Long-term results with interferon therapy in chronic type B hepatitis: A prospective randomized trial

American Journal of Gastroenterology

Volumn 94, Issue 8, 1999, Pages 2246-2250

  Mazzella, Giuseppe ^a,e   Saracco, Giorgio ^a   Festi, Davide ^a   Rosina, Floriano ^b   Marchetto, Sabrina ^b   Jaboli, Francesca ^c   Sostegni, Raffaello ^d   Pezzoli, Alessandro ^b   Azzaroli, Francesco ^a   Cancellieri, Claudio ^c   Montagnani, Marco ^c   Roda, Enrico ^c   Rizzetto, Mario ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d Division of Internal Medicine   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAN1 INTERFERON;

ADULT; AGED; ARTICLE; CLEARANCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HEPATITIS B; HUMAN; LIVER FUNCTION TEST; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROSPECTIVE STUDY; STATISTICAL ANALYSIS; TREATMENT PLANNING; VIRUS REPLICATION;

EID: 0033179742     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.1999.01300.x     Document Type: Article

References (18)

1. Alexander GJM, Pagan EA, Guarner P, et al. A controlled trial of 6 months thrice weekly lymphoblastoid Interferon versus no therapy in chronic hepatitis B virus infection. J Hepatol 1986; 3(suppl 2): 183-8.
2. Hoofnagle JH, Peters M, Müllen KD, et al. Randomized, controlled trial of recombinant human a-interferon in patients with chronic hepatitis B. Gastroenterology 1988;95:1318-25.
3. Saracco G, Mazzella G, Rosina F, et al. A controlled trial of human lymphoblastoid interferon in chronic hepatitis B in Italy. Hepatology 1989;10:336-41.
4. Korenman J, Baker B, Waggoner J, et al. Long-term remission of chronic hepatitis B after alpha-interferon therapy. Ann Intern Med 1991;! 14:628-34.
5. Lok ASF, Chung H-T, Liu VWS, et al. Long-term follow-up of chronic hepatitis B patients treated with interferon alfa. Gastroenterology 1993 ; 105:1833- 8.
6. Carreno V, Castillo I, Molina J, et al. Long-term follow-up of hepatitis B chronic carriers who responded to interferon therapy. J Hepatol 1992;15:102-6.
7. Niederau C, Heintges T, Lange S, et al. Long term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. N Engl J Med 1996;334:1422-7.
8. Fattovich G, Giustina G, Realdi G, et al. and EUROHEP. Long term outcome of heptitis Be antigen-positive patients with compensated cirrhosis treated with interferon alfa. Hepatology 1997;26:1338-42.
9. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
10. Benedetti J, Yuen K, Young L. Life tables and survival functions. In: Dixon WJ, ed. BMDP statistical software. Berkeley, CA: University of California Press, 1983:557-75.
11. Lee WM. Hepatitis B virus infection. N Engl J Med 1997; 337:1733-45.
12. Fattovich G, Giustna G, Schalm SW, et al. and the HEUROEP Study Group on Hepatitis B Virus and Cirrhosis. Occurrence of hepatocellular carcinoma and decompensation in Western European patients with cirrhosis type B. Hepatology 1995;21: 77-82.
13. Lok AS, Akarca US, Greene S. Predictive value of precore hepatitis B virus mutations in spontaneous and interferoninduced hepatitis Be antigen clearance. Hepatology 1995; 21: 19-24.
14. Fattovich G, Rugge M, Pontisso P, et al. Clinical, virological and histological outcome following seroconversion from HbeAg to anti-Hbe in chronic hepatitis type B. Hepatology 1986,6:167-72.
15. Oon CG. Long term survival following treatment of hepatocellular carcinoma in Singapore: Evaluation of Wellferon in the prophylaxis of high risk pre-cancerous conditions. Cancer Chemother Pharmacol 1992;31:S137-42.
16. Mazzella G, Accogli E, Sottili S, et al. Alpha interferon treatment may prevent hepatocellular carcinoma in HCV related liver cirrhosis. J Hepatol 1996;24:141-7.
17. Albert! A, Al Traif I, Andreone P, et al., and The International Alpha Interferon/Hepatocellular Carcinoma Group. The impact of alpha interferon on progression of cirrhosis to hepatocellular carcinoma (HCC): A retrospective cohort study of treated versus untreated patients matched for HCC risk factors. Lancet 1998;351:1535-9.
18. Chemmello L, Albert! A, Rose K, et al. Hepatitis C serotype and response to interferon therapy. N Engl J Med 1994;330: 143.