Model-based scale-up strategy for mycelial fermentation processes

Canadian Journal of Chemical Engineering

Volumn 77, Issue 5, 1999, Pages 844-854

  Yang, He ^a,b   Allen, D Grant ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b Northwestern University   (United States)

Author keywords

Bioreactor scale up; Filamentous growth; Modeling; Mycelial fermentations; Optimization

Indexed keywords

BIOREACTORS; COMPUTER SIMULATION; FERMENTATION; MASS TRANSFER; MATHEMATICAL MODELS; MORPHOLOGY; OPTIMIZATION; RHEOLOGY;

FILAMENTOUS GROWTH;

CELL CULTURE;

EID: 0033203770     PISSN: 00084034     EISSN: None     Source Type: Journal    
DOI: 10.1002/cjce.5450770509     Document Type: Article

References (36)

1. Allen, D. G. and C. W. Robinson, "Hydrodynamics and Mass Transfer in Aspergillus niger Fermentations in Bubble Column and Loop Bioreactors", Biotechnol. Bioeng. 34, 731-740 (1989).
2. Allen, D. G. and C. W. Robinson, "Measurement of Rheological Properties of Filamentous Fermentation Broths", Chem. Eng. Sci. 45, 37-48 (1990).
3. Blanch, H. W. and S. M. Bhavaraju, "Bioengineering Report -Non-Newtonian Fermentation Broths: Rheology and Mass Transfer", Biotechnol. Bioeng. 18, 745-790 (1976).
4. Calderbank, P. H. and M. B. Moo-Young, "The Prediction of Power Consumption in the Agitation of non-Newtonian Fluids", Trans. Inst. Chem. Eng. 37, 26-33 (1959).
5. Collinge, A. J. and P. Markam, "Woronin Bodies Rapidly Plug Septal Pores of Severed Penicillium chrysogenum Hyphae", Exp. Mycol. 9, 80-85. (1985).
6. Croughan, M. S., J. F. Hamel and D. I. C. Wang, "Hydrodynamic Effects on Animal Cells Grown in Microcarrier Cultures", Biotechnol. Bioeng. 29, 130-141 (1987).
7. Dion, W. M. and R. Kaushal, "The Effect of Mechanical Agitation on the Morphology of Some Common Fungi Grown on Submerged Culture", Sel. Sci. Papers Inst. Super Sanitar. 2, 357-369 (1959).
8. Gbewonyo, K., D. DiMasi and B. C. Buckland, "The Use of Hydrofoil Impellers to Improve Oxygen transfer Efficiency in Viscous Mycelial Fermentations", in "Proceeding of the International Conference on Bioreactor Fluid Dynamics", Cambridge, England (1986), pp. 281-299.
9. Hickman, A. D. and A. W. Nienow, "Mass Transfer and Hold-up in an Agitated Simulated Fermentation Broth as a Function of Viscosity", in "Proceeding of the International Conference on Bioreactor Fluid Dynamics", Cambridge, England (1986), pp. 301-315.
10. Hubbard, D. W., "Scaleup Strategies for Bioreactors Containing Non-Newtonian Broths", Ann. New York Acad. Sci. 506, 600-606 (1987).
11. Kawase, Y. and M. Moo-Young, "Volumetric Mass Transfer Coefficients in Aerated Stirred Tank Reactors with Newtonian and Non-Newtonian", Trans. Inst. Chem. Eng. 66, 284-288 (1988).
12. Makagiansar, H. Y., P. Ayazi Shamlou, C. R. Thomas and M. D. Lilly, "The Influence of Mechanical Force on the Morphology and Penicillin Production of Penicillium chrysogenum", Bioprocess Eng. 9, 83-90 (1993).
13. Metz, B., "From Pulp to Pellet: An Engineering Study on the Morphology of Moulds", PhD thesis, Technical University of Delft, Delft, Netherlands (1976).
14. Metzner, A. B. and R. E. Otto, "Agitation of Non-Newtonian Fluids", AIChE J. 3, 3-10 (1957).
15. Michel, B. J. and S. A. Miller, "Power Requirements of Gas - Liquid Agitated Systems", AIChE J. 8, 262-266 (1962).
16. Mohseni, M. and D. G. Allen, "The Effect of Particle Morphology on the Directly Measured Yield Stress", Biotechnol. Bioeng. 48, 257-265 (1995).
17. Moo-Young, M. and H. W. Blanch, "Design of Biochemical Reactor: Mass Transfer Criteria for Simple and Complex Systems", Adv. in Biochemical Eng. 19, 1-69 (1981).
18. Nestaas, E. and D. I. C. Wang, "The 'Filtration Probe' for Quantitative Characterization of the Penicillin Fermentation, I. Mycelial Morphology and Culture Activity", Biotechnol. Bioeng. 23, 2803-2813 (1981).
19. Nestaas, E. and D. I. C. Wang, "Computer Control of the Penicillin Fermentation Using the Filtration Probe in Conjunction with a Structured Process Model", Biotechnol. Bioeng. 25, 781-796 (1983).
20. Popovic, M. and C. W. Robinson, "Mass Transfer Studies of External-Loop Airlifts and a Bubble Column", AIChE J. 35, 393-405 (1989).
21. Prosser, J. I. and A. P. J. Trinci, "A Model for Hyphal Growth and Branching", J. Gen. Microbiol. 111, 153-164 (1979).
22. Reichel, U., H. Yang, E. D. Gilles, H. Wolf, "An Improved Method for Measuring the Interseptal Spacing in Hyphae of Streptomyces tendae by Fluorescence Microscopy Coupled with Image Processing", FEMS Microbiol. Letters, 67, 207-210 (1990).
23. nd edition, VCH, Weinheim, Germany (1993), pp. 185-217.
24. Righelato, R. C., A. P. J. Trinci, S. J. Pirt and A. Peat, "The Influence of Maintenance Energy and Growth Rate on Metabolic Activity, Morphology, and Conidiation of Penicillium chrysogenum", J. Gen. Microbiol. 50, 399-412 (1968).
25. Singh, V., R. Fuchs and A. Constantinides, "A New Method for Fermenter Scale-up Incorporating Both Mixing and Mass Transfer Effects (I. Theoretical Basis", in "Biotechnology Processes - Scale-up and Mixing", C. S. Ho and J. Y. Oldshue, Eds. (1987), pp. 200-214.
26. Smith, J. J., M. D. Lilly and R. I. Fox, "The Effect of Agitation on the Morphology and Penicillin Production of Penicillium chrysogenum", Biotechnol. Bioeng. 35, 1011-1023 (1990).
27. Tanaka, H. "Studies on the Effect of Agitation on Mycelial Strength in Submerged Culture", J. Ferment. Technol. 54, 818-829 (1976).
28. Tanaka, H., J. Takahashi and K. Ueda, "An Index Representing the Mycelial Strength to Maintain Physiological Activity on Mechanical Agitation", J. Ferment. Technol. 53, 35-43 (1975).
29. Tucker, K. G. and C. R. Thomas, "Effect of Biomass Concentration and Morphology on the Rheological Parameters of Penicillium chrysogenum Fermentation Broths", Food Bioprod. Proc. 71, 111-117 (1993).
30. Ujcova, E., Z. Fencl, M. Musilkova and L. Seichert, "Dependence of Release of Nucleotides from Fungi on Fermenter Turbine Speed", Biotechnol. Bioeng. 22, 237-241 (1980).
31. van't Riet, K., "Review of Measuring Methods and Results in Nonviscous Gas-Liquid Mass Transfer in Stirred Vessels", Ind. Eng. Chem. Process Des. Dev. 18, 357-364 (1979).
32. van Suijdam, J. C. and B. Metz, "Influence of Engineering Variables upon the Morphology of Filamentous Molds", Biotechnol. Bioeng. 23, 111-148 (1981).
33. Wu, H. and G. K. Patterson, "Laser-Doppler Measurements of Turbulent-Flow Parameters in a Stirred Mixer", Chem. Eng. Sci. 44, 2207-2221 (1989).
34. Yang, H., "Mathematical Model for Filamentous Growth of Mycelial Microorganisms in Lab Chambers and in Batch, Fed-Batch and Continuous Cultures", in "Progress in Biotechnology 9", L. Alberghina, L. Frontali and P. Sensi, Eds., Elsevier Science B.V., Amsterdam (1994), pp. 845-848.
35. Yang, H., U. Reichl, R. King and E. D. Gilles, "Measurement and Simulation of the Morphological Development of Filamentous Microorganisms", Biotechnol. Bioeng. 39, 44-48 (1992a).
36. Yang, H., R. King, U. Reichl and E. D. Gilles, "Mathematical Model for Apical Growth, Septation, and Branching of Mycelial Microorganisms", Biotechnol. Bioeng. 39, 49-58 (1992b).