Genetically manipulated animals and their use in experimental research

Annals of the Academy of Medicine Singapore

Volumn 28, Issue 4, 1999, Pages 560-564

  Ge, R ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Animal models; Gene targeting; Genetic engineering; Knockout; Transgenic

Indexed keywords

ANIMAL; BIOREACTOR; DISEASE MODEL; GENE TARGETING; GENE THERAPY; GENETICS; HUMAN; RESEARCH; REVIEW; TRANSGENIC ANIMAL; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOREACTORS; DISEASE MODELS, ANIMAL; GENE TARGETING; GENE THERAPY; HUMANS; RESEARCH; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033160134     PISSN: 03044602     EISSN: 29724066     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Jaenisch R. Germ line integration and mendelian transmission of the exogenous moloney leukemia virus. Proc Natl Acad Sci USA 1976; 73:1260-4.
2. Gordon J W, Scangos G A, Plotkin D J, Barbosa J A, Ruddle F H. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 1980; 77:7380-4.
3. Hogan B, Costantini F, Lacy E. Manipulating The Mouse Embryo. 2nd ed. USA: Cold Spring Harbor Laboratory Press, 1994.
4. Lamb B T, Gearhart J D. YAC transgenics and the study of genetics and human disease. Curr Opin Genet Dev 1995; 5:342-8.
5. Joyner A L. Gene Targeting, A Practical Approach. USA: Oxford Univ Press, 1993.
6. Vega M A. Gene Targeting. USA: CRC Press, 1995.
7. Nomura T. Practical development of genetically engineered animals as human diseases models. Lab Anim Sci 1997; 47:113-7.
8. Koike S, Taya C, Kurata T, Abe S, Ise I, Yonekawa H, et al. Transgenic mice susceptible to poliovirus. Proc Natl Acad Sci USA 1991; 88:951-5.
9. Horie H, Koike S, Kurata T, Sato-Yoshida Y, Ise I, Ota Y, et al. Transgenic mice carrying the human poliovirus receptor: New animal model for study of poliovirus neurovirulence. J Virol 1994; 68:681-8.
10. Klotman P E, Rappaport J, Ray P, Kopp J B, Franks R, Bruggeman L A, et al. Transgenic models of HIV-1. AIDS 1995; 9:313-24.
11. Skowronski J, Parks D, Mariani R. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J 1993; 12:703-13.
12. Lindemann D, Welhelm R, Renard P, Althage A, Zinkernagel R, Mous J. Severe immunodeficiency associated with a human immunodeficiency virus 1 Nef/3'-long terminal repeat transgene. J Exp Med 1994; 179:797-807.
13. Quon D, Wang Y, Catalane R, Scardina J M, Murakami K, Cordell B. Formation of beta-amyloid protein deposits in brains of transgenic mice. Nature 1991; 352:239-41.
14. Higgins L S, Holtzman D M, Rabin J, Mobley W C, Cordell B. Transgenic mouse brain histopathology resembles early Alzheimer's disease. Ann Neurol 1994; 35:598-607.
15. Higgins L S, Rodems J M, Catalane R, Quon D, Cordell B. Early Alzheimer's disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751. Proc Nat Acad Sci USA 1995; 92:4402-6.
16. Moran P M, Higgins L S, Cordell B, Moser PC. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein. Proc Natl Acad Sci USA 1995; 92:5341-5.
17. Lamb B T, Sisodia S S, Lawler A M, Slunt H H, Kitt C A, Kearns W G, et al. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nat Genet 1993; 5:22-30.
18. Pearson B E, Choi T K. Expression of the human β-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice. Proc Natl Acad Sci USA 1993; 90:10578-82.
19. Snouwaert J N, Brigman K K, Latour A N, Malouf N N, Boucher R C, Smithies O, et al. An animal model for cystic fibrosis made by gene targeting. Science 1992; 257:1083-8.
20. Dorin J R, Dickson P, Alton E W F W, Smith S N, Geddes D M, Stevenson B J, et al. Cystic fibrosis in the mouse by targeted insertional mutagenesis. Nature 1992; 359:211-5.
21. Zhou X Y, Morreau H, Rottier R, Davis D, Bonten E, Gillemans N, et al. Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells. Genes Dev 1995; 9:2623-34.
22. Kuhn R F, Schwenk M, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science 1995; 269:1427-9.
23. Agah R, Frenkel P A, French B A, Michael L H, Overbeek P A, Schneider M D. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest 1997; 100:169-79.
24. Platt J L, Bach F H. The barrier to xenotransplantation. Transplantation 1991; 52:937-47.
25. Dalmasso A P, Vercellotti G M, Fischel R J, Bolman R M, Bach F H, Platt J L. Mechanisms of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am J Pathol 1992; 140:1157-66.
26. Cozzi E, White D J G. Xenotransplantation. Curr Opin Nephrol Hypertens 1996; 5:514-8.
27. Galili U, Tibel A, Samuelsson B, Rydberg L, Groth C G. Increased anti-Gal activity in diabetic patients transplanted with fetal porcine islet cell clusters. Transplantation 1995; 59:1549-56.
28. Cotterell A H, Collins B H, Parker W, Harland R C, Platt J L. The humoral immune response in humans following cross-perfusion of porcine organs. Transplantation 1995; 60:861-8.
29. Tearly R G, Tange M J, Zannettino Z L, Katerelos M, Shinkel T A, Van Denderen B J W, et al. The α-l,3-galactosyltransferase knockout mouse: implications for Xenotransplantation. Transplantation 1996; 61:13-9.
30. Cozzi E, White D J G. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995; 1:964-6.
31. Rosengard A M, Gary N R B, Langford G A, Tucker A W, Wallwork J, White D J G. Tissue expression of human complement inhibitor, decay-accelerating factor, in transgenic pigs - a potential approach for preventing xenograft rejection. Transplantation 1995; 59:1325-33.
32. McCurry K R, Kooyman D L, Alvarado C G, Cotterell A H, Martin M J, Logan J S, et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1995; 1:423-7.
33. Velander W H, Lubon H, Drohan W N. Transgenic livestock as drug factories. Sci Am 1997; 276:70-4.
34. Blaese R M, Culver K W, Miller A D, Carter C S, Fleisher T, Clerici M, et al. T lymphocyte-directed gene therapy for ADA SCID: initial trial results after 4 years. Science 1995; 270:475-80.
35. Crystal R G. Transfer of genes to humans: early lessons and obstacles to success. Science 1995; 270:404-10.