Selective solid-phase iodination of phenolic groups with bis(pyridine)iodonium (I) tetrafluoroborate

Tetrahedron Letters

Volumn 40, Issue 40, 1999, Pages 7279-7282

  Arsequell, Gemma ^a   Espuñ, Gemma ^a   Valencia, Gregorio ^a   Barluenga, José ^b   Carlón, Raquel Pérez ^b   González, José M ^b  

^a DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^b UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Biologically active compounds; Halogenation; Protecting groups; Supported reagents reactions

Indexed keywords

DERMORPHIN; ETHER DERIVATIVE; ORGANOIODINE DERIVATIVE; ORGANOSILICON DERIVATIVE; PHENOL DERIVATIVE;

ARTICLE; IODINATION; PARTIAL DRUG SYNTHESIS; REACTION ANALYSIS; SOLID; STEREOCHEMISTRY;

EID: 0033215052     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01522-1     Document Type: Article

References (24)

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15. 2 at room temperature, for 10 min. In the solid phase, a rink amide resin was chosen because of the simplicity to anchor amino acids to the resin through an amide linkage (standard solid-phase protocols).
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18. 3SiH =95:2.5:2.5).
19. 2.
20. 1H-NMR, thus confirming the observation that protected Tyr residues are unreactive.
21. Identified by comparison with a commercial sample of dermorphin.
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