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Optically pure 2,3-epoxy-1,1,1-trifluoropropane and its synthon are also available in laboratory scales: (a) Bussche-Hunnefeld, C. von der; Cescato, C.; Seebach, D. Chem. Ber. 1992, 125, 2795. (b) Ramachandran, P. V.; Gong, B.; Brown, H. C. J. Org. Chem. 1995, 60, 41. (c) Shimizu, M.; Sugiyama, K.; Fujisawa, T. Bull. Chem. Soc. Jpn. 1996, 69, 2655. (d) Katagiri, T.; Obara, F. Jpn. Kokai Tokkyo Koho 1994, Jp06-247953. (e) Vanhessche, K. P. M.; Sharpless, K. B. Chem. Eur. J. 1997, 3, 517.
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Optically pure 2,3-epoxy-1,1,1-trifluoropropane and its synthon are also available in laboratory scales: (a) Bussche-Hunnefeld, C. von der; Cescato, C.; Seebach, D. Chem. Ber. 1992, 125, 2795. (b) Ramachandran, P. V.; Gong, B.; Brown, H. C. J. Org. Chem. 1995, 60, 41. (c) Shimizu, M.; Sugiyama, K.; Fujisawa, T. Bull. Chem. Soc. Jpn. 1996, 69, 2655. (d) Katagiri, T.; Obara, F. Jpn. Kokai Tokkyo Koho 1994, Jp06-247953. (e) Vanhessche, K. P. M.; Sharpless, K. B. Chem. Eur. J. 1997, 3, 517.
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Optically pure 2,3-epoxy-1,1,1-trifluoropropane and its synthon are also available in laboratory scales: (a) Bussche-Hunnefeld, C. von der; Cescato, C.; Seebach, D. Chem. Ber. 1992, 125, 2795. (b) Ramachandran, P. V.; Gong, B.; Brown, H. C. J. Org. Chem. 1995, 60, 41. (c) Shimizu, M.; Sugiyama, K.; Fujisawa, T. Bull. Chem. Soc. Jpn. 1996, 69, 2655. (d) Katagiri, T.; Obara, F. Jpn. Kokai Tokkyo Koho 1994, Jp06-247953. (e) Vanhessche, K. P. M.; Sharpless, K. B. Chem. Eur. J. 1997, 3, 517.
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Optically pure 2,3-epoxy-1,1,1-trifluoropropane and its synthon are also available in laboratory scales: (a) Bussche-Hunnefeld, C. von der; Cescato, C.; Seebach, D. Chem. Ber. 1992, 125, 2795. (b) Ramachandran, P. V.; Gong, B.; Brown, H. C. J. Org. Chem. 1995, 60, 41. (c) Shimizu, M.; Sugiyama, K.; Fujisawa, T. Bull. Chem. Soc. Jpn. 1996, 69, 2655. (d) Katagiri, T.; Obara, F. Jpn. Kokai Tokkyo Koho 1994, Jp06-247953. (e) Vanhessche, K. P. M.; Sharpless, K. B. Chem. Eur. J. 1997, 3, 517.
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Optically pure 2,3-epoxy-1,1,1-trifluoropropane and its synthon are also available in laboratory scales: (a) Bussche-Hunnefeld, C. von der; Cescato, C.; Seebach, D. Chem. Ber. 1992, 125, 2795. (b) Ramachandran, P. V.; Gong, B.; Brown, H. C. J. Org. Chem. 1995, 60, 41. (c) Shimizu, M.; Sugiyama, K.; Fujisawa, T. Bull. Chem. Soc. Jpn. 1996, 69, 2655. (d) Katagiri, T.; Obara, F. Jpn. Kokai Tokkyo Koho 1994, Jp06-247953. (e) Vanhessche, K. P. M.; Sharpless, K. B. Chem. Eur. J. 1997, 3, 517.
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note
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The PM3 level molecular geometry optimization calculation done by MacSpartan Plus showed that the positive charge on the methylene carbon of N-benzyl-2-trifluoromethylaziridine is 0.15, while that of N-benzyl-2-methylaziridine is 0.04 and that of 2,3-epoxy-1,1,1-trifluoropropane is 0.09. Subtraction of the charge between the methylene carbon and nitrogen of N-benzyl-2-trifluoromethylaziridine is 0.59, while that of N-benzyl-2-methylaziridine is 0.52 and that of 2,3-epoxy-1,1,1-trifluorapropane is 0.32. The LUMO level of N-benzyl-2-trifluoromethylaziridine is -0.002 eV, while that of N-benzyl-2-methylaziridine is +0.298 eV and that of 2,3-epoxy-1,1,1-trifluoropropane is +0.699 eV.
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