A new look at hypersensitivity pneumonitis

Current Opinion in Pulmonary Medicine

Volumn 5, Issue 5, 1999, Pages 299-304

  Ando, Masayuki ^a   Suga, Moritaka ^a   Kohrogi, Hirotsuga ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; CYTOKINE; ERYTHROMYCIN; GLYCOPROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MUC1 PROTEIN, HUMAN; MUCIN; PEPTIDE FRAGMENT; PROCOLLAGEN; PROCOLLAGEN TYPE III N TERMINAL PEPTIDE; PROCOLLAGEN TYPE III-N-TERMINAL PEPTIDE; TUMOR ANTIGEN;

ALLERGIC PNEUMONITIS; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; BLOOD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC DISEASE; GRANULOMA; HUMAN; IMMUNOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; REVIEW; TH1 CELL; TH2 CELL;

ALVEOLITIS, EXTRINSIC ALLERGIC; ANTI-BACTERIAL AGENTS; ANTIGEN PRESENTATION; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; ANTIGENS, NEOPLASM; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CYTOKINES; ERYTHROMYCIN; GLYCOPROTEINS; GRANULOMA; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MAJOR HISTOCOMPATIBILITY COMPLEX; MUCINS; PEPTIDE FRAGMENTS; PROCOLLAGEN; TH1 CELLS; TH2 CELLS;

EID: 0033190829     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/00063198-199909000-00006     Document Type: Article

References (49)

1. Richerson HB, Bernstein IL, Fink JN, Hunninghake GW, Novey HS, Reed CE, et al,: Guidelines for the clinical evaluation of hypersensitivity pneumonitis: report of the subcommittee on hypersensitivity pneumonitis. J Allergy Clin Immunol 1989, 84:839-844.
2. Salvaggio JE: Extrinsic allergic alveolitis (hypersensitivity pneumonitis): past, present and future. Clin Exp Allergy 1997, 27:18-25.
3. Kaltreider HB: Hypersensitivity pneumonitis. West J Med 1993, 159:570-578.
4. Suga M, Yamasaki H, Nakagawa K, Kohrogi H, Ando M: Mechanisms accounting for granulomatous responses in hypersensitivity pneumonitis. Sarcoidosis Vasc Diffuse Lung Dis 1997, 14:131-138.
5. Murayama J, Yoshizawa Y, Sato T, Ishikawa H, Ohtsuka M, Inoue T, et al.: A compartmentalized bias for T-cell receptor Vβ usage in summer-type hypersensitivity pneumonitis. Int Arch Allergy Immunol 1995, 107:581-586.
6. Trentin L, Zambello R, Facco M, Tassinari C, Sancetta R, Siviero M, et al.: Selection of T lymphocytes bearing limited TCR-Vβ regions in the lung of hypersensitivity pneumonitis and sarcoidosis. Am J Respir Crit Care Med 1997, 155:587-596. TCR-Vβ gene usage was analyzed on both lung and blood lymphocytes and demonstrated a bias in the expression of some Vβ region products in the lung of the patients as compared with the blood and lung of normal subjects.
7. Shigematsu M, Nagai S, Nishimura K, Izumi T, Eklund AG, Grunewald J: Summer-type hypersensitivity pneumonitis: T-cell receptor V gene usage in BALF T-cells from 3 cases in one family. Sarcoidosis Vasc Diffuse Lung Dis 1998, 15:173-177.
8. + T-cells normalized with clinical movement, these are further implicated in the pathogenesis of experimental allergic alveolitis.
9. Ando M, Konishi K, Yoneda R, Tamura M: Difference in the pheno-types of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic study in Japan. J Allergy Clin Immunol 1991, 87:1002-1009.
10. + T lymphocytes as such does not distinguish between sarcoidosis and extrinsic allergic alveolitis, these results suggest that the cytokine expression, predominately of the Th1 or Th2 type, is an important additional determinant of these respective disorders.
11. Yamasaki H, Kinoshita T, Ohmura T, Ando M, Soda K, Sakata T, et al.: Lowered responsiveness of bronchoalveolar lavage T lymphocytes in hypersensitivity pneumonitis. Am J Respir Cell Mol Biol 1991; 4;417-425.
12. Schuyler M, Gott K, Edwards B: Experimental hypersensitivity pneumonitis: cellular requirements. Clin Exp Immunol 1996, 105:169-175.
13. Schuyler M, Gott K, Fei R, Edwards B: Experimental hypersensitivity pneumonitis: Location of transferring cells. Lung 1998, 176:213-225. Cells capable of transfer are transiently (1 h) trapped in the lung but are much decreased in the lung by 4 days after transfer. After intratracheal challenge of recipients, there is a substantial increase in the number of pulmonary cells in animals exhibiting adoptive experimental hypersensitivity pneumonitis, but not in the control groups.
14. Denis M, Cormier Y, Laviolette M, Ghadirian E: T cells in hypersensitivity pneumonitis: effects of in vivo depletion of T cells in a mouse model. Am J Respir Cell Mol Biol 1992, 6:183-189.
15. Ito K, Yamasaki H, Onoue K, Ando M: Experimental hypersensitivity pneumonitis in mice induced by Trichosporon cutaneum: histologic and immunologic features and effect of in vivo depletion of T cell subsets. Exp Lung Res 1993, 19:631-652.
16. Gudmundsson G, Hunninghake GW: Interferon-γ is necessary for the expression of hypersensitivity pneumonitis. J Clin Invest 1997, 99:2386-2390. IFN-γ knockout mice developed minimal inflammation and no granulomas after exposure to Saccharopolyspora rectivirgula. When given replacement IFN-γ, the mice developed granulomatous inflammation in the lung. These studies show that IFN-γ is essential for the expression of hypersensitivity pneumonitis.
17. Gudmundsson G, Monick MM, Hunninghake GW: IL-12 modulates expression of hypersensitivity pneumonitis. J Immunol 1998, 161:991-999. The strain of mice that were sensitive to Saccharopolyspora rectivirgula had a significantly greater antigen-induced increase in IL-12 and IFN-γ gene expression, compared with the resistant strain. The resistant strain resembled the sensitive strain if they received IL-12 augmentation therapy at the time of antigen exposure. These results suggest that the IL-12 response to antigen may modulate, in part, the expression of HP.
18. + cell lines can adoptively transfer experimental HP.
19. Gudmundsson G, Bosch A, Davidson BL, Berg DJ, Hunninghake GW: Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice. Am J Respir Cell Mol Biol 1998, 19:812-818. When the IL-10 knockout mice were exposed to Saccharopolyspora rectivirgula, there was increased upregulation of IFN-γ, IL-1, and TNF-alpha mRNAs in the lungs of the mice. Adenovirus-mediated gene transfer of IL-10 to the liver of IL-10 knockout mice reduced the inflammation from that seen in control mice.
20. + T cell-mediated delayed hypersensitivity were reviewed.
21. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convitt J, Modlin RL, et al.: Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991, 254:279-282.
22. + T cells. J Exp Med 1996, 183:1-12.
23. + T cells into subpopulations with distinct cytokine profiles. J Immunol 1995, 155:2928-2937.
24. Sweetser MT, Morrison LA, Braciale VL, Braciale TJ: Recognition of preprocessed endogenous antigen by class I but not class II MHC-restricted T cells. Nature 1989, 342:180-182.
25. Raulf-Heimsoth M, Baur X: Pathomechanisms and pathophysiology of isocyanate-induced disease: Summary of present knowledge. Am J Ind Med 1998, 34:137-143.
26. Doherty TM: T-cell regulation of macrophage function. Curr Opin Immunol 1995, 7:400-404.
27. Steele MG, Herscowitz HB: Suppression of murine IgM, IgG, IgA and IgE antibody responses by alveolar macrophages. Immunology 1993, 80:62-67.
28. Swisher SG, Kiertscher SM, Golub SH, Holmes EC, Roth MD: Pulmonary macrophages suppress the proliferation and cytotoxicity of tumor-infiltrating lymphocytes. Am J Respir Cell Mol Biol 1993; 8: 486-492.
29. Yamasaki H, Kinoshita T, Ohmura T, Ando M, Soda K, Sakata T, et al.: Lowered responsiveness of bronchoalveolar lavage T lymphocytes in hypersensitivity pneumonitis. Am J Respir Cell Mol Biol 1991, 4:417-425.
30. Dakhama A, Israël-Assayag E, Cormier Y: Altered immuno-suppressive activity of alveolar macrophages in farmer's lung disease. Eur Respir J 1996, 9:1456-1462.
31. Israël-Assayag E, Cormier Y: Surfactant modifies the lympho-proliferative activity of macrophages in hypersensitivity pneumonitis. Am J Physiol 1997, 17:L1258-L1264.
32. Denis M: Proinflammatory cytokines in hypersensitivity pneumonitis. Am J Respir Crit Care Med 1995, 151:164-169.
33. Yoshimura T, Yuhki N, Moore SK, Appella E, Lerman MI, Leonard EJ: Human monocyte chemoattractant protein-1 (MCP-1). Full length cDNA cloning expression in mitogen-stimulated blood mononuclearphagocytes. FEBS Lett 1989, 244:487-493.
34. Matsushima K, Oppenheim JJ: Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL-1 and TNF. Cytokine 1989; 1:2-13.
35. + T cells in response to MIP-1α and MIP-1β. Science 1993, 260:355-358.
36. Schall TJ, Bacon K, Toy KJ, Goeddel DV: Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990, 347:669-671.
37. Denis M, Cormier Y, Fournier M, Tardif J, Laviolette M: Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model. Am J Respir Cell Mol Biol 1991, 5:477-483.
38. Fahey TJ III, Tracey KJ, Tekamp-Olson P, Cousens LS, Jones WG, Shires GT, et al.: Macrophage inflammation protein-1 modulates macrophage function. J Immunol 1992, 148: 2764-2769.
39. Schuyler M, Cormier Y: The diagnosis of hypersensitivity pneumonitis. Chest 1997, 111:534-536.
40. Ramirez-Venegas A, Sansores RH, Perez-Padilla R, Carrillo G, Selman M: Utility of a provocation test for diagnosis of chronic pigeon breeder's disease. Am J Respir Crit Care Med 1998, 158:862-869.
41. Yoshizawa Y, Ohtani Y, Hayakawa H, Sato A, Suga M, Ando M: Chronic hypersensitivity pneumonitis in Japan: A nationwide epidemiologic survey. J Allergy Clin Immunol 1999, 103:315-320. This report is on 36 cases of chronic hypersensitivity pneumonitis (HP), including 10 patients with summer-type HP, 5 patients with home-related HP, 7 patients with bird fancier's lung, 5 with isocyanate-induced HP, 4 patients with farmer's lung, and 5 patients with other types of chronic HP. Characteristics of each HP group-including symptoms and signs, and pulmonary function test, imaging, bronchoalveolar lavage, histologic, and immunologic findings and treatment-are reported.
42. Nakajima M, Toshiaki M, Yoshida K, Niki Y, Matsushima T: Evaluation of serum KL-6 levels in summer-type hypersensitivity pneumonitis. Nippon Kyobu Shikkan Gakkai Zasshi [Japan J Thorac Dis] 1998, 36:763-770.
43. Baumer I, Zissel G, Schlaak M, Muller-Quernheim J: Soluble intercellular adhesion molecule 1 (sICAM-1) in bronchoalveolar lavage (BAL) cell cultures and in the circulation of patients with tuberculosis, hypersensitivity pneumonitis and sarcoidosis. Eur J Med Research 1998, 3:288-299.
44. Embil J, Warren P, Yakrus M, Stark R, Corne S, Forrest D, et al.: Pulmonary illness associated with exposure to Mycobacterium-avium complex in hot tub water: Hypersensitivity pneumonitis or infection? Chest 1997, 111:813-816.
45. Pal TM, de Monchy JGR, Groothoff JW, Post D: The clinical spectrum of humidifier disease in synthetic fiber plants. Am J Ind Med 1997, 31:682-692.
46. Nishiura Y, Nakagawa-Yoshida K, Suga M, Shinoda T, Gueho E, Ando M: Assignment and serotyping of Trichosporon species, the causative agents of summer-type hypersensitivity pneumonitis. J Med Vet Mycol 1997, 35:45-52. The Trichosporon agents of summer-type HP were identified according to the new taxonomy, and T. asahii and T. mucoides appeared to be the major causative agents of the disease.
47. Ando M, Arima K, Yoneda R, Tamura M: Japanese summer-type hypersensitivity pneumonitis: geographic distribution, home environment, and clinical characteristics of 621 cases. Am Rev Respir Dis 1991, 144:765-769.
48. Yoshida K, Ando M, Sakata T, Araki S: Prevention of summer-type hypersensitivity pneumonitis: effect of elimination of Trichosporon cutaneum from the patients' homes. Arch Environ Health 1989, 44:317-322.
49. Miyajima M, Suga M, Nakagawa K, Ito K, Ando M: Effects of erythromycin on experimental extrinsic allergic alveolitis. Clin Exp Allergy 1999, 29:253-261. In murine experimental hypersensitivity pneumonitis developed by intratracheal inoculation with particulate Trichosporon mucoides, erythromycin markedly decreased neutrophils in the lung and skin lesions and myeloperoxidase in the lung, simultaneously with inhibiting intercellular adhesion molecule-1 expression. Josamycin had no effects on the model.