Nitric oxide alters chondrocyte function by disrupting cytoskeletal signaling complexes

Osteoarthritis and Cartilage

Volumn 7, Issue 4, 1999, Pages 399-400

  Clancy, R ^a  

^a NYU HOSPITAL FOR JOINT DISEASES   (United States)

Author keywords

Chondrocyte; NO; Osteoarthritis

Indexed keywords

FIBRONECTIN; GLYCOPROTEIN; INTEGRIN; NITRIC OXIDE; PROTEOGLYCAN;

ANIMAL CELL; ARTHRITIS; CARTILAGE CELL; CATTLE; CELL COMMUNICATION; CELL CULTURE; CELL FUNCTION; CONFERENCE PAPER; CYTOSKELETON; NONHUMAN; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS;

EID: 0033166772     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1998.0223     Document Type: Conference Paper

References (10)

1. Clancy RM, Amin A, Abramson SB. The role of nitric oxide in inflammation and immunity. Arthritis Rheum 1998;41:1141-51.
2. Farrell AJ, Blake DR, Palmer RM, Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 1992;51:1219-22.
3. Weinberg JB, Granger DL, Pisetsky DS, Seidin MF, Misukonis MA, Mason SN, et al. The role of niric oxide in the pathogenesis of spontaneous murine autoimmune disease: Increased nitric oxide production and nitric oxide synthase expression in MRL-Ipr/Ipr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered ng-monomethyl-l-arginine. J Exp Med 194;179: 651-60.
4. Pelletier J-P, Jovanovic D, Fernandez JC, Geng C, Manning P, Connor JR, et al. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum 1998;41: 1275-86.
5. Van de Loo FA, Kuiper S, van Enckevort FH, Arntz OJ, van den Berg WB. Interleukin-6 ameliorates cartilage destruction during experimental arthritis: A study interleukin-6 deficient mice. Am J Pathol 1997:151:177-91.
6. Van de Loo FA, Arntz OJ, van Enckevort FH, van Lent PL, van den Berg WB. Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in nos 2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation. Arth Rheum 1998;41:634-46.
7. Johansen JS, Jensen HS, Price PA. A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid. Br J Rheum 1993;32:949-55.
8. Rediske J, Kohne C, Zhang B, Lotz M. The inducible production of nitric oxide by articular cell types. Osteoarthrits Cartilage 1994;2:199-206.
9. Clancy RM, Abramson SB. Novel synthesis of 5-nitrosoglutathione and degradation by human neutrophils. Anal Biochem 1992;204:365-71.
10. Clancy RM, Rediske J, Tang X, Nijher N, Frenkel S, Philips M, Abramson SB. Outside-in signaling in the chondrocyte: Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho a/focal adhesion kinase signaling complex. J Clin Invest 1997;100:1789-96.