Pyrrolidines bearing a quaternary α-stereogenic center. Part 1: Synthesis of analogs of ABT-418, a powerful nicotinic agonist

Tetrahedron Letters

Volumn 40, Issue 30, 1999, Pages 5495-5497

  Giard, Thierry ^a   Lasne, Marie Claire ^b   Plaquevent, Jean Christophe ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b 6 Bd du Maréchal Juin   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; NICOTINIC AGENT;

ARTICLE; CHEMICAL REACTION; CHROMATOGRAPHY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION; METHYLATION; REACTION ANALYSIS;

EID: 0033166814     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01059-X     Document Type: Article

References (13)

1. (a) Gao, Z. G.; Cui, W. Y.; Zhang, H. T.; Liu, C. G. Pharmacol. Res. 1998, 38, 101-106.
2. (b) Prendergast, M. A.; Jackson, W. J.; Terry, A. V.; Decker, M. W.; Arneric, S. P.; Buccafusco, J. J. Psychopharmacology 1998, 136, 50-58.
3. (c) Pauly, J. R. Alzheimer's Disease Review 1998, 3, 28-34.
4. For reviews, see: (a) Lin, N.-H.; Meyer, M. D. Exp. Opin. Ther. Patents 1998, 8, 991-1015.
5. (b) Holladay, M. W.; Dart, M. J.; Lynch, J. K. J. Med. Chem. 1997, 40, 4169-4194.
6. See for a review: Giard, T. Thesis, Université de Rouen, France, December 17, 1998.
7. (a) Plaquevent, J. C.; Chichaoui, I. New J. Chem. 1993, 17, 383-384.
8. (b) Plaquevent, J. C.; Chichaoui, I. Tetrahedron Lett. 1993, 34, 5287-5288.
9. (c) Plaquevent, J. C.; Chichaoui, I. Bull. Soc. Chim. Fr. 1996, 133, 369-379.
10. (a) Duhamel, L.; Poirier, J. M. J. Org. Chem. 1979, 44, 3576-3578.
11. (b) Duhamel, P.; Kotera, M. J. Org. Chem. 1982, 47, 1688-1691.
12. Elliott, R. L.; Kopecka, H.; Lin, N.-H.; He, Y.; Garvey, D. S. Synthesis, 1995, 772-774.
13. Wenkert, E.; Dave, K. G.; Haglid, F.; Lewis, R. G.; Oishi, T.; Stevens, R. V.; Terashima, M. J. Org. Chem. 1968, 33, 747-753.