Expression pattern of chemoresistance-related genes in human malignant brain tumors: A working knowledge for proper selection of anticancer drugs

Japanese Journal of Clinical Oncology

Volumn 29, Issue 11, 1999, Pages 527-534

  Nagane, Motoo ^a,c   Asai, Akio ^b,d   Shibui, Soichiro ^a   Oyama, Hiroshi ^a   Nomura, Kazuhiro ^a   Kuchino, Yoshiyuki ^c,d  

^a NATIONAL CANCER CENTER HOSPITAL   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Brain tumors; Chemoresistance; mdr1; MGMT

Indexed keywords

ANTINEOPLASTIC AGENT; CD9 ANTIGEN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; NIMUSTINE;

ARTICLE; BRAIN TUMOR; CELL CULTURE; DRUG EFFECT; GENE; GENETICS; GLIOMA; HUMAN; PATHOLOGY;

ANTIGENS, CD; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GENES, MDR; GLIOMA; HUMANS; MEMBRANE GLYCOPROTEINS; NIMUSTINE; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0033218997     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: 10.1093/jjco/29.11.527     Document Type: Article

References (53)

1. Greene GM, Hitchon PW, Schelper RL, Yuh W, Dyste GN. Diagnostic yield in CT-guided stereotactic biopsy of gliomas. J Neurosurg 1989;71:494-7.
2. The Committee of Brain Tumor Registry of Japan. The Seventh Report from the Brain Tumor Registry of Japan. Neurol Med Chir (Tokyo) 1992;32:385-547.
3. Greig NH. Optimizing drug delivery to brain tumors. Cancer Treat Rev 1987;14:1-28.
4. Morrow CS, Cowan KH. Glutathione S-transferase and drug resistance. Cancer Cells 1990;2:15-22.
5. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992;58:1650-4.
6. Kelley SL, Basu A, Teicher BA, Hacker MP, Hamer DH, Lazo JS. Overexpression of metallothionein confers resistance to anticancer drugs. Science 1988;241:1813-5.
7. Lehmann AR, Hoeijmakers JHJ, van Zeeland AA, Backendorf CMP, Bridges BA, Collins A, et al. Workshop on DNA repair. Mutat Res 1992;273:1-28.
8. Pan SS, Akman SA, Forrest GL, Hipsher C, Johnson R. The role of NAD (P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells. Cancer Chemother Pharmacol 1992;31:23-31.
9. Takano H, Kohno K, Ono M, Uchida Y, Kuwano M. Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells. Cancer Res 1991;51:3951-7.
10. Tsuruo T. Mechanism of multidrug resistance and implications for therapy. Jpn J Cancer Res 1988;79:285-96.
11. van Maanen JMS, de Vries J, Pappie D, van den Akker E, Lafleur VM, Retel J, van der Greef J, et al. Cytochrome P-450-mediated O-demethylation: a route in the metabolic activation of etoposide (VP-16-213). Cancer Res 1987;47:4658-62.
12. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 1990;50:6119-29.
13. Basu A, Lazo JS. A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs. Toxicol Lett 1990;50:123-35.
14. Hara A, Sakai N, Yamada H, Niikawa S, Yoshimi N, Mori H. Localization of the placental form of glutathione S-transferase messenger ribonucleic acid in human glioma cell lines. Neurosurgery 1993;33:100-4.
15. 6-Methylguanine methyltransferase activity and sensitivity of Japanese tumor cell strains to 1- (4-amino-2-methyl-5-pyrimidinyl)methyl-3- (2-chloroethyl)-3-nitrosourea hydrochloride. Jpn J Cancer Res (Gann) 1987;78:1207-15.
16. Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986;47:381-9.
17. Kartner N, Riordan JR, Ling V. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 1983;221:1285-8.
18. Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of the multidrug resistance gene product (p-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 1990;38:1277-87.
19. Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994;77:491-502.
20. Broxterman HJ, Giaccone G, Lankelma J. Multidrug resistance proteins and other drug transport-related resistance to natural product agents. Curr Opin Oncol 1995;7:532-40.
21. Zaman GJR, Flens MJ, van Leusden MR, de Haas M, Mülder HS, Lankelma J, et al. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci USA 1994;91:8822-6.
22. Abe T, Hasegawa S, Taniguchi K, Yokomizo A, Kuwano T, Ono M, et al. Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells. Int J Cancer 1994;58:860-4.
23. Kasahara K, Fujiwara Y, Nishio K, Ohmori T, Sugimoto Y, Komiya K, et al. Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin. Cancer Res 1991;51:3237-47.
24. Yang LY, Trujillo JM, Siciliano MJ, Kido Y, Siddik ZH, Su YZ. Distinct P-glycoprotein expression in two subclones simultaneously selected from a human colon carcinoma cell line by cis-diamminedichloroplatinum (II). Int J Cancer 1993;53:478-85.
25. Fujiwara Y, Sugimoto Y, Kasahara K, Bungo M, Yamakido M, Tew KD, Saijo N. Determinants of drug response in a cisplatin-resistant human lung cancer cell line. Jpn J Cancer Res 1990;81:527-35.
26. Kagi JHR, Kojima Y. Chemistry and biochemistry of metallothionein. Exs 1987;52:25-61.
27. Teicher BA, Holden SA, Kelley MJ, Shea TC, Cucchi CA, Rosowsky A, et al. Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum (II). Cancer Res 1987;47:388-93.
28. Mousseau M, Chauvin C, Nissou MF, Chaffanet M, Plantaz D, Pasquier B, et al. A study of the expression of four chemoresistance-related genes in human primary and metastatic brain tumours. Eur J Cancer 1993;29A:753-9.
29. Gudkov AV, Kazarov AR, Thimmapaya R, Axenovich SA, Mazo IA, Roninson IB. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci USA 1994;91:3744-8.
30. Rutka JT, Giblin JR, Dougherty DY, Liu HC, McCulloch JR, Bell C, Stern RS, Wilson CB, Rosenblum ML. Establishment and characterization of five cell lines derived from human malignant gliomas. Acta Neuropathol (Berl) 1987;75:92-103.
31. Westermark B, Ponten J, Hugosson R. Determinants for the establishment of permanent tissue culture lines from human gliomas. Acta Pathol Microbiol Scand [A] 1973;81:791-805.
32. 6-methylguanine-DNA methyltransferase and chloroethyl-nitrosourea resistance of human brain tumors. Jpn J Clin Oncol 1992;22:143-9.
33. Nagane M, Levitzki A, Gazit A, Cavenee WK, Huang HJS. Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci USA 1998;95:5724-9.
34. 6-methylguanine methyltransferase. No Shinkei Geka Journal 1992;1:170-2 (in Japanese).
35. Goldstein LJ, Galski H, Fojo A, Willingham M, Lai S, Gazdar A, Pirker R, Green A, Crist W, Brodeur GM, Lieber M, Cossman J, Gottesman MM, Pastan I. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 1989;81:116-124.
36. 6-Methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics. Cancer Res 1998;58:1068-73.
37. Glass J. The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy. J Neurosurg 1992;76:741-5.
38. Toth K, Vaughan MM, Peress NS, Slocum HK, Rustum YM. MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors. Am J Pathol 1996;149:853-8.
39. von Bossanyi P, Diete S, Dietzmann K, Warich Kirches M, Kirches E. Immunohistochemical expression of P-glycoprotein and glutathione S-transferases in cerebral gliomas and response to chemotherapy. Acta Neuropathol (Berl) 1997;94:605-11.
40. Zaman GJR, Versantvoort CHM, Smit JJM, Eijdems EWHM, de Haas M, Smith AJ, et al. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res 1993;53:1747-50.
41. Huai-Yun H, Secrest DT, Mark KS, Carney D, Brandquist C, Elmquist WF, et al. Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells. Biochem Biophys Res Commun 1998;243:816-20.
42. Kusuhara H, Suzuki H, Naito M, Tsuruo T, Sugiyama Y. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. J Pharmacol Exp Ther 1998;285:1260-5.
43. Godwin AK, Meister A, O'Dwyer PJ, Huang CS, Hamilton TC, Anderson ME. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci USA 1992;89:3070-4.
44. Hida T, Kuwabara M, Ariyoshi Y, Takahashi T, Sugiura T, Hosoda K, et al. Serum glutathione S-transferase-p level as a tumor marker for non-small cell lung cancer. Potential predictive value in chemotherapeutic response. Cancer 1994;73:1377-82.
45. Nagane M, Shibui S, Oyama H, Asai A, Kuchino Y, Nomura K. Investigation of chemoresistance-related genes mRNA expression for selecting anticancer agents in successful adjuvant chemotherapy for a case of recurrent glioblastoma: a case report. Surg Neurol 1995;44:462-8.
46. Bungo M, Fujiwara Y, Kasahara K, Nakagawa K, Ohe Y, Sasaki Y, et al. Decreased accumulation as a mechanism of resistance to cis-diamminedichloroplatinum (II) in human non-small cell lung cancer cell lines: relation to DNA damage and repair. Cancer Res 1990;50:2549-53.
47. Eastman A, Schulte N. Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum (II). Biochemistry 1988;27:4730-4.
48. Zhen W, Link CJ Jr, O'Connor PM, Reed E, Parker R, Howell SB, et al. Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines. Mol Cell Biol 1992;12:3689-98.
49. Miyashita T, Reed JC. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 1993;81:151-7.
50. 6-benzylguanine in vitro. Carcinogenesis 1993;14:1057-60.
51. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci USA 1990;87:5368-72.
52. Tsuruo T, Hamada H, Sato S, Heike Y. Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies. Jpn J Cancer Res 1989;80:627-31.
53. 6-methylguanine-deoxyribonucleic acid methyltransferase messenger ribonucleic acid for therapy of malignant gliomas. Neurosurgery 1997;41:434-40; discussion 440.