Wogan GN & Tannenbaum SR (1995). Nitric oxide production in relation to spontaneous B-cell lymphoma and myositis in SJL mice. Cancer Research, 55: 4391-4397.
51. Tyrrell RM (1997). Approaches to define pathways of redox regulation of a eukaryotic gene: the heme oxygenase 1 example. Methods, 11: 313-318.
52. Kim Y-M, Bergonia HA, Müller C, Pitt BR, Watkins WD & Lancaster JRJ (1995). Loss and degradation of enzyme-bound heme induced by cellular nitric oxide synthesis. Journal of Biological Chemistry, 270: 5710-5713.
53. Takahashi K, Hara E, Suzuki H, Sasano H & Shibahara S (1996). Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors. Journal of Neurochemistry, 67: 482-489.
54. Motterlini R, Foresti R, Intaglietta M & Winslow RM (1996). NO-mediated activation of herne oxygenase: endogenous cytoprotection against oxidative stress to endothelium. American Journal of Physiology, 270: H107-H114.
55. Cashman NR, Durham HD, Blusztajn JK, Oda K, Tabira T, Shaw IT, Dahrouge S & Antel JP (1992). Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Developmental Dynamics, 194: 209-221.
56. Durham HD, Dahrouge S & Cashman NR (1993). Evaluation of the spinal cord neuron X neuroblastoma hybrid cell line NSC-34 as a model for neurotoxicity testing. Neurotoxicology, 14: 387-395.
57. Matsumoto A, Yoshino H, Yuki N, Hara Y, Cashman NR, Handa S & Miyatake T (1995). Ganglioside characterization of a cell line displaying motor neuron-like phenotype: GM2 as a possible major ganglioside in motor neurons. Journal of the Neurological Sciences, 131: 111-118.
58. Escourolle R & Poirier J (Editors) (1978). Manual of Basic Neuropathology. 2nd edn. W.B. Saunders, Philadelphia, 1-17.
59. Kim Y-M, Bergonia H & Lancaster JRJ (1995). Nitrogen oxide-induced autoprotection in isolated rat hepatocytes. FEBS Letters, 374: 228-232.
60. Polte T, Oberle S & Schroder H (1997). The nitric oxide donor Sin-1 protects endothelial cells from tumor necrosis factor-alpha mediated cytotoxicity - Possible role for cyclic GMP and heme oxygenase. Journal of Molecular and Cellular Cardiology, 29: 3305-3310.
61. Nunoshiba T & Demple B (1993). Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide. Cancer Research, 53: 3250-3252.
62. Pellat C, Henry Y & Drapier JC (1990). IFN-gamma-activated macrophages: detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and non-heme iron proteins. Biochemical and Biophysical Research Communications, 166: 119-125.
63. Kennedy MC, Antholine WE & Beinert H (1997). An EPR investigation of the products of the reaction of cytosolic and mitochondrial aconitases with nitric oxide. Journal of Biological Chemistry, 272: 20340-20347.
64. Demple B (1999). Radical ideas: Genetic responses to oxidative stress. Clinical and Experimental Pharmacology and Physiology, 26: 64-68.