The role of Wilms' tumor genes

Journal of Medical Investigation

Volumn 46, Issue 3-4, 1999, Pages 130-140

  Hirose, Masao ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Chemoresistance; Leukemia; Rhabdoid tumor; Tumor suppressor gene; Wilms' tumor; WT

Indexed keywords

DNA BINDING PROTEIN; TRANSCRIPTION FACTOR; WT1 PROTEIN;

ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; KIDNEY TUMOR; LEUKEMIA; METABOLISM; MULTIDRUG RESISTANCE; MUTATION; NEPHROBLASTOMA; PATHOLOGY; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMALS; DNA-BINDING PROTEINS; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION; GENES, WILMS TUMOR; HEMATOPOIETIC STEM CELLS; HUMANS; KIDNEY NEOPLASMS; LEUKEMIA; MUTATION; TRANSCRIPTION FACTORS; WILMS TUMOR; WT1 PROTEINS;

EID: 0033169732     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (82)

1. Miller RW, Fraumeni JFJr, Manning MD: Association of Wilms' tumor with aniridia, hemihypertrophy and other congenital malformations. N Engl J Med 270 : 922-927, 1964
2. Turleau C, Grouchy J, Dufier JL, Phuc LH, Svhmelck PH, Rappaport R, Nihoul-Fekete C, Diebold N : Aniridia, male pseudohermaphroditism, gonadoblastoma, mental retardation, and del 11p13. Hum Genet 57 : 300-306, 1981
3. National Wilms' Tumor Study Committee: Wilms' tumor : status report. 1990. J Clin Oncol 9 : 877-887, 1991
4. Riccardi VM, Sujansky E, Smith AC, Franke U : Chromosomal imbalance in the aniridia-Wilms' tumor association : 11p interstitial deletion. Pediatrics 61 : 604-610, 1978
5. Knudson AGJr : Mutation and cancer ; statistical study of retinoblastoma. Proc Natl Acad Sci USA 68 : 820-823, 1971
6. Knudson AGJr, Strong LC : Mutation and cancer ; a model for Wilms' tumor of the kidney. J Natl Cancer Inst 48 : 313-324, 1972
7. Comings DE : A general theory of carcinogenesis. Proc Natl Acad Sci USA 70 : 3324-3328, 1973
8. Call M, Glaser H, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE : Isolation and characterization of a zinc-finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60 : 509-520, 1990
9. Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE : Alternative splicing and genomic structure of the Wilms' tumor gene WT1. Proc Natl Acad Sci USA 88 : 9618-9622, 1991
10. Pelletier J, Schalling M, Buckler AJ, Rogers A, Haber DA, Housman DE : Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes Dev 5 : 1345-1356, 1991
11. Hofmann W, Royer HD, Dresler M, Schneider S, Royer-Pokora B : Characterization of the transcriptional regulatory region of the human WT1 gene. Oncogene 8 : 3123-3132, 1993
12. Cohen HT, Bossone SA, Zhu G, McDonald GA, Sukhatme VP : Sp1 is a critical regulator of the Wilms' tumor-1 gene. J Biol Chem 272 : 2901-2913, 1997
13. Wu Y-J, Fraizer GC, Saunders GF : GATA-1 transactivates the WT1 hematopoietic specific enhancer. J Biol Chem 270 : 5944-5949, 1995
14. Fraizer GC, Wu Y-J, Hewitt SM, Maity T, Ton CCT, Huff V, Saunders GF : Transcriptional regulation of the human Wilms' tumor gene (WT1). J Biol Chem 269 : 576-588, 1994
15. Dehbi M, Pelletier J : Pax 8-mediated activation of the WT1 tumor suppressor gene. EMBO J 15 : 4297-4306, 1996
16. Dehbi M, Hiscott J, Pelletier J : Activation of the WT1 Wilms' tumor suppressor gene by NF-κB. Oncogene 16 : 2033-2039, 1998
17. Sakamoto Y, Yoshida M, Semba K, Hunter T : Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain. Oncogene 15 : 2001-2012, 1997
18. Maheswaran S, Park S, Bernard A, Morris JF, Rauscher FJ III, Hill DE, Haber DA : Physical and functional interactions between WT1 and p53 proteins. Proc Natl Acad Sci USA 90: 5100-5104, 1993
19. Duarte A, Caricasole A, Graham CF, Ward A : Wilms' tumor-suppressor protein isoforms have opposite effects of IGF2 expression in primary embryonic cells, independently of p53 genotype. Brit J Cancer 77 : 253-259, 1998
20. Smith SI, Weil D, Johnson GR, Boyd AW, Li CL : Expression of the Wilms' tumor suppressor gene, WT1, is upregulated by leukemia inhibitory factor and induces monocytic differentiation in M1 leukemic cells. Blood 91: 764-773, 1998
21. Wang Z-Y, Qui Q-Q, Gurrieri M, Huang J, Deuel TF : Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, wtl, have altered DNA binding specificity and regulate transcription in different ways. Oncogene 10 : 415-422, 1995
22. Haber DA, Buckler AJ, Glaser T, Call KM, Pelletier J, Sohn RL, Douglass EC, Housman DE : An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell 61 : 1257-1269, 1990
23. Gashler AL, Bonthron DT, Madden SL, Rauscher FJ III, Collins T, Sukhatme VP : Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms' tumor suppressor WT1. Proc Natl Acad Sci USA 89 : 10894-10988, 1992
24. Harrington MA, Konicek B, Song A, Xia X-L, Fredericks WJ, Rauscher FJ III : Inhibition of colony-stimulating growth factor-1 promoter activity by the product of the Wilms' tumor locus. J Biol Chem 268 : 21271-21275, 1993
25. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher FJ III : Repression of the insulin-like growth factor II gene by the Wilms' tumor suppressor WT1. Science 257 : 674-678, 1992
26. Werner H, Re GG, Drummond IA, Sukhatme VP, Rauscher FJ III, Sens DA, Garvin AJ, LeRoith D, Roberts CT Jr : Increased expression of the inslin-like growth factor 1 receptor gene, IGF1R, in Wilms' tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms' tumor gene product. Proc Natl Acad Sci USA 90 : 5828-5832, 1993
27. Goodyer P, Dehbi M, Torban E, Bruening W, Pelletier J : Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wt1. Oncogene 10 : 1125-1129, 1995
28. Hewitt SM, Hamada S, McDonnel TJ, Rauscher FJ III, Saunders GF : Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 55 : 5386-5389, 1995
29. Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher FJ III : Transcriptional repression mediated by the WT1 Wilms' tumor gene product. Science 253 : 1550-1553, 1991
30. Englert C, Hou X, Maheswaran S, Bennett P, Ngwu C, Re GG, Garvin AJ, Rosner MR, Haber DA : WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J 14 : 4662-4675, 1995
31. Hsu SY, Kubo M, Chun SY, Halsuka FG, Housman DE, Hsueh AJ : Wilms' tumor protein WT1 as an ovarian transcription factor : decreases in expression during follicle development and repression of inhibin-alpha gene promoter. Mol Endocrinol 9 : 1356-1366, 1995
32. Ryan G, Steele-Perkins V, Morris JF, Rauscher FJ III, Dressler GR : Repression of Pax-2 by WT1 during normal kidney development. Development 121 : 867-875, 1995
33. Dey BR, Sukhatme VP, Roberts AB, Sporn MB, Rauscher FJ III, Kim SJ : Repression of the transforming growth factor-beta gene by the Wilms' tumor suppressor WT1 gene product. Mol Endocrinol 8 : 595-602, 1994
34. Nicolas KE, Re GG, Yan YX, Garvin AI, Haber DA : WT1 induces expression of insulin-like growth factor 2 in Wilms' tumor cells. Cancer Res 55 : 4540-4543, 1995
35. Haber DA, Park S, Maheswaran S, Englert C, Re GG, Hazen-Martin DJ, Sens DA, Garvin AJ : WT1-mediated growth suppression of Wilms' tumor cells expressing a WT1 splicing variant. Science 262 : 2057-2059, 1993
36. Rupprecht HD, Drummond IA, Madden SL, Rauscher FJ III, Sukhatme VP : The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem 269 : 6198-6206, 1994
37. Prichard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gasden C, Bard J, Buckler A, Pelletier J, Housman D : The candidate Wilms' tumor gene is involved in genitourinary development. Nature 346 : 194-197, 1990
38. Buckler AJ, Pelletier J, Haber DA, Glaser T, Housman DE : Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol 11 : 1707-1712, 1991
39. Park S, Schalling M, Bernard A, Maheswaran S, Shipley GC, Roberts D, Fletcher J, Shipman R, Rheinwald J, Demetri G : The Wilms' tumor gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human methothelioma. Nat Genet 4 : 415-420, 1993
40. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenish R : WT1 is required for early kidney development. Cell 74 : 679-691, 1993
41. Silverstein GB, Horn KV, Strickland P, Roberts CTJr, Daniel CW : Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer. Proc Natl Acad Sci USA 94: 8132-8137, 1997
42. Mannens M, Slater RM, Heyting C, Bliek J, Kraker J, Coad N, de Pagter-Holthuizen P, Pearson PL : Molecular nature of genetic changes in loss of heterozygosity of chromosome 11 in Wilms' tumors. Hum Genet 81 : 41-48, 1988
43. Koufos A, Grundy P, Morgan K, Alerk KA, Hadro T, Lampkin BC, Kalbakji A, Cavenee WK : Familial Wiedemann-Beckwith syndrome and a second Wilms' tumor locus both map to 11p15.5 Am J Hum Genet 44 : 711-719, 1989
44. Ping AJ, Reeve AE, Law DJ, Young MR, Boehnke M, Feinberg AP : Genetic linkage of Beckwith-Wiedemann syndrome to 11p15. Am J Hum Genet 44 : 720-723, 1989
45. Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ : p57 KIP2, a structurally distinct member of the p21 CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes & Dev 9 : 650-662, 1995
46. Loe DW, Deeley RG, Cole SPC : Biology of the multidrug resistance-associated protein, MRP. Europ. J. Cancer 32A : 945-957, 1996
47. Hunter T, Pines J : Cyclins and cancer. II: cyclin D and CDK inhibitors come of age. Cell 79 : 573-582, 1994
48. Junien C, Henry I : Genetics of Wilms' tumor : A blend of aberant and genomic imprinting. Kidney Int 46 : 1264-1279, 1994
49. Hirose M, Yamada T, Abe T, Hirose T, Shimizu E, Yamamoto Y, Kagami S, Takano S, Yamaguchi T, Kuroda Y : Establishment and characterization of two cultured cell lines derived from malignant rhabdoid tumors of the kidney. Int J cancer 67 : 218-223, 1996
50. Beckwith JB, Palmer NF : Histological and prognosis of Wilms' tumor : Results from the First National Wilms' Tumor Study. Cancer 41 : 1937-1948, 1978
51. Morgan E, Kidd JM : Undifferentiated sarcoma of the kidney : A tumor of childhood with histopathologic and clinical characteristics distinct from Wilms' tumor. Cancer 42 : 1916-1921, 1978
52. Haas JE, Palmer NF, Weinberg AG, Beckwith JB : Ultrastructure of malignant rhabdoid tumor of the kidney : A distinctive renal tumor of children. Hum Pathol 12 : 646-657, 1981
53. Weeks DA, Beckwith JB, Mierau GW, Luckey DW : Rhabdoid tumor of kidney. A report of 111 cases from the National Wilms' Tumor study pathology center. Am J Surg Pathol 13 : 438-458, 1989
54. Englert C, Hou X, Maheswaran S, Bennett P, Ngwu C, Re GG, Garvin AJ, Rosner MR, Haber DA : WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J 14 : 4662-4675, 1995
55. Menke AL, Shvarts A, Riteco N, van Ham RCA, van der Eb AJ, Jochemsen AG : Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor. Cancer Res 57 : 1353-1363, 1997
56. Englert C, Maheswaran S, Garvin AJ, Kreidberg J, Haber DA : Induction of p21 by the Wilms' tumor suppressor gene WT1. Cancer Res 57 : 1429-1434, 1997
57. Kudoh T, Ishidate T, Moriyama M, Toyoshima K, Akiyama T : G1 phase arrest induced by Wilms' tumor protein WT1 is abrogated by cyclin/CDK complexes. Proc Natl Acad Sci USA 92 : 4517-4521, 1995
58. Little M, Wells C : A clinical overview of WT1 gene mutations. Hum Mutat 9 : 209-225, 1997
59. Moss TJ, Strauss LC, Das L, Feig SA : Secondary leukemia following successful treatment of Wilms' tumor. Am J Pediatr Hematol Oncol 11 : 158-161, 1989
60. Wang Z-Y, Qiu Q-Q, Engler KT, Deuel TF : A second transcriptionally active DNA-binding site for the Wilms' tumor gene product, WT1. Proc Natl Acad Sci USA 90 : 8896-8900, 1993
61. Haber DA, Timmers HTM, Pelletier J, Sharp PA : A dominant mutation in the tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells. Proc Natl Acad Sci USA 89 : 6010-6014, 1992
62. Miwa H, Beran M, Saunders GF : Expression of the Wilms' tumor gene (wt1) in human leukemia. Blood 90 : 1217-1225, 1997
63. Inoue K, Sugiyama H, Ogawa H, Nakagawa M, Yamagami T, Miwa H, Kita K, Hiraoka A, Masaoka T, Nasu K, Kyo T, Dohy H, Nakauchi H, Ishidate T, Akiyama T, Kishimoto T : WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood 84 : 3071-3079, 1994
64. Mauer U, Weidemann E, Karakas T, Hoelzer Z, Bergmann L: Wilms tumor gene (wt1) mRNA is equally expressed in blast cells from acute myeloid leukemia and normal CD 34+ progenitors. Blood 90 : 4230-4232, 1997
65. Phelan SA, Lindberg C, Call KM : Wilms' tumor gene, WT1, mRNA is down regulated during induction of erythroid and megakaryocytic differentiation of K562 cells. Cell Growth Differ 5 : 677-686, 1994
66. Sekiya M, Adachi M, Hinoda Y, Imai K, Yachi A : Down regulation of Wilms' tumor gene (WT1) during monocytic differentiation in HL60 cells. Blood 83 : 1876-1882. 1994
67. Patmasiriwat P, Fraizer GC, Claxton D, Kantarjian H. Saunders GF : Expression pattern of WT1 and GATA-1 in AML with chromosome 16q22 abnormalities. Leukemia 10 : 1127-1133, 1996
68. Algar EM, Khromykh T, Smith SI, Blakburn DM, Bryson GJ, Smith PJ : A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukemia cell line. Oncogene 12 : 1005-1014, 1996
69. Svedberg H, Chylicki K, Baldetorp B, Rauscher FJ III, Gullberg U : Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program. Oncogene 16 : 925-932, 1998
70. Inoue K, Tamaki H, Ogawa H, Oka Y, Soma T, Tatekawa T, Oji Y, Tsuboi A, Kim EH, Kawakami M, Akiyama T, Kishimoto T, Sugiyama H: Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells. Blood 91 : 2969-2976, 1998
71. King-Underwood L, Prichard-Jones K : Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 91 : 2961-2968, 1998
72. Thottassery JV, Zambetti GP, Arimori K, Schuetz EG, Schetz JD : p53-dependent regulation of mdrl gene expression causes selective resistance to chemotherapeutic egents. Proc Natl Acad Sci USA 94 : 11037-11042 1997
73. Pastan I, Gottesman M : Multiple drug resistance in human cancers. New Engl J Med 316 : 1288-1293, 1987
74. Tsuruo T : Mechanisms of multidrug resistance and implications for therapy. Jpn J Cancer Res 79 : 285-296, 1988
75. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AT, Kurz EU, Duncan AMV, Deeley RG : Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654, 1992
76. Dimiani D, Michieli M, Michelutti A, Geromin A, Raspsdori D, Fanin R, Savignano C, Giacca M, Pileri S, Mallardi F, Baccarani M : Expression of multidrug resistance gene (MDR-1) in human normal leukocytes. Hematologica 78 : 12-17, 1993
77. Kang YK, Zhan Z, Regis J, Robey R, Meadows B, Dickstein B, Lee JS, Otsuki T, Stetler-Stevenson M, Jaffe ES, Solomon D, Wilson WH, Fojo A, Bates S : Expression of mdr-1 in refractory lymphoma : quantitation by polymerase chain reaction and validation of the assay. Blood 15 : 1515-1524, 1995
78. Kavallaris M, Leary JA, Barrett JA, Friedlander ML : MDR1 and multidrug-associated protein (MRP) gene expression in epithelial ovarian tumors. Cancer Lett 102 : 7-16, 1996
79. Esteller M, Martines-Palones JM, Garcia A, Xercavins J, Reventos J : High rate of mdr-1 and heterogenous pattern of mrp expression without gene amplification in endometrial cancer. Int J Cancer 69 : 798-803, 1995
80. Scheffer GL, Wijingaard OLJ, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJLM, Clevers HC, Scheper RJ : The drug resistance related protein LRP is the human major vault protein. Nat Med 1 : 578-582, 1995
81. Sugawara I, Akiyama S, Scheper RJ, Itoyama S : Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR 1 and MRP. Cancer Lett 112 : 23-31, 1997
82. Hirose M, Kuroda Y : p53 may mediate mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines. Cancer Lett 129 : 165-171, 1998