Influence of tumor necrosis factor-α and silibin on the cytotoxic action of α-Amanitin in rat hepatocyte culture

Toxicology and Applied Pharmacology

Volumn 158, Issue 3, 1999, Pages 253-260

  El Bahay, Claudia ^a   Gerber, Elisabeth ^a   Horbach, Martina ^a   Tran Thi, Quynh Hoa ^a   Röhrdanz, Elke ^a   Kahl, Regine ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Hepatotoxic; Silibin; Tumor necrosis factor ; amanitin

Indexed keywords

ALPHA AMANITIN; REACTIVE OXYGEN METABOLITE; SILIBININ; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; GENE EXPRESSION; LIPID PEROXIDATION; LIVER TOXICITY; MALE; MUSHROOM POISONING; NONHUMAN; PATHOGENESIS; PROTEIN SYNTHESIS INHIBITION; RAT; RNA SYNTHESIS;

EID: 0033180490     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8705     Document Type: Article

References (39)

1. Antras-Ferry J., Mahéo K., Morel F., Guillouzo A., Cillard P., Cillard J. Dexamethasone differently modulates TNF-α- and IL-1β-induced transcription of the hepatic Mn-superoxide dismutase gene. FEBS Lett. 403:1997;100-104.
2. Bartoloni F., Omer S., Giannini A., Botti P., Caramelli L., Ledda F., Peruzzi S., Zorn M. Amanita poisoning: A clinical-histopathological study of 64 cases of intoxication. Hepatogastroenterology. 32:1985;229-231.
3. Berry M. N., Friend D. S. High-yield preparation of isolated rat liver parenchymal cells. J. Cell Biol. 43:1969;506-520.
4. Bindoli A., Cavallini L., Siliorandi N. Inhibitory action of silymarin on lipid peroxide formation in rat liver mitochondria and microsomes. Biochem. Pharmacol. 26:1977;2405-2409.
5. Blazka M. E., Wilmer J. L., Holladay S. D., Wilson R. E., Luster M. I. . Toxicol. Appl. Pharmacol. 133:1995;43-52.
6. Bosisio E., Benelli C., Pirola O. Effect of the flavonolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacol. Res. 25:1992;147-154.
7. Bruccoleri A., Gallucci R., Blackshear G. P., Simeonova P., Thurman R. G., Luster M. I. Induction of early-immediate genes by tumor necrosis factor α contribute to liver repair following chemical-induced hepatotoxicity. Hepatology. 25:1997;133-141.
8. Chan Y.-L., Gutell R., Noller H. F., Wool I. G. The nucleotide sequence of a rat 18 S ribosomal ribonucleic acid gene and a proposal for the secondary structure of 18 S ribosomal ribonucleic acid. J. Biol. Chem. 259:1984;224-230.
9. Dehmlow C., Erhard J., de Groot H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology. 23:1996;749-754.
10. Draper H. H., Squires E. J., Mahmoodi H., Wu J., Agarwal S., Hadley M. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic. Biol. Med. 15:1993;353-363.
11. Faulstich H., Jahn W., Wieland T. Silybin inhibition of amatoxin uptake in the perfused rat liver. Drug Res. 30:1980;452-454.
12. Gerlach U. Lactate dehydrogenase. Bergmeyer H. U., Bergmeyer J., Großl M. Methods of Enzymatic Analysis. 1983;118-155 Verlag Chemie, Weinheim.
13. González-Amaro R., García-Monzón C., García-Buey L., Moreno-Otero R., Alonso J. L., Yagüe E., Pivel J. P., López-Cabrera Fernández-Ruiz E., Sánchez-Madrid F. Induction of tumor necrosis factor α production by human hepatocytes in chronic viral hepatitis. J. Exp. Med. 179:1994;841-848.
14. György I., Antus S., Blázovics A., Földiák G. Substituent effects in the free radical reactions of silybin: Radiation-induced oxidation of the flavonoid at neutral pH. Int. J. Radiat. Biol. 61:1992;603-609.
15. Ho Y.-S., Crapo J. D. Nucleotide sequences of cDNAs coding for rat manganese-containing superoxide dismutase. Nucleic Acids Res. 83:1987;313-317.
16. Hunt J. S., Chen H.-L., Hu X.-L., Chen T.-Y., Morrison D. C. Tumor necrosis factor-α gene expression in the tissues of normal mice. Cytokine. 4:1992;340-346.
17. Innes G. K., Fuller B. J., Hobbs K. E. Functional testing of hepatocytes following their recovery from cryopreservation. Cryobiology. 25:1988;23-30.
18. Kayama F., Yoshida T., Elwell M. R., Luster M. I. Role of tumor necrosis factor-α in cadmium-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 131:1995;224-234.
19. Kilberg M. S. Measurement of amino acid transport by hepatocytes in suspension or monolayer culture. Methods Enzymol. 173:1989;564-575.
20. Kobayashi D., Watanabe N., Yamauchi N., Tsuji N., Sato T., Niitsu Y. Endogenous tumor necrosis factor as a predictor of doxorubicin sensitivity in leukemic patients. Blood. 89:1997;2472-2479.
21. Kröncke K. D., Fricker G., Meiers P. J., Gerok W., Wieland T., Kurz G. α-Amanitin uptake into hepatocytes. J. Biol. Chem. 261:1986;12562-12567.
22. Langer, M., Vesconi, S., Constantino, D., and Busi, C.1980. Pharmacodynamics of amatoxins in human poisoning as the basis for the removal treatment. In Amanita Toxins and Poisoning (H. Faulstich, B. Kommerell, and T. Wieland, Eds.), pp. 90-95, Verlag Gerhard Witzstrock, Baden-Baden.
23. Leist M., Gantner F., Bohlinger I., Germann P. G., Tiegs G., Wendel A. Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J. Immunol. 153:1994;1778-1788.
24. Leist M., Gantner F., Naumann H., Bluethmann H., Vogt K., Brigelius-Flohé R., Nicotera P., Volk H.-D., Wendel A. Tumor necrosis factor-induced apoptosis during poisoning of mice with hepatotoxins. Gastroenterology. 112:1997;924-935.
25. Lettéron P., Labbe G., Degott C., Berson A., Fromenty B., Delaforge M., Larrey D., Pessayre D. Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Biochem. Pharmacol. 39:1990;2027-2034.
26. Lindell T. J., Weinberg F., Morris P. W., Roeder R. G., Rutter W. J. Specific inhibition of nuclear RNA polymerase II by α-amanitin. Science. 170:1970;447-449.
27. Maeda M., Watanabe N., Okamoto T., Tsuji N., Niitsu Y. Endogenous tumor necrosis factor functions as a resistant factor against adriamycin. Int. J. Cancer. 58:1994;376-379.
28. Maniatis T., Fritsch E. F., Sambrook J. Molecular Cloning: A Laboratory Manual. 1982;Cold Spring Harbor Laboratory, Cold Spring Harbor.
29. Miguez M.-P., Anundi I., Sainz-Pardo L. A., Lindros K. O. Hepatoprotective mechanism of silymarin: No evidence for involvement of cytochrome P450 2E1. Chem.-Biol. Interact. 91:1994;51-63.
30. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay. J. Immunol. Methods. 65:1983;55-63.
31. Van Remmen H., Williams M. D., Heydari A. R., Takahashi R., Chung H. Y., Yu B. P., Richardson A. Expression of genes coding for antioxidant enzymes and heat shock proteins is altered in primary cultures of rat hepatocytes. J. Cell. Physiol. 166:1996;453-460.
32. Röhrdanz E., Kahl R. Alterations of antioxidant enzyme expression in response to hydrogen peroxide. Free Radic. Biol. Med. 24:1998;27-38.
33. Sato M., Sasaki M., Hojo H. . Arch. Biochem. Biophys. 316:1995;738-744.
34. Sonnenbichler J., Zetl I. Untersuchungen zum Wirkungsmechanismus von Silibinin. V. Einfluss von Silibinin auf die Synthese ribosomaler RNA, mRNA und tRNA in Rattenlebern in vivo. Hoppe Seylers Z. Physiol. Chem. 365:1984;555-560.
35. Stirpe F., Fiume L. Studies on the pathogenesis of liver necrosis by α-amanitin. Effect of α-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei. Biochem. J. 105:1967;779-782.
36. Valenzuela A., Guerra R., Videla L. A. Antioxidant properties of the flavonoids silybin and (+)-cyanidanol-3: Comparison with butylated hydroxyanisole and butylated hydroxytoluene. Planta Med. 319:1986;438-440.
37. Wieland T. Peptides of Poisonous Amanita Mushrooms. 1986;Springer-Verlag, Heidelberg.
38. Wong G. H., Goeddel D. Induction of manganous superoxide dismutase by tumor necrosis factor: Possible protective mechanism. Science. 242:1988;941-944.
39. Zi X., Mukhtar H., Agarwal R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: Inhibition of mRNA expression of an endogenous tumor promoter TNFα Biochem. Biophys. Res. Commun. 239:1997;334-339.