Expression of proliferating cell nuclear antigen and CD44 variant isoforms in the primary and metastatic sites of nonsmall cell lung carcinoma with intrapulmonary metastases

Cancer

Volumn 86, Issue 7, 1999, Pages 1174-1181

  Fukuse, Tatsuo ^a   Hirata, Toshiki ^a   Naiki, Hironobu ^b   Hitomi, Shigeki ^a   Wada, Hiromi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

CD44 variant isoforms; Intrapulmonary metastases; Nonsmall cell lung carcinoma; Prognosis; Proliferating cell nuclear antigen

Indexed keywords

CYCLINE; HERMES ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; HISTOGENESIS; HUMAN; LUNG METASTASIS; LUNG NON SMALL CELL CANCER; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL;

ADENOCARCINOMA; AGED; ANTIGENS, CD44; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN ISOFORMS; SURVIVAL RATE;

EID: 0033214811     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19991001)86:7<1174::AID-CNCR11>3.0.CO;2-8     Document Type: Article

References (22)

1. American Joint Committee on Cancer. Manual for staging of cancer. 4th ed. Philadelphia: J.B. Lippincott, 1992:115-22.
2. Fukuse T, Hirata T, Tanaka F, Yanagihara K, Hitomi S, Wada H. Prognosis of ipsilateral intrapulmonary metastases in resected nonsmall cell lung cancer. Eur J Cardiothorac Surg 1997;12:218-23.
3. Ichinose Y, Hara N, Ohta M. Synchronous lung cancers defined by deoxyribonucleic acid flow cytometry. J Thorac Cardiovasc Surg 1991;102:418-24.
4. Martini N, Malemed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg 1975;70:606-12.
5. Umehara Y, Kimura T, Yoshida M, Oba N, Harada Y. Comparison of flow cytometric DNA content in primary gastric carcinoma and metastases. J Surg Oncol 1992;50:156-60.
6. Nishizaki T, DeVries S, Chew K, Goodson WH III, Ljung BM, Thor A, et al. Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization. Genes Chromosomes Cancer 1997;19:267-72.
7. Bravo R, Frank R, Blundell PA, MacDonald-Bravo H. Cyclin/ PCNA is the auxiliary protein of DNA polymerase delta. Nature 1987;326:515-7.
8. Kawai T, Suzuki M, Kono S, Shinoyama N, Rokutanda M, Takagi K, et al. Proliferating cell nuclear antigen and Ki-67 in lung carcinoma correlation with DNA flow cytometric analysis. Cancer 1994;74:2468-75.
9. Fontanini G, Macchiarini P, Pepe S, Ruggiero A, Hardin M, Bigini D, et al. The expression of proliferating cell nuclear antigen in paraffin sections of peripheral, node-negative non-small cell lung cancer. Cancer 1992;70:1520-7.
10. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyarulonaste. Cell 1990;61:1303-13.
11. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA 1992;89:12160-4.
12. Güthert U, Hofmann M, Rudy W, Reber S, Zöller M, Haussmann I, et al. A new variant of glycoprotein CD44 confers metastaic potential to rat cell carcinoma cells. Cell 1991;65: 13-24.
13. Kaufmann M, Heider KH, Sinn HP, von Minckwitz G, Ponta H, Herrlich P. CD44 variant exon epitopes in primary breast cancer and length of survival. Lancet 1995;345:615-9.
14. Mayer B, Jauch KW, Günthert U, Figdor CG, Schildberg FW, Funke I, et al. De novo expression of CD44 and survival in gastric cancer. Lancet 1993;342:1019-22.
15. Mulder JW, Kruyt PM, Sewnath M, Oosting J, Seldenrijk CA, Weidema WF, et al. Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. Lancet 1994;344: 1470-2.
16. Hirata T, Fukuse T, Naiki H, Hitomi S, Wada H. Expression of CD44 variant exon 6 in Stage I non-small cell lung carcinoma as a prognostic factor. Cancer Res 1998;58: 1108-10.
17. Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997;111:1710-7.
18. Ebina M, Steinberg SM, Mulshine JL, Linnoila RI. Relationship of p53 overexpression and up-regulation of cell nuclear antigen with the clinical course of non-small cell lung cancer. Cancer Res 1994;54:2496-503.
19. Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA. Relation of neovascularisation to metastasis of non-small cell lung cancer. Lancet 1992;340:145-6.
20. Ishida T, Kaneko S, Akazawa K, Tateishi M, Sugio K, Sugimachi K. Proliferating cell nuclear antigen expression and argyrophilic nuclear organizer regions as factors influencing prognosis of surgically treated lung cancer patients. Cancer Res 1993;53:500-3.
21. Fasano M, Sabatini MT, Wieczorek R, Sidhu G, Goswami S, Jagirdar J. CD44 and its v6 spliced variant in lung tumors. A role in histogenesis? Cancer 1997;80:34-41.
22. Penno MB, August JT, Baylin SB, Mabry M, Linnoila I, Lee VS, et al. Expression of CD44 in human lung tumors. Cancer Res 1994;54:1382-7.