The influence of nimodipine, nicardipine and amlodipine on the brain free fatty acid level in rats with penicillin-induced seizures

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 23, Issue 5, 1999, Pages 951-961

  Župan, Gordana ^a   Eraković, Vesna ^a   Simonić, Ante ^a   Križ, Jasna ^a   Varljen, Jadranka ^a  

^a UNIVERSITY OF RIJEKA   (Croatia)

Author keywords

Calcium channel blockers; Free fatty acids; Penicillin; Rats; Seizures

Indexed keywords

AMLODIPINE; CALCIUM CHANNEL; FATTY ACID; NICARDIPINE; NIMODIPINE; PENICILLIN G;

ANIMAL EXPERIMENT; ARTICLE; BRAIN LEVEL; CALCIUM CURRENT; CALCIUM HOMEOSTASIS; DOSE RESPONSE; DRUG EFFECT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SEIZURE;

AMLODIPINE; ANIMALS; BRAIN CHEMISTRY; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; FATTY ACIDS, NONESTERIFIED; MALE; NICARDIPINE; NIMODIPINE; PENICILLINS; RATS; RATS, WISTAR; SEIZURES;

EID: 0033167069     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(99)00038-X     Document Type: Article

References (36)

1. Alps, B. and Hass, A.R. (1985) Nicardipine and Phenytoin Prevention of Cerebral Ischemic Cell Changes in a New Rat Survival Model of Brief Four-Vessel Occlusion. Abs. Neurology 35: 141-145.
2. Bazan, N.G. and Birkle, D.L. (1987) Polyunsaturated Fatty Acids and Inositol Phospholipids at the Synapse in Neuronal Responsiveness, In: Molecular Mechanisms of Neuronal Responsiveness, Y.H. Erlich, R.H. Lenox, E. Kornecki and W.O. Berry (Eds), pp 45-68, Plenum Publishing Corporation.
3. Bazan, N.G., Birkle, D.L., Tang, W. and Sanjeeva Reddy, T. (1986) The Accumulation of Free Arachidonic Acid, Diacylglycerols, Prostaglandins, and Lipoygenase Reaction Products in the Brain During Experimental Epilepsy. Adv. Neurol. 44: 879-902.
4. Brandt, L., Saveland, H., Ljunggren, B. and Andresson, K.E. (1988) Control of Epilepsy Partialis Continuans with Intravenous Nimodipine. Report of Two Cases. J. Neurosurg. 69: 949-950.
5. Coyle, J.T. and Puttfarcken P. (1993) Oxidative stress, Glutamate, and Neurodegenerative Disorders. Science 262:689-694.
6. Choi, D.W. (1988) Calcium-Mediated Neurotoxicity: Relationship to Specific Channel Types and Role in Ischemic Damage. Trends Neurosci. 11: 465-469.
7. Costa, L.G. (1994) Cell Signaling and Neurotoxic Events. In: Principles of Neurotoxicology, L.W. Chang (Ed.), pp 475-493 , Marcel Dekker Inc., New York.
8. Danks, A.M., Hommond, D.N., Wainer, B.H., Van Buskirk, R.G. and Isaacson, R.I. (1992) Cellular Alterations Produced by the Experimental Increase in Intracellular Calcium and the Nature of Protective Effects from Pretreatment with Nimodipine. Mol. Brain Res. 16: 168-172.
9. 2+ Imagining. Drugs in Devel. 2: 165-173.
10. Dolin, S.J., Hunter, A.B., Halsey, M.J. and Little, H. J. (1988) Anticonvulsant Profile of the Dihydropyridine Calcium Channel Antagonists, Nitrendipine and Nimodipine. Eur. J. Pharm. 152: 19-27.
11. Dugan, L.L. and Choi, D.W. (1994) Excitotoxicity, Free Radicals, and Cell Membrane Changes. Ann. Neurol. 35: 17-21.
12. Edvinsson, L., Jansen, I., Olesen, J. and Tfelt-Hansen, P. (1989) Comparison of the Effects of Flunarizine and Nimodipine on Cerebral and Temporal Arteries with Comments on Their Clinical Use in Cerebrovascular Disorders. In: Cerebral Ischemia and Calcium, A. Hartman and W. Kuschinsky ( Eds.), pp 229-305 Springer-Verlag, Berlin.
13. Eraković V., Župan, G., Mršić, J., Simonić, A. and Varljen, J. (1997) The Influence of Nicardipine and Ifenprodil on the Brain Free Arachidonic Acid Level and Behavior in Hypoxia-Exposed Rats. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 21: 633-647.
14. Hogan, M., Gjedde, A. and Hakim, A.M. (1990) Nimodipine Binding in Focal Cerebral Ischemia. Stroke 21: 78-80.
15. Križ, J., Župan, G., and Simonić A. (1995) Effects of nimodipine and nicardipine on EEG activity and EEG power spectra in kainic-acid induced seizures in rats. Soc. Neurosci. Abstr., 21:202, p84.4.
16. Larkin, J.G., McKee, P.J., Blacklaw, J., Thompson, C.G., Morgan, I.C. and Brodie, M.J. (1991) Nimodipine in Refractory Epilepsy: A Placebo-Controlled, Add-on Study. Epilepsy Res. 9: 71-77.
17. Lees, G.J. (1991) Inhibition of Sodium -Potassium-ATPase: Potentially Ubiquitous Mechanism Contributing to Central Nervous System Neuropathology. Brain Res.Rev. 16: 283-300.
18. Little, H.J., Dolin, S.J., and Halsey, M.J. (1986) Calcium Channel Antagonists Decrease the Ethanol Withdrawal Syndrome. Life. Sci. 39: 2059-2069.
19. th International Symposium on Pharmacological Control of Calcium and Potassium Homeostasis. Biological, Therapeutical and Clinical Aspects, pp 33, Fundazione Giovanni Lorenzi, Firenza.
20. Meyer F.B., Cascino, G.D., Whisnant, J.P., Sharbrough, F.W., Ivnik, R.J., Gorman, D.A., Windschitl, W.L., So, E.L. and O'Fallon, W.M. (1995) Nimodipine as an Add-on Therapy for Intractible Epilepsy. Mayo Clin. Proc. 70: 623-627.
21. Mršić, J., Župan, G., Eraković, V., Simonić, A. and Varljen, J. (1997) The Influence of Nimodipine and MK-801 on the Brain Free Arachidonic Acid Level and the Learning Ability in Hypoxia-Exposed Rats. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 21: 345-358.
22. Nyakas, C., Markel, E., Bohus, B., Schuurman, T. and Luiten, P.G.M. (1990) Protective Effect of the Calcium Antagonist Nimodipine on Discrimination Learning Deficite and Impaired Retention Behavior Caused by Prenatal Nitrite Exposure in Rats. Behav. Brain Res. 38: 69-76.
23. Palmer, G.C., Stagnitto, M.L., Ray, R.K., Knowles, M.A., Harvey, R. and Garska, G.E. (1993) Anticonvulsant Properties of Calcium Channel Blockers in mice: N-methyl-D-,L-aspartate-and Bay K 8644-Induced Convulsions and Potently Blocked by the Dihydropyridines. Epilepsia. 34: 372-380.
24. Pellegrini-Giampietro, G.L., Cherci, G., Alesiani, M., Carla, V. and Maroni, F. (1988) Excitatory Amino Acid Release From Rat Hippocampal Slices as a Consequence of Free-Radical Formation. J. Neurochem 51: 1960-1963.
25. Reddy, T.S. and Bazan, N.G. (1987) Arachidonic Acid, Stearic Acid, and Diacylglicerol Accumulation Correlates with the Loss of Phosphatidylinositol 4,5-Bisphosphate in Cerebrum 2 Seconds After Electroconvulsive Shock: Complete Reversion of Changes 5 minutes After Stimulation. J. Neurosci. Res. 18 : 449-455.
26. Shimizu, T. and Wolfe, L.S. (1990) Arachidonic Acid Cascade and Signal Transduction. J. Neurochem. 55: 1-15.
27. Siesjo, B.K., Ingvar, M. and Wieloch, T. (1986) Cellular and Molecular Events Underlying Epileptic Brain Damage. Ann. N.Y. Acad. Sci. 462: 207-223.
28. Simmet, T. and Peskar, B.A. (1990) Lipoxygenase Products of Polyunsaturated Fatty Acid Metabolism in the Central Nervous System: Biosynthesis and Putative Functions. Pharmacol. Rev. 22: 667-682.
29. 5 Vascular Smooth Muscle Cells. Eur. J. Pharm. 244: 139-144.
30. Teasdale, G., Mendelow, A.D., Graham, D.I., Harper, A.M. and Mc Culloch, J. (1990) Efficacy of Nimodipine in Cerebral Ischemia and Hemorrhage. Stroke 21: 123-125.
31. Van Luijtelaar, E.L.J.M., Ates, N. and Coenen, A.M.L. (1995) Role of L-Type Calcium Channel Modulation in Nonconvulsive Epilepsy in rats. Epilepsia 36: 86.
32. Župan G., Mršić, J. and Simonić, A. (1993a) Effects of Nicardipine, Felodipine and Nifedipine on Passive Avoidance Behavior of Intact and Hypoxia-Exposed Rats. Ach. Int. Pharmacodyn. Ther. 325: 61-69.
33. Župan G., Mršić, J. and Simonić, A. (1993b) Utjecaj Amlodipina na Pasivno Izbjegavanje Kazne u Intaktnih i Hipoksiji Izloženih Štakora. Acta Fac. med. Flum. 18: 25-31.
34. Župan G., Varljen, J., Eraković, V., Mršić, J., Križ, J., Simonić, A. and Milin, Č. (1995) Accumulation Dynamics of the Brain Total Free Fatty Acids and Free Arachidonic Acid in the Models of Cerebral Hypoxia and Epilepsy in Rats. Croat. Chem. Acta 68: 485-490.
35. Župan, G., Vitezić, D., Mršić, J., Matešić, D. and Simonić, A. (1996b) Effects of Nimodipine, Felodipine and Amlodipine on Electroconvulsive Shock-Induced Amnesia in the Rat. Eur. J. Pharmacol. 310: 103-106.
36. Župan, G., Eraković, V., Mršić, J., Varljen, J., Simonić, A. and Milin, Č. (1996a) Effect of Nicardipine and Amlodipine on the Brain Free Arachidonic Level in Hypoxic Rats. Period. Biol. 98: 107-109.