Identification and functional characterization of the ζ-chain dimerization motif for TCR surface expression

Journal of Immunology

Volumn 163, Issue 7, 1999, Pages 3867-3876

  Bolliger, Luca ^a,b   Johansson, Britt ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; GLYCINE; GLYCOPHORIN A; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGRADATION; DIMERIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CONSERVED SEQUENCE; DIMERIZATION; GLYCOPHORIN; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; POINT MUTATION; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL;

EID: 0033214418     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Klausner, R. D., J. Lippincott-Schwarz, and J. S. Bonifacino. 1990. The T cell antigen receptor: insights into organelle biology. Annu. Rev. Cell. Biol. 6:403.
2. Wegener, A. M. K., F. Letourneur, A. Hoeveler, T. Brocker, F. Luton, and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68:83.
3. Reth, M. 1989. Antigen receptor tail clue. Nature 338:383.
4. Letourneur, F., and R. D. Klausner. 1992. Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3ε. Science 255:79.
5. + thymocytes. Immunity 2:391.
6. Hall, C., B. Alarcon, J. Sancho, T. Wileman, and C. Terhost. 1991. Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells. Int. Immunol. 3:359.
7. Manolios, N., J. S. Bonifacino, and R. D. Klausner. 1990. Transmembrane helical interactions and the assembly of the T cell receptor complex. Science 249:274.
8. Cosson, P., S. P. Lankford, J. S. Bonifacino, and R. D. Klausner. 1991. Membrane protein association by potential intramembrane charge pairs. Nature 351: 414.
9. Manolios, N., F. Letourneur, J. S. Bonifacino, and R. D. Klausner. 1991. Pair-wise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor. EMBO J. 10:1643.
10. Bonifacino, J. S., P. Cosson, N. Shah, and R. D. Klausner. 1991. Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum. EMBO J. 10:2783.
11. Rutledge, T., P. Cosson, N. Manolios, J. Bonifacino, and R. D. Klausner. 1992. Transmembrane helical interactions: ζ chain dimerization and functional association with the T cell antigen receptor. EMBO J. 11:3245.
12. Wegener, A. M. K., X. Hou, J. Dietrich, and C. Geisler. 1995. Distinct domains of the CD3γ chain are involved in surface expression and function of the T cell antigen receptor. J. Biol. Chem. 270:4675.
13. Dietrich, J., A. Neisig, X. Hou, A. M. K. Wegener, M. Gajhede, and C. Geisler. 1996. Role of CD3γ in T cell receptor assembly. J. Cell Biol. 132:299.
14. Manolios, N., O. Kemp, and Z. G. Li. 1994. The T cell antigen receptor α and β chains interact via distinct regions with CD3 chains. Eur. J. Immunol. 24:84.
15. Sussman, J., J. S. Bonifacino, J. Lippincott-Schwartz, A. M. Weissman, T. Saito, R. D. Klausner, and J. D. Ashwell. 1988. Failure to synthesize the T cell CD3-ζ chain: Structure and function of a partial T cell receptor complex. Cell 52:85.
16. Johansson, B., E. Palmer, and L. Bolliger. 1999. The extracellular domain of the ζ-chain is essential for TCR function. J. Immunol. 162:878.
17. Romeo, C., and B. Seed. 1991. Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 64:1037.
18. Lanier, L. L., G. Yu, and J. H. Phillips. 1991. Analysis of FcγRIII (CD16) membrane expression and association with CD3ζ and FcεRI-γ by site-directed mutation. J. Immunol. 146:1571.
19. Kurosaki, T., I. Gander, and J. V. Ravetch. 1991. A subunit common to an IgG Fc receptor and the T cell receptor mediates assembly through different interactions. Proc. Natl. Acad. Sci. USA 88:3837.
20. Dietrich, J., and C. Geisler. 1998. T cell receptor ζ allows stable expression of receptors containing the CD3γ leucine-based receptor sorting motif. J. Biol. Chem. 273:26281.
21. Letourneur, F., and B. Malissen. 1989. Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a non-functional α-mRNA of BW5147 origin. Eur. J. Immunol. 19:2269.
22. Bolliger, L., B. Johansson, and E. Palmer. 1997. The short extracellular domain of the T cell receptor ζ chain is involved in assembly and signal transduction. Mol. Immunol. 34:819.
23. Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980.
24. Morgenstern, J. P., and H. Land. 1990. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:3587.
25. Mullen, C. A., M. Kilstrup, and R. M. Blaese. 1992. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc. Natl. Acad. Sci. USA 89:33.
26. Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392.
27. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
28. Meier, T., S. Arni, S. Malarkannan, M. Poincelet, and D. Hoessli. 1992. Immunodetection of biotinylated lymphocyte-surface proteins by enhanced chemiluminescence: a nonradioactive method for cell-surface protein analysis. Anal. Biochem. 204:220.
29. Rozdzial, M. M., R. T. Kubo, S. L. Turner, and T. H. Finkel. 1994. Developmental regulation of the TCR ζ-chain: differential expression and tyrosine phosphorylation of the TCR ζ-chain in resting immature and mature T lymphocytes. J. Immunol. 153:1563.
30. Guex, N. 1996. Swiss-PDBviewer: a new fast and easy to use PDB viewer for Macintosh. Experimentia 52:A26.
31. Sayle, R. A., and W. E. Milner. 1995. RASMOL: biomolecular graphics for all. Trends Biochem. Sci. 20:374.
32. Carson, M. 1991. Ribbons 2.0. J. Appl. Cryst. 24:958.
33. MacKenzie, K. R., J. H. Prestegrad, and D. M. Engelman. 1997. A transmembrane helix dimer: structure and implications. Science 276:131.
34. Gerber, P. R., and K. Muller. 1995. MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry. J. Comput. Aided Mol. Des. 9:251.
35. Lemmon, M. A., J. M. Flanagan, H. R. Treutlein, J. Zhang, and D. M. Engelmean. 1992. Sequence specificity in the dimerization of transmembrane α-helices. Biochemistry 31:12719.
36. Lemmon, M. A., H. R. Treutlein, P. D. Adams, A. T. Brünger, and D. M. Engelman. 1994. A dimerization motif for transmembrane α-helices. Nat. Struct. Biol. 1:157.
37. Mingarro, I., P. Whitley, M. A. Lemmon, and G. VonHeijne. 1996. Ala-scanning mutagenesis of the glycophorin A transmembrane helix: a rapid way to map helix-helix interactions in integral membrane proteins. Prot. Sci. 5:1339.
38. Mingarro, I., A. Elofsson, and G. von Heijne. 1997. Helix-helix packing in a membrane like environment. J. Mol. Biol. 272:633.
39. Langosch, D., B. Brosig, H. Kolmar, and H. J. Fritz. 1996. Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator. J. Mol. Biol. 263:525.
40. Caspar-Bauguil, S., J. Arnaud, A. Huchenq, W. R. Hein, C. Geisler, and B. Rubin. 1994. A highly conserved phenylalanine in the αβ-T cell receptor (TCR) constant region determines the integrity of TCR/CD3 complexes. Scand. J. Immunol. 40:323.
41. Geisler, C., B. Rubin, B. S. Caspar, E. Champagne, A. Vangsted, X. Hou, and M. Gajhede. 1992. Structural mutations of C-domains in members of the Ig superfamily: consequences for the interactions between the T cell antigen receptor and the ζ2 homodimer. J. Immunol. 148:3469.
42. Wiest, D. L., W. H. Burgess, D. McKean, K. Kearse, and A. Singer. 1995. The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 compexes. EMBO J. 14: 3425.
43. Luton, F., M. Buferne, V. Legendre, E. Chauvet, C. Boyer, and A. Schmitt-Verhulst. 1997. Role of CD3γ and CD3δ cytoplasmic domains in cytolytic T lymphocyte funclions and TCR/CD3 down-modulation. J. Immunol. 158:4162 .
44. Jacobs, H. 1997. Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signaling properties? Immunol. Today 18:565.
45. Gobel, T. W., and L. Bolliger. 1998. The chicken TCR ζ-chain restores the function of a mouse T cell hybridoma. J. Immunol. 160:1552.
46. Bruyns, E., A. Marie-Cardine, H. Kirchgessner, K. Sagolla, A. Shevchenko, M. Mann, F. Autschbach, A. Bensussan, S. Meuer, and B. Schraven. 1998. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-ζ complex, recruits intracellular signaling proteins to the plasma membrane. J. Exp. Med. 188:561.
47. Lanier, L. L., B. C. Corliss, J. Wu, C. Leong, and J. H. Phillips. 1998. Immunoreceptor DAP-12 bearing a tyrosine-based activation motif is involved in activation of NK cells. Nature 391:703.
48. Von Heijne, G. 1986. Mitochondrial targeting sequences may form amphiphilic helices. EMBO J. 5:1335.
49. Dietrich, J., X. Hou, A. M. K. Wegener, and C. Geisler. 1994. CD3γ contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the TCR. EMBO J. 13:2156.
50. Dietrich, J., J. Kastrup, B. Nielson, N. Odum, and C. Geisler. 1997. Regulation and function of the CD3 γ DxxxLL motif: a binding site for adaptor protein-2 in vitro. J. Cell Biol. 138:271.
51. Cosson, P., and J. Bonifacino. 1992. Role of transmembrane domain interactions in the assembly of class II MHC molecules. Science 258:659.
52. Bernstein, H. D., M. A. Poritz, K. Strub, P. J. Hoben, S. Brenner, and P. Walter. 1989. Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature 340:482.
53. Bolliger, L., T. Junne, G. Schatz, and T. Lithgow. 1995. Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria. EMBO J 14:6318.
54. Dzialo, R. C., and M. Cooper. 1997. An amphibian CD3 homologue of the mammalian CD3γ and δ genes. Eur. J. Immunol. 27:1640.
55. Göbel, T. W., and M. Fluri. 1997. Identification and analysis of the chicken CD3ε gene. Eur. J. Immunol. 27:194.
56. Bernot, A., and C. Auffray. 1991. Primary structure and ontogeny of an avian CD3 transcript. Proc. Natl. Acad. Sci. USA 88:2550.