Gender dimorphism in trauma-hemorrhage-induced thymocyte apoptosis

Shock

Volumn 12, Issue 4, 1999, Pages 316-322

  Angele, Martin K ^a   Xu, Ying Xin ^a   Ayala, Alfred ^a   Schwacha, Martin G ^a   Catania, Robert K ^a   Cioffi, William G ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE;

ANIMAL; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; BLEEDING; C3H MOUSE; CELL COUNT; CELL CULTURE; FEMALE; IMMUNOPHENOTYPING; INJURY; MALE; MOUSE; PATHOLOGY; PHYSIOLOGY; SEXUAL DEVELOPMENT; THYMUS;

ANIMALS; ANTIBODY FORMATION; APOPTOSIS; CELL COUNT; CELLS, CULTURED; DIHYDROTESTOSTERONE; FEMALE; HEMORRHAGE; IMMUNOPHENOTYPING; MALE; MICE; MICE, INBRED C3H; SEX CHARACTERISTICS; THYMUS GLAND; WOUNDS AND INJURIES;

EID: 0033208727     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199910000-00011     Document Type: Article

References (39)

1. Olsen NJ, Kovacs WJ: Gonadal Steroids and immunity. Endocr Rev 17: 369-384, 1996.
2. Bone RC: Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA 268:3452-3455, 1992.
3. Center for Disease Control: Mortality patterns-United States, 1989. MMWR 41:121-125, 1992.
4. Zellweger R, Ayala A, Stein S, DeMaso CM, Chaudry IH: Females in proestrus state tolerate sepsis better than males. Crit Care Med 25:106-110, 1997.
5. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH: Enhanced immune responses in females as opposed to decreased responses in males following hemorrhagic shock. Cytokine 8:853-863, 1996.
6. Wichmann MW, Ayala A, Chaudry IH: Male sex steroids are responsible for depressing macrophage immune function after trauma-hemorrhage. Am J Physiol 273:C1335-C1340, 1997.
7. Angele MK, Ayala A, Monfils BA, Cioffi WG, Bland KI, Chaudry IH: Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. J Trauma 44:78-85, 1998.
8. Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH: Testosterone: the culprit for producing splenocyte immune depression following trauma-hemorrhage. Am J Physiol 274:C1530-C1536, 1998.
9. Calzolari A: Recherches experimentales sur un rapport probable entre la function du thymus et celle des testicules. Arch Ital Biol 30:71-77, 1988.
10. Xin Xu Y, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH: Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF. J Surg Res 68:24-30, 1997.
11. Schneider EM, Lorenz I, Leippold S, Zischler H, Clark SC, Wernet P: Generation of mature CD3+ and T cell receptor (TCR) + T cells from a leukemic analogue of the putative human stem cell by T cell conditioned medium containing IL-3, IL-2, and GM-CSF. Leukemia 2:282-289, 1988.
12. Mossalayi MD, Dalloul AH, Bertho JM, Lecron JC, deLaforest PG, Debre P: In vitro differentiation and proliferation of purified human thymic and bone marrow CD7+CD2-T-cell precursors. Exp Hematol 18:326-331, 1990.
13. Duke RC, Cohen JJ: IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T-cells. Lymphokine Res 5:289-299, 1986.
14. Ayala A, Herdon CD, Lehman DL, Ayala CA, Chaudry IH: Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and nature of the mediators. Blood 87:4261-4275, 1996.
15. Ayala A, Karr SM, Evans TA, Chaudry IH: Factors responsible for peritoneal granulocyte apoptosis during sepsis. J Surg Res 69:67-75, 1997.
16. Zellweger R, Ayala A, DeMaso CM, Chaudry IH: Trauma-hemorrhage causes prolonged depression in cellular immunity. Shock 4:149-153, 1995.
17. Chaudry IH, Ayala A, Ertel W, Stephan RN: Editorial review. Hemorrhage and resuscitation: immunological aspects. Am J Physiol 259:R663-R678, 1990.
18. Sprent J: T lymphocytes and the thymus. In Paul WE (ed): Fundamental Immunology. New York: Raven Press Ltd., 1993, pp 75-109.
19. Castro JE: Orchidectomy and the immune response. II. Response of orchidectomized mice to antigens. Proc R Soc Lond B Biol Sci 185:437-451, 1974.
20. Kawashima I, Sakabe K, Seiki K, Fujii-Hanamoto H: Effect of sex steroids on T cell differentiation in the thymus of castrated C57BL/6NJcl mice. Med Sci Res 18:261-262, 1990.
21. Sheridan PJ: Can a single androgen receptor fill the bill? Mol Cell Endocrinol 76:C39-C45, 1991.
22. Viselli SM, Olsen NJ, Shults K, Steizer G, Kovacs WJ: Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes. Mol Cell Endocrinol 109:19-26, 1995.
23. Olsen NJ, Viselli SM, Fan J, Kovacs WJ: Androgens accelerate thymocyte apoptosis. Endocrinology 139:748-752, 1998.
24. Barr IG, Khalid BAK, Pearce P, Toh BH, Bartlett PF, Scollay RG, Funder JW: Dihydrotestosterone and estradiol deplete corticosensitive thymocytes lacking in receptors for these hormones. J Immunol 128:2825-2828, 1982.
25. Greenstein BD, Fitzpatrick F, Adcock IM, Kendall MD, Wheeler MJ: Reappearance of the thymus in old rats after orchidectomy: inhibition of regeneration by testosterone. J Endocrinol 110:417-422, 1986.
26. Olsen NJ, Watson MB, Henderson GS, Kovacs WJ: Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice. Endocrinology 129:2471-2476, 1991.
27. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH: Mechanisms of immunosuppression in males following trauma-hemorrhage: critical role of testosterone. Arch Surg 131:1186-1192, 1996.
28. Compton MM, Cidlowski JA: Rapid in vivo effects of glucocorticoids on the integrity of rat lymphocyte genomic deoxyribonucleic acid. Endocrinology 118:38-45, 1986.
29. Zellweger R, Zhu X, Wichmann MW, Ayala A, DeMaso CM, Chaudry IH: Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis. J Immunol 157:5748-5754, 1996.
30. Lin YS, Lei HY, Low TLK, Shen CL, Chou LJ, Jan MS: In vivo induction of apoptosis in immature thymocytes by staphylococcal enterotoxin B. J Immunol 149:1156-1163, 1992.
31. Nakanishi T, Nishi Y, Sato EF, Ishii M, Hamada T, Inoue M: Thermal injury induces thymocyte apoptosis in the rat. J Trauma 44:143-148, 1998.
32. Barke RA, Roy S, Chapin RB, Charboneau R: The role of programmed cell death (apoptosis) in thymic involution following sepsis. Arch Surg 129:1256-1262, 1994.
33. Kumar N, Shan LX, Hardy MP, Bardin CW, Sundaram K: Mechanism of androgen-induced thymolysis in rats. Endocrinology 136:4887-4893, 1995.
34. Greenstein BD, deBridges EF, Fitzpatrick FT: Aromatase inhibitors regenerate the thymus in aging male rats, Int J Immunopharmacol 14:541-553, 1992.
35. Samy TSA, Ayala A, Catania RA, Chaudry IH: Trauma-hemorrhage ac-tivates signal transduction pathways in mouse splenic T-cells. Shock 9: 443-450, 1998.
36. Samy TSA, Schwacha MG, Chung C, Cioffi WG, Bland KI, Chaudry IH: Proteosoma participates in the alteration of signal transduction in T and B lymphocytes following trauma-hemorrhage. Biochim Biophys Acta 1453: 92-104, 1999.
37. Ayala A, Herdon CD, Lehman DL, DeMaso CM, Ayala CA, Chaudry IH: The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor. Shock 3:259-267, 1995.
38. Janeway JR: How the immune system discriminates infections nonself from noninfectious self. In Faist E, Meakins J, Schildberg FW (eds:) Host Defense Dysfunction in Trauma, Shock and Sepsis. Berlin-Heidelberg: Springer-Verlag, 1993, pp 39-47.
39. Ayala A, Ertel W, Chaudry IH: Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. Shock 5:79-90, 1996.