Lysosphingomyelin prevents behavioral aberrations and hippocampal neuron loss induced by the metabotropic glutamate receptor agonist quisqualate

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 23, Issue 5, 1999, Pages 877-892

  Hodgson, Deborah M ^a,b   Taylor, Anna N ^a,b   Zhang, Zhaobin ^c   Rosenberg, Abraham ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Excitotoxicity; Glutamate; Lysosphingomyelin; MAP 2; Metabotropic; Quisqualate

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMIC ACID; QUISQUALIC ACID; SPHINGOMYELIN; SPHINGOSYLPHOSPHORYLCHOLINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR DISORDER; CALCIUM CELL LEVEL; DRUG EFFECT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; RAT; SEIZURE; STROKE;

ANIMALS; BEHAVIOR, ANIMAL; DYSKINESIA, DRUG-INDUCED; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; LATERAL VENTRICLES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; PHOSPHORYLCHOLINE; QUISQUALIC ACID; RATS; RATS, INBRED F344; RECEPTORS, METABOTROPIC GLUTAMATE; SEIZURES; SPHINGOSINE;

EID: 0033167262     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(99)00047-0     Document Type: Article

References (31)

1. Berridge, M.J. (1993) Inositol trisphosphate and calcium signaling. Nature, 361, 315-325.
2. Bessho, Y., Nawa, H. and Nakanishi, S (1993) Glutamate and quisqualate regulate expression of metabotropic glutamate receptor mRNA in cultured cerebella cells. J. Neurochem. 60, 253-259.
3. Clarke, G.D. (1989) Role of excitatory amino acids in brain injury caused by ischemia, status epilepticus, and hypoglycemia, Clin. Perinatol. 16, 459-474.
4. Cockcroft, S. and Thomas, M.H (1992) Inositol-specific phospholipase C isozymes and their differential regulation by receptors. Biochem. J. 288, 1-14.
5. Congar, P., Leinekugel, X., Ben-Ari, Y. and Crepel, V. A (1997) long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation of exogenous activation of group 1 metabotropic glutamate receptors in CA1 pyramidal neurons. J. Neurosci, 17, 5366-5379.
6. Conn, P.J., and Pin, J. -P (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237.
7. Crews, F.T. and Chandler, L.J. (1993) Excitotoxicity and the neuropathology of ethanol. NIH Res. Monog. 22, 355-372.
8. Dettbarn, C., Betto, R., Salviati, G., Sabbadini, R. and Palade, P. (1995) Involvement of ryanodine receptors in sphingosylphosphorylcholine-induced calcium release from brain microsomes. Brain Res. 669, 79-85.
9. Godfrey, P.P., Wilkins, C.J., Tyler, W. and Watson, S.P. (1988) Stimulatory and inhibitory actions of excitatory amino acids on inositol phospholipid metabolism in rat cortex. Br. J. Pharmacol. 95, 131-138.
10. Hodgson, D.M., Taylor, A.N. Zhang, Z. and Rosenberg, A. (1998) Psychosine blocks quisqualate-induced glutamate excitotoxicty in hippocampal CA sector neurons. Brain Res. 802: 1-8, 1998.
11. Hollemann, M. and Heinemann, S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-80.
12. Inzuka, T., Tamura, A., Sato, S., Kirino, T., Yanagisawa, K., Toyoshima, I. and Miyatake, T. (1990) Changes in the concentrations of cerebral proteins following occlusion of the middle cerebral artery in rats. Stroke, 21, 917-9).
13. Isaacson, R.L. and Pribram, K.H. (1985) The Hippocampus. Vol VI, Plenum, New York.
14. Johnson, G.V., Litersky, J.M., and Jope, R.S. (1980) Degradation of microtubule associated protein and brain spectrin by calpain: a comparative study. J. Neurochem. 56, 1630-1635.
15. Katayama, Y., Becjker, D.P., Tamura, T. and Hovda, D.A. (1990) Massive increases in extracellular potassium and indiscriminate release of glutamate following concussive brain injury. J.Neurosurg. 73, 889-900.
16. Kitigawa, T., Matsumoto, M., Niinobe, M. Mikoshiba, K., Hata, R., Ueda, H., Handa, N., Fukunga, R., Isaka, Y., Kimura, K. and Kamada, T. (1989) Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage: Immunohistochemical investigation of dendritic damage. Neurosci. 2, 401-411.
17. Meldrum, B. and Garthwaite, J. (1990) Excitatory amino acid neurotoxicity and neurodegenerative diseases. Trends Pharmac. Sci. 11, 379-387.
18. Meyer Zu Herringdorf, D., Van Koppen, C.J. and Jakobs (1997) K.H. Molecular diversity of sphingolipid signaling. FEBS Lett. 419, 34-38.
19. Morales, M. and Fifkova, E (1992) Distribution of MAP-2 in dendritic spines and colocalization with actin. Cell Tissue Res. 256, 447-456.
20. Paxinos, G. and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates 2nd Edition, Academic Press, New York.
21. Pin, J. -P., Joly, C., Heinemann, S.F. and Bockaert, J. (1994) Domains involved in specificity of G protein activation of phospholipase C-coupled metabotropic glutamate receptors. Emboj. 13, 342-348.
22. Ritchie, T., Rosenberg, A. and Noble, E. (1992) Regulation of phosphoinositide hydrolysis in cultured astrocytes by sphingosine and psychosine. Biochem. Biophys. Res. Commun. 186, 790-795.
23. Sacaan, A.I. and Schoepp, D.D. (1992) Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage. Neurosci. Letters, 139, 77-82.
24. Schoepp, D.D., Bockaert, J. and Sladeczek, F. (1990) Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends Pharmacol. Sci. 11, 508-515.
25. Schoepp, D.D. and Conn, P.J. (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Pharmac. 14, 13-20.
26. Segelson, J.E., Lipscomb, D.C., Haun, S.E., Trapp, V.L. and Horrocks, L.A. (1995) Astroglial phosphoinositide hydrolysis during combined glucose-oxygen deprivation: role of the metabotropic glutamate receptor. J. Neurochem. 65, 1115-1123.
27. aq family of heterotrimeric G proteins in mammalian cells. J.Neurochem. 70, 1964-1972.
28. Simpson, P.B., Nahorski, S.R. and Challis, R.A.J. (1996) Agonist -evoked Ca 2+ mobilization from stores expressing inositol 1,4,5-trisphosphate receptors and ryanodine receptors in cerebellar granule cells. J. Neurochem. 67, 364-373.
29. Taylor, G.W., Merlin, L.R. and Wong, R.K.(1995) Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation. J. Neurochem. 15, 8039-8052.
30. Thomsen, C., Klitgaard, H., Sheardown, M., Jackson, H.C., Esesen, K., Jacobsen, P., Treppendahl, S.D. and Sudzac, P. (1994) (S)-4-carboxy-3-hydroxy-phenylglycine, an antagonist of metabotropic glutamate (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J. Neurochem. 62, 2492-2495.
31. Tizzano, J.P., Griffey, K.I. and Schoepp, D.D. (1995) Induction or protection of limbic seizures in mice by mGluR subtype selective agents. Neurophamacol. 34, 1063-1067.