Mechanisms of cell transformation induced by polyomavirus

Brazilian Journal of Medical and Biological Research

Volumn 32, Issue 7, 1999, Pages 861-865

  Oliveira, M L S ^a   Brochado, S M ^a   Sogayar, M C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Malignant transformation; Polyomavirus T antigens; Polyomavirus induced transcriptional control; Signal transduction

Indexed keywords

POLYOMAVIRUS; TUMOR VIRUS;

VIRUS T ANTIGEN;

ANIMAL; CELL TRANSFORMATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MOUSE; MUTATION; POLYOMA VIRUS; REVIEW; SIGNAL TRANSDUCTION; VIROLOGY; VIRUS INFECTION;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MICE; MUTATION; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0033162285     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1999000700010     Document Type: Article

References (46)

1. Benjamin T & Vogt PK (1990). Cell transformation by viruses. In: Fields BN & Knipe DM (Editors), Virology. 2nd edn. Raven Press Ltd., New York, 317-367.
2. Kaplan DR, Pallas DC, Morgan W, Schaffhausen B & Roberts TM (1988). Mechanisms of transformation by polyomavirus middle T antigen. Biochimica et Biophysics Acta, 948: 345-364.
3. Eckhart W (1989). Oncogenes of DNA tumor viruses: papovavirus. In: Weinberg RA (Editor), Oncogenes and the Molecular Origins of Cancer. 1st edn. Cold Spring Harbor Laboratory Press, New York, 223-238.
4. Markland W & Smith AE (1987). Mutants of polyomavirus middle-T antigen. Biochimica et Biophisica Acta, 907: 299-321.
5. Ito Y, Brocklehurst JR & Dulbecco R (1977). Virus-specific proteins in the plasma membrane of cells lytically infected or transformed by polyoma virus. Proceedings of the National Academy of Sciences, USA, 74: 4666-4670.
6. Farmerie W & Folk WR (1984). Regulation of polyomavirus transcription by large tumor antigen. Proceedings of the National Academy of Sciences, USA, 81: 6919-6923.
7. Dailey L & Basilico C (1985). Sequences in the polyomavirus DNA regulatory region involved in viral DNA replication and early gene expression. Journal of Virology, 54: 739-749.
8. Kern FG, Pellegrini S, Cowie A & Basilico C (1986). Regulation of polyomavirus late promoter activity by viral early proteins. Journal of Virology, 1: 275-285.
9. Li H, Bhattacharyya S & Prives C (1997). Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen. Journal of Virology, 71: 6479-6485.
10. Chatterjee A, Bockus BJ, Gjorup OV & Schaffhausen BS (1997). Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis. Journal of Virology, 71: 6472-6478.
11. Dyson N, Bernards R, Friend SH, Gooding LR, Hassel JA, Major EO, Pipas JM, Vandyke T & Harlow E (1990). Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. Journal of Virology, 64: 1353-1356.
12. Freund R, Bronson RT & Benjamin TL (1992). Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product. Oncogene, 7: 1979-1987.
13. Larose A, Dyson N, Sullivan M, Harlow E & Bastin M (1991). Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization. Journal of Virology, 65: 2308-2313.
14. Zheng DQ, Vayssière JL, Petit PX, LeCoeur H, Spatz A, Mignotte B & Feunteun J (1994). Apoptosis is antagonized by large T antigens in the pathway to immortalization by polyomaviruses. Oncogene, 9: 3345-3351.
15. Doherty J & Freund R (1997). Polyomavirus large T antigen overcomes p53 dependent growth arrest. Oncogens, 14: 1923-1931.
16. Mor O, Read M & Fried M (1997). p53 in polyoma virus transformed REF52 cells. Oncogene, 15: 3113-3119.
17. Campbell KS, Auger KR, Hemmings BA, Roberts TM & Pallas DC (1995). Identification of regions in polyomavirus middle T and small T antigens important for association with protein phosphatase 2A. Journal of Virology, 69: 3721-3728.
18. Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL & Roberts TM (1990). Polyoma small and middle T antigens and SV40 small T antigen form stable complexes with protein phosphatase 2A. Cell, 60: 167-176.
19. Chen MC, Redenius D, Osati-Ashtiani F & Fluck MM (1995). Enhancer-mediated role for polyomavirus MiddleT/Small T in DNA replication. Journal of Virology, 69: 326-333.
20. Liang TJ, Carmichael GG & Benjamin TL (1984). A polyoma mutant that encodes small T antigen but not middle T antigen demonstrates uncoupling of cell surface and cytoskeletal changes associated with cell transformation. Molecular and Cellular Biology, 4: 2772-2783.
21. Li M & Garcea RL (1994). Identification of the threonine phosphorylation sites on the polyomavirus major capsid protein VP1: relationship to the activity of middle T antigen. Journal of Virology, 68: 320-327.
22. Asselin C, Gelinas C & Bastin M (1983). Role of three polyoma virus early proteins in tumorigenesis. Molecular and Cellular Biology, 3: 1451-1459.
23. Treisman R, Novak U, Favaloro J & Kamen R (1981). Transformation of rat cells by an altered polyoma virus genome expressing only the middle T protein. Nature, 292: 595-600
24. Armelin MCS & Oliveira MLS (1996). Polyomavirus-induced malignant transformation: comparative analysis of wild type and mutant middle T-overexpressing cell lines. Brazilian Journal of Medical and Biological Research, 29: 1133-1140.
25. Pallas DC, Cherington V, Morgan W, DeAnda J, Kaplan D, Schaffhausen B & Roberts TM (1988). Cellular proteins that associate with the middle T and small T antigens of polyomavirus. Journal of Virology, 62: 3934-3940.
26. Campbell KS, Ogris E, Burke B, Su W, Auger KR, Druker BJ, Schaffhausen BS, Roberts TM & Pallas DC (1994). Polyoma middle tumor antigen interacts with Shc protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proceedings of the National Academy of Sciences, USA, 91: 6344-6348.
27. Su W, Liu W, Schaffhausen BS & Roberts TM (1995). Association of polyomavirus middle tumor antigen with phospholipase C - gamma 1. Journal of Biological Chemistry, 2705: 12331-12334.
28. Yi X & Freund R (1998). Deletion of proline-rich domain in polyomavirus T antigens results in virus partially defective in transformation and tumorigenesis. Virology, 248: 420-431.
29. Brewster CE, Glover HR & Dilworth SM (1997). pp60c-src binding to polyomavirus middle-T antigen (MT) requires residues 185 to 210 of the MT sequence. Journal of Virology, 71: 5512-5520.
30. Oliveira MLS, Roberts TM, Druker BJ & Armelin MCS (1998). Mapping of polyomavirus middle T domain that is responsible for AP-1 activation. Oncogene, 16: 2975-2982.
31. Cullere X, Rose P, Thathamangalam U, Chatterjee A, Mullane KP, Pallas DC, Benjamin TL, Roberts TM & Schaffhausen BS (1998). Serine 257 phosphorylation regulates association of polyomavirus middle T antigen with 14-3-3 proteins. Journal of Virology, 72: 558-563.
32. Armelin MCS, Armelin HA, Callahan MA, Cochran BH & Stiles CD (1985). New tatics for analysis of oncogenes. In: Feramisco J, Ozanne B & Stiles C (Editors), Cancer Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 195-203.
33. Dilworth SM, Brewster CEP, Jones MD, Lanfrancone L, Pelicci G & Pelicci PG (1994). Transformation by polyomavirus middle T antigen involves the binding and tyrosine phophorylation of She. Nature, 367: 87-90.
34. Rozakis-Adckock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, Schiessinger J & Pawson T (1992). Association of the She and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature, 360: 689-692.
35. Hill CS & Treisman R (1995). Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell, 80: 199-211.
36. Druker BJ, Ling LE, Cohen B, Roberts TM & Schaffhausen BS (1990). A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full and associated phosphatidylinositol kinase activity. Journal of Virology, 64: 4454-4461.
37. Whitman M, Kaplan DR, Schaffhausen B, Cantley L & Roberts TM (1985). Association of phosphatidylinositol kinase activity with polyoma middle T competent for transformation. Nature, 315: 239-242.
38. Rameh LE, Chen C-S & Cantley LC (1995). Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell, 83: 821-830.
39. Summers SA, Lipfert L & Birnbaum MJ (1998). Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner. Biochemical and Biophysical Research Communications, 256: 76-81.
40. Dahl J, Jurczak A, Cheng LA, Baker DC & Benjamin TL (1998). Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen. Journal of Virology, 72: 3221-3226.
41. Webster MA, Hutchinson JN, Rauh MJ, Muthuswamy SK, Anton M, Tortorice CG, Cardiff RD, Graham FL, Hassel JA & Miller WJ (1998). Requirement for both She and phosphatidylinositol 3′ kinase signaling pathways in polymavirus middle T-mediated mammary tumorigenesis. Molecular and Cellular Biology, 18: 2344-2359.
42. Rameh LE & Armelin MCS (1992), Down-regulation of JE and KC genes by glucocorticoids does not prevent the G0→G1 transition in Balb/3T3 cells. Molecular and Cellular Biology, 12: 4612-4621.
43. Rameh LE & Armelin MCS (1991). T antigens role in polyomavirus transformation: c-myc but not cFos or cJun expression is a target for middle T. Oncogene, 6: 1049-1056.
44. Sabapathy KT, Pepper MS, Kiefer F, Mohle-Steinlein U, Tacchini-Cottier F, Fetka I, Breier G, Risau W, Cameliet P, Montesano R & Wagner EF (1997). Polyoma middle T-induced vascular tumor formation: the role of the plasminogen activator/plasmin system. Journal of Cellular Biology, 137: 953-963.
45. Hunter T (1996). Tyrosine phosphorylation: past, present and future. Biochemical Society Transactions, 24: 307-327.
46. Kenedy AP, Sekulic A, Irvin BJ, Nilson AE, Dilworth SM & Abraham RT (1998). Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signalling pathways. Journal of Biological Chemistry, 273: 11505-11513.