Decreased mitogen response of splenocytes in senescence accelerated mice (SAM-P1) is not restored by high vitamin E diet

Nutrition Research

Volumn 19, Issue 9, 1999, Pages 1393-1400

  Muraga, Mikako ^a   Umegaki, Keizo ^b   Yamaraoto, Shigeru ^c   Moriguchi, Satoru ^a  

^a YAMAGUCHI PREFECTURAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Macrophages; Mitogenesis; Senescence Accelerated Mouse (SAM); Splenic lymphocytes; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CONCANAVALIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALE; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SPLEEN CELL; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ANIMALIA;

EID: 0033199058     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0271-5317(99)00096-2     Document Type: Article

References (18)

1. Moriguchi S, Maekawa K, Miwa H, Kishino Y. Effect of vitamin E supplementation on cellular immune functions deccreased with aging in spontaneously hypertensive rats. Nutr Res 1993; 13: 1039-1051.
2. Moriguchi S, Maekawa K, Okamura M, Oonishi K, Kishino Y. Vitamin E prevents the decrease of cellular immune function with aging in spontaneously hypertensive rats. Nutr Res 1995; 15: 401-414.
3. Takeda T, Hosokawa M, Takeshita S, Irino M, Matsushita T, Tomita Y, Yasuhira K, Hamamoto H, Shimizu K, Ishii M, Yamamuro T. A new murine model of accelerated senescence. Mech Ageing Dev 1981; 17: 183-194.
4. Umezawa M, Hanada K, Naiki H, Chen WH, Hosokawa M, Hosono M, Hosokawa T, Takeda T. Effects of dietary restriction on age-related immune dysfunction in the senescence accelerated mouse (SAM). J Nutr 1990; 120: 1393-1400.
5. Moriguchi S, Kobayashi N, Kishino Y. High dietary intakes of vitamin E and cellular immune functions in rats. J Nutr 1990; 120: 1096-1102.
6. Oonishi K, Moriguchi S, Kishino Y. The role of macrophages in increased mitogen response of rat splenic lymphocytes following in vitro incubation with vitamin E. J Nutr Sci Vitaminol 1995; 41: 445-453.
7. Murata T, Tamai H, Morinobu T, Manago M, Takenaka A, Mino M. Determination of β-carotene in plasma, blood cells and buccal mocosa by electrochemical. Lipid 1992; 27: 840-843.
8. Sakai S, Moriguchi S. Long-term feeding of high vitamin E diet improves the decreased mitogen response of rat splenic lymphocytes with aging. J Nutr Sci Vitaminol 1997; 43: 113-122.
9. Moriguchi S, Miwa H, Okamura M, Maekawa K, Kishino Y, Maeda K. Vitamin E is an important factor in T cell differentiation in thymus of F344 rats. J Nutr Sci Vitaminol 1993; 39: 451-463.
10. Moriguchi S, Itoh T. Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus. Nutr Res 1997; 5: 873-883.
11. - productions in rat peritoneal macrophages. Biochim Biophys Acta 1991; 1074: 251-255.
12. 2 synthesis and enhances the immune response in aged mice. Mech Ageing Dev 1986; 34: 191-201.
13. Kumar A, Singh SM. Effect of tumor growth on the blastogenic response of splenocytes: A role of macrophage-derived nitric oxide. Immunol Invest 1996; 25; 413-423.
14. Ahvazi BC, Jacobs P, Stevenson MM. Role of macrophage-derived nitric oxide in suppression of lymphocyte proliferation during blood-stage malaria. J Leukoc Biol 1995; 58: 23-31.
15. Krenger W, Falzarano G, Delmonte J Jr, Snyder KM, Byon JC, Ferrara JL. Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease. Blood 1996; 88: 1113-1121.
16. Lee KU. Nitric oxide produced by macrophages mediates suppression of con A-induced proliferative responses of splenic leukocytes in the diabetes-prone BB rat. Diabetes 1994; 43: 1218-1220.
17. Rossi GR, Cervi LA, Sastre DA, Masih DT. Lack of involvement of nitric oxide in the macrophage-mediated inhibition of spleen cell proliferation during experimental cryptococcosis. Clin Immunol Immunopathol 1998; 86: 16-26.
18. Inada K, Yokoi I, Kabuto H, Habu H, Mori A, Ogawa N. Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger. Mech Ageing Dev 1996; 89: 95-102.