Stability of ganciclovir in extemporaneously compounded oral liquids

American Journal of Health-System Pharmacy

Volumn 56, Issue 17, 1999, Pages 1738-1741

  Anaizi, Nasr H ^a,b   Swenson, Chad F ^c   Dentinger, Paul J ^c  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c NONE

Author keywords

Antivirals; Compounding; Containers; Formulations; Ganciclovir sodium; Incompatibilities; Liquids; Polyethylene terephthalate; Stability; Storage; Sweetening agents

Indexed keywords

GANCICLOVIR; POLYETHYLENE TEREPHTHALATE; SUGAR;

ARTICLE; COLOR; CONTROLLED STUDY; DRUG FORMULATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID; MICROBIAL GROWTH; ODOR; ORAL DRUG ADMINISTRATION; PH; PRIORITY JOURNAL; TEMPERATURE;

EID: 0033200318     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/56.17.1738     Document Type: Article

References (11)

1. Crumpacker CS. Ganciclovir. N Engl J Med. 1996; 335:721-8.
2. Hebart H, Kanz L, Jahn G et al. Management of cytomegalovirus infection after solid-organ or stem-cell transplantation. Current guidelines and future prospects. Drugs. 1998; 55:59-72.
3. Gane E, Saliba F, Valdecasas GJ et al. Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients. Lancet. 1997; 350:1729-33.
4. Ahsan N, Holman MJ, Yang HC. Efficacy of oral ganciclovir in the prevention of cytomegalovirus infection in post-kidney transplant patients. Clin Transplant. 1997; 11:633-9.
5. Filler G, Lampe D, von Bredow MA. Prophylactic oral ganciclovir after renal transplantation - dosing and pharmacokinetics. Pediatr Nephrol. 1998; 12(1):6-9.
6. Visor GC, Lin L, Jackson SE et al. Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections. Am J Hosp Pharm. 1986; 43:2810-2.
7. Silvestri AP, Mitrano FP, Baptista RJ et al. Stability of ganciclovir sodium in 5% dextrose injection over 35 days. Am J Hosp Pharm. 1991; 48:2641-3.
8. Parasrampuria J, Li LC, Stelmach AH et al. Stability of ganciclovir sodium in 5% dextrose injection and 0.9% sodium chloride injection over 35 days. Am J Hosp Pharm. 1992; 49: 116-8.
9. Anaizi NH, Swenson CF. Instability of aqueous captopril solutions. Am J Hosp Pharm. 1993; 50:486-8.
10. Roth D, Colon J, Burk GW et al. Primary immunosuppression with tacrolimus and mycophenolate mofetil for renal allograft recipients. Transplantation. 1998; 65:248-52.
11. Moxey-Mims MM, Kay C, Light JA et al. Increased incidence of insulin-dependent diabetes mellitus in pediatric renal transplant patients receiving tacrolimus (FK506). Transplantation. 1998; 65:617-9.