Cannabinoid CB1 receptors fail to cause relaxation, but couple via G(i)/G(o), to the inhibition of adenylyl cyclase in carotid artery smooth muscle

British Journal of Pharmacology

Volumn 128, Issue 3, 1999, Pages 597-604

  Holland, Michael ^a,b   Challiss, R A John ^a   Standen, Nicholas B ^a   Boyle, John P ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cannabinoid receptors; CB receptor antagonists; Cyclic AMP; Pertussis toxin; Vasorelaxation

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 [6 METHOXY 2 (4 METHOXYPHENYL) 3 BENZOFURANYLCARBONYL]BENZONITRILE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ADENYLATE CYCLASE; CANNABINOID; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CYCLIC AMP; DEXANABINOL; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; METHANANDAMIDE; PERTUSSIS TOXIN; PHENYLEPHRINE; RIMONABANT; UNCLASSIFIED DRUG; ARACHIDONIC ACID DERIVATIVE; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR CB2, RAT; DRUG RECEPTOR;

ANIMAL TISSUE; ARTERY DILATATION; ARTERY TONE; ARTICLE; CAROTID ARTERY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULATION; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; METABOLISM; MUSCLE RELAXATION; MUSCLE TONE; PHYSIOLOGY; WISTAR RAT;

ADENYLATE CYCLASE; ANIMALS; ARACHIDONIC ACIDS; CAROTID ARTERIES; CYCLIC AMP; FORSKOLIN; GTP-BINDING PROTEINS; MALE; MUSCLE RELAXATION; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0033209957     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702842     Document Type: Article

References (30)

1. BLOOM, A.S., TERSHNER, S., FULLER, S.A. & STEIN, E.A. (1997). Cannabinoid-induced alterations in regional cerebral blood flow in the rat. Pharmacol. Biochem. Behav., 57, 625-631.
2. BROWN, B.L., ALBANO, J.D.M., SGHERZI, A.M. & TAMPION, W. (1971). A simple and sensitive saturation assay method for the measurement of adenosine 3', 5'-monophosphate. Biochem. J., 121, 561-563
3. 1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. Br. J. Pharmacol., 123, 968-974.
4. 1 receptor to stimulation of cAMP accumulation. J. Pharmacol. Exp. Ther., 284, 291-297.
5. 2 receptors. Mol. Pharmacol., 48, 443-450.
6. FLEMING, I., SCHERMER, B., POPP, R. & BUSSE, R. (1999). Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists. Br. J. Pharmacol., 126, 949-960.
7. HARRIS, D., KENDALL, D.A. & RANDALL, M.D. (1999). Characterisation of cannabinoid receptors coupled to vasorelaxation by endothelium-derived hyperpolarizing factor. Naunyn-Schmiedeberg's Arch. Pharmacol., 359, 48-52.
8. HOWLETT, A.C. (1996). Pharmacology of cannabinoid receptors. Annu. Rev. Pharmacol. Toxicol., 35, 607-634.
9. 1-like cannabinoid receptors. J. Pharmacol. Exp. Ther., 281, 1030-1037.
10. LÓPEZ-REDONDO, F., LEES, G.M. & PERTWEE, R. G. (1997). Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum. Br. J. Pharmacol., 122, 330-334.
11. MACKIE, K. & HILLE, B. (1992). Cannabinoids inhibit N-type calcium channels in neuroblastoma glioma-cells. Proc. Natl. Acad. Sci. U.S.A., 89, 3825-3829.
12. 1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat. Naunyn-Schmiedeberg's Arch. Pharmacol., 356, 197-202.
13. NIEDERHOFFER, N. & SZABO, B. (1999a). Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation. Br. J. Pharmacol., 126, 457-456.
14. 1 cannabinoid receptors in the EDHF-dependent vasorelaxation in rabbits. Br. J. Pharmacol., 126, 1383-1386.
15. 1 receptors in mouse vas deferens. Eur. J. Pharmacol., 296, 169-172.
16. PLANE, F., HOLLAND, M., WALDRON, G.J., GARLAND, C.J. & BOYLE, J.P. (1997). Evidence that anandamide and EDHF act via different mechanisms in rat isolated mesenteric arteries. Br. J. Pharmacol., 121, 1509-1511.
17. QUAYLE, J.M., NELSON, M.T. & STANDEN, N.B. (1997). ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol. Rev., 77, 1165-1232.
18. RANDALL, M.D., ALEXANDER, S.P.H., BENNETT, C.F., BOYD, E.A., FRY, J.R., GARDINER, S.M., KEMP, P.A., MCCULLOCH, A.I. & KENDALL, D.A. (1996). An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biohem. Biophys. Rev. Commun., 229, 114-120.
19. RANDALL, M.D. & KENDALL, D.A. (1998). Endocannabinoids: a new class of vasoactive substances. Trends Pharmacol. Sci., 19, 55-58.
20. 1 cannabinoid receptor isoforms. J. Pharmacol. Exp. Ther., 278, 871-878.
21. SHIRE, D., CALANDRA, B., RINALDI-CARMONA, M., OUSTRIC, D., PESSEGUE, B., BONNINCABANNE, O., LEFUR, G., CAPUT, D. & TERRARA, P. (1996). Molecular-cloning, expression and function of the murine cb2 peripheral cannabinoid receptor. Biochim. Biophys. Acta, 1307, 132-136.
22. SLIPETZ, D.M., ONEILL, G.P., FAVREAU, L., DUKRESNE, C., GALLANT, M., GAREAU, Y., GUAY, D., LABELLE, M, & METTERS, K.M. (1995). Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Mol. Pharmacol., 48, 352-361.
23. VARGA, K., LAKE, K.D., HUANGFU, D., GUYENET, P.G. & KUNOS, G. (1996). Mechanism of the hypotensive action of anandamide in anesthetized rats. Hypertension, 28, 682-686.
24. 1 cannabinoid receptor in the hypotensive action of anandamide. Eur. J. Pharmacol., 278, 279-283.
25. VENANCE, L., SAGAN, S. & GIAUME, C. (1997). (R)-methanandamide inhibits receptor-induced calcium responses by depleting internal calcium stores in cultured astrocytes. Fflügers Arch., 434, 147-149.
26. VIDRIO, H., SANCHEZSALVATORI, M.A. & MEDINA, M. (1996). Cardiovascular effects of (-)-11-Oh-delta(8)-Tetrahydrocannabinol-dimethylheptyl in rats. J. Cardiovasc. Pharmacol., 28, 332-336.
27. 1 cannabinoid receptors in haemorrhagic shock. Nature, 390, 518-521.
28. WHITE, R. & HILEY, C.R. (1997). A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. Br. J. Pharmacol., 122, 1573-1584.
29. WHITE, R. & HILEY, C.R. (1998). The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery. Br. J. Pharmacol., 125, 533-541.
30. ZYGMUNT, P.M., HÖGESTÄTT, E.D., WALDECK, K., EDWARDS, G., KIRKUP, A. & WESTON, A.H. (1997). Studies on the effects of anandamide in rat hepatic artery. Br. J. Pharmacol., 122, 1679-1686.