High-density culture of red beet hairy roots by considering medium flow condition in a bioreactor

Chemical Engineering Science

Volumn 54, Issue 15-16, 1999, Pages 3179-3186

  Kino Oka, Masahiro ^a   Hitaka, Yoshio ^a   Taya, Masahito ^a   Tone, Setsuji ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Bioreactor design; High density culture; Liquid flow effect; Plant tissue culture; Red beet hairy roots; Shear stress

Indexed keywords

BIOREACTOR; CULTURE MEDIUM; TISSUE CULTURE;

BIOREACTORS; DENSITY (SPECIFIC GRAVITY); FLOW OF FLUIDS; GROWTH KINETICS; OXYGEN; PLANT CELL CULTURE; SHEAR STRESS; SURFACES; VELOCITY;

DISSOLVED OXYGEN CONCENTRATION; ELONGATION RATE; HIGH DENSITY CULTURE; LIQUID FLOW CONDITIONS; RADIAL FLOW REACTOR; RED BEET HAIRY ROOTS; SINGLE COLUMN REACTOR; SPECIFIC CROSS SECTIONAL AREA; SUPERFICIAL VELOCITIES; VOID FRACTIONS;

PLANTS (BOTANY);

BIOREACTOR; LIQUID FLOW; VEGETATION;

EID: 0033167266     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(98)00345-5     Document Type: Article

References (13)

1. Hamill, J.D., Parr, A.J., Rhodes, M.J.C., Robins, R.J., & Walton, N.J. (1987). New routes to plant secondary products. Bio/Technology, 5, 800-804.
2. Hilton, M.G., & Rhodes, M.J.C. (1990). Growth and hyoscyamine production of 'hairy root' cultures of Datura stramonium in a modified stirred tank reactor. Appl. Microbiol. Biotechnol., 33, 132-138.
3. Hitaka, Y., Kino-oka, M., Taya, M., & Tone, S. (1997). Effect of liquid flow on culture of red beet hairy roots in a single-column reactor. J. Chem. Engng Japan, 30, 1070-1075.
4. Kino-oka, M., Hongo, Y., Taya, M., & Tone, S. (1992). Culture of red beet hairy root in bioreactor and recovery of pigment released from the cells by repeated treatment of oxygen starvation. J. Chem. Engng Japan, 25, 490-495.
5. Kino-oka, M., Tsutsumi, S., & Tone, S. (1996). Oxygen transfer in bioreactor for culture of plant hairy roots. J. Chem. Engng Japan, 29, 531-534.
6. Kondo, O., Honda, H., Taya, M., & Kobayashi, T. (1989). Comparison of growth properties of carrot hairy root in various bioreactors. Appl. Microbiol. Biotechnol., 32, 291-294.
7. Murashige, T., & Skoog, F. (1962). A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant., 15, 473-497.
8. Ramakrishnan, D., & Curtis, W.R. (1994). Fluid dynamic studies on plant root cultures for application to bioreactor design. In: S. Furusaki, & D.D.Y. Ryu (Eds.), Advances in Plant Biotechnology: Production of Secondary Metabolites (pp. 281-305), Amsterdam: Elsevier.
9. Sim, S.J., & Chang, H.N. (1993). Increased shikonin production by hairy roots of Lithosperumum erythrorhizon in two phase bubble column reactor. Biotechnol. Lett., 15, 145-150.
10. Taya, M., Mine, K., Kino-oka, M., Tone, S., & Ichi, T. (1992). Production and release of pigments by culture of transformed hairy root of red beet. J. Ferment. Bioengng, 73, 31-36.
11. Uozumi, N., Kohketsu, K., & Kobayashi, T. (1993). Growth and kinetic parameters of Ajuga hairy root in fed-batch culture on monosaccharide medium. J. Chem. Technol. Biotechnol., 57, 155-161.
12. Yoshida, H., Mizutani, S., & Ikenaga, H. (1997). Scale-up of interleukin-6 production by BHK cells using a radial-flow reactor packed with porous glass beads. J. Ferment. Bioengng, 84, 279-281.
13. Yu, S., & Doran, P.M. (1994). Oxygen requirements and mass transfer in hairy-root culture. Biotechnol. Bioengng, 44, 880-887.