K-Ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat

Tohoku Journal of Experimental Medicine

Volumn 189, Issue 2, 1999, Pages 87-93

  Tanoguchi, Koji ^a   Yaegashi, Nobuo ^a   Jiko, Kumiko ^a   Maekawa, Akihiko ^b   Sato, Shinji ^a   Yajima, Akira ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SASAKI INSTITUTE   (Japan)

Author keywords

Donyu rat; Dot blot hybridization; Endometrial carcinoma; Point mutation; Ras

Indexed keywords

DNA;

ADENOCARCINOMA; ANIMAL; ARTICLE; CELL TRANSFORMATION; CODON; COMPARATIVE STUDY; ENDOMETRIUM; ENDOMETRIUM TUMOR; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; HYPERPLASIA; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PATHOLOGY; POINT MUTATION; RAT; RAT STRAIN; SPECIES DIFFERENCE;

ADENOCARCINOMA; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CODON; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERPLASIA; POINT MUTATION; RATS; RATS, INBRED STRAINS; SPECIES SPECIFICITY;

EID: 0033205471     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.189.87     Document Type: Article

References (20)

1. Bokhman, J.V. (1983) Two pathogenetic types of endometrial carcinoma. Gynecol. Oncol., 15, 10-17.
2. Bos, J.L. (1989) Ras oncogenes in human cancer: A review. Cancer Res., 49, 4682-4689.
3. Deligdisch, L. & Holinka, C.F. (1987) Endometrial carcinoma: Two diseases? Cancer Detect. Prev., 10, 237-246.
4. Duggan, B.D., Felix, J.C., Muderspach, L.I., Tsao, J.-L. & Shibata, D.K. (1994) Early mutational activation of the c-Ki-ras oncogene in endometrial carcinoma. Cancer Res., 54, 1604-1607.
5. Enomoto, T., Inoue, M., Perantoni, A.O., Terakawa, N., Tanizawa, O. & Rice, J.M. (1990) K-ras activation in neoplasms of the human female reproductive tract. Cancer Res., 50, 6139-6145.
6. Enomoto, T., Inoue, M., Perantoni, A.O., Buzard, G.S., Miki, H., Tanizawa, O. & Rice, J.M. (1991) K-ras activation in premalignant and malignant epithelial lesions of the human uterus. Cancer Res., 51, 5308-5314.
7. Enomoto, T., Fujita, M., Inoue, M., Rice, J.M., Nakajima, R., Tanizawa, O. & Nomura, T. (1993) Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium. Cancer Res., 53, 1883-1888.
8. Fearon, E.R. & Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
9. Ignar-Trowbridge, D., Risinger, J.I., Dent, G.A., Kohler, M., Berchuck, A., McLachlan, J.A. & Boyd, J. (1992) Mutations of the Ki-ras oncogene in endometrial carcinoma. Am. J. Obstet. Gynecol., 167, 227-232.
10. Ito, K., Watanabe, K., Nasim, S., Sasano, H., Sato, S., Yajima, A., Silverberg, S.G. & Garrett, C.T. (1994) Prognostic significance of p53 overexpression in endometrial cancer. Cancer Res., 54, 4667-4670.
11. Kato, K., Ueoka, Y., Kato, K., Hachiya, T., Nishida, J. & Wake, N. (1997) Contribution of enhanced transcriptional activation by ER to [12Val] K-ras mediated NIH3T3 cell transformation. Oncogene, 15, 3037-3046.
12. Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T. & Uchiyama, S. (1995) Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science, 270, 1491-1494.
13. Kurman, R.J. (1994) Blaustein's Pathology of the Female Genital Tract, 4th ed., edited by Robert K. Kurman, Springer-Verlag, 439-478.
14. Maekawa, A. (1994) Genital tumors in female rats; Influence of chemicals and/or hormones and host factors on their occurrence. J. Toxicol. Sci., 19, 119-132.
15. Mizuuchi, H., Nasim, S., Kudo, R., Silverberg, S.G., Greenhouse, S. & Garrett, C.T. (1992) Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium. Cancer Res., 52, 2777-2781.
16. Nagaoka, T., Onodera, H., Matsushima, Y., Todate, A., Shibutani, M., Ogasawara, H. & Maekawa, A. (1990) Spontaneous uterine adenocarcinomas in aged rats and their relation to endocrine imbalance. J. Cancer Res. Clin. Oncol., 116, 623-628.
17. Nagaoka, T., Takeuchi, M., Onodera, H., Matsushima, Y., Ando-lu, J. & Maekawa, A. (1994) Sequential observation of spontaneous endometrial adenocarcinoma development in Donryu rats. Toxicol. Pathol., 22, 261-269.
18. Sasaki, H., Nishii, H., Takahashi, H., Tada, A., Furusato, M., Terashima, Y., Siegal, G.P., Parker, S.L., Kohler, M.F., Berchuck, A. & Boyd, J. (1993) Mutation of the Ki-ras protooncogene in human endometrial hyperplasias and carcinoma. Cancer Res., 53, 1906-1910.
19. Sato, S., Ito, K., Ozawa, N., Yajima, A. & Sasano, H. (1991) Analysis of point mutations at codon 12 of K-ras in human endometrial carcinoma and cervical adenocarcinoma by dot blot hybridization and polymerase chain reaction. Tohoku J. Exp. Med., 165, 131-136.
20. Silverberg, S.G., Mullen, D., Faraci, J.A., Makowski, E.L., Miller, A., Finch, J.L. & Sutherland, J.V. (1980) Endometrial carcinoma: Clinical-pathologic comparison of cases in postmenopausal women receiving and not receiving exogenous estrogens. Cancer, 45, 3018-3026.