Computational Simulation of Platelet Deposition and Activation: II. Results for Poiseuille Flow over Collagen

Annals of Biomedical Engineering

Volumn 27, Issue 4, 1999, Pages 449-458

  Sorensen, Erik N ^a,c   Burgreen, Greg W ^a,b   Wagner, William R ^a,b   Antaki, James F ^a,b  

^a University of Pittsburgh   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Fluid dynamics; Mass transport; Mathematical model; Platelets; Thrombin; Thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; COLLAGEN; HEPARIN; THROMBIN; THROMBOXANE A2;

ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL ADHESION; COMPUTER SIMULATION; DIFFUSION; DRUG EFFECT; HUMAN; MECHANICAL STRESS; METABOLISM; PHYSIOLOGY; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOSIS;

ADENOSINE DIPHOSPHATE; ANTICOAGULANTS; BLOOD PLATELETS; CELL ADHESION; COLLAGEN; COMPUTER SIMULATION; DIFFUSION; HEPARIN; HUMANS; MODELS, CARDIOVASCULAR; PLATELET ACTIVATION; STRESS, MECHANICAL; THROMBIN; THROMBOSIS; THROMBOXANE A2;

EID: 0033159465     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1114/1.201     Document Type: Article

References (15)

1. Alevriadou, B. R., J. L. Moake, N. A. Turner, Z. M. Ruggeri, B. J. Folie, M. D. Phillips, A. B. Schreiber, M. E. Hrinda, and L. V. McIntire. Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 81:1263-1276, 1993.
2. Batchelor, G. K. An Introduction to Fluid Dynamics. Cambridge: Cambridge University Press, 1967.
3. Eckstein, E. C., and F. Belgacem. Model of platelet transport in flowing blood with drift and diffusion terms. Biophys. J. 60:53-69, 1991.
4. Fogelson, A. L. Continuum models of platelet aggregation: formulation and mechanical properties. SIAM (Soc. Ind. Appl. Math.) J. Appl. Math. 52:1089-1110, 1992.
5. Folie, B. J., and L. V. McIntire. Mathematical analysis of mural thrombogenesis. Concentration profiles of platelet-activating agents and effects of viscous shear flow. Biophys. J. 56:1121-1141, 1989.
6. Hubbell, J. A., and L. V. McIntire. Visualization and analysis of mural thrombogenesis on collagen, polyurethane and nylon. Biomaterials 7:354-363, 1986.
7. Keller, K. H. Effect of fluid shear on mass transport in flowing blood. Fed. Proc. 30:1591-1599, 1971.
8. Munter, W. A., and P. D. Stein. Newtonian behavior of blood at high rates of shear. Biorheology 10:501-508, 1973.
9. Rosing, J., J. L. M. L. van Rijn, E. M. Bevers, G. van Dieijen, P. Comfurius, and R. F. A. Zwaal. The role of activated human platelets in prothrombin and factor X activation. Blood 65:319-332, 1985.
10. Sakariassen, K. S., and H. R. Baumgartner. Axial dependence of platelet-collagen interactions in flowing blood. Upstream thrombus growth impairs downstream platelet adhesion. Arteriosclerosis (Dallas) 9:33-42, 1989.
11. Sorensen, E. N., G. W. Burgreen, W. R. Wagner, and J. F. Antaki. Computational simulation of platelet deposition and activation: I. Model development and properties. Ann. Biomed. Eng. 27:436-448, 1999.
12. Turner, N. A., J. L. Moake, S. G. Kamat, A. I. Schafer, N. S. Kleiman, R. Jordan, and L. V. McIntire. Comparative real-time effects on platelet adhesion and aggregation under flowing conditions of in vivo aspirin, heparin, and monoclonal antibody fragment against glycoprotein IIb/IIIa. Circulation 91:1354-1362, 1995.
13. Wagner, W. R., and J. A. Hubbell. Local thrombin synthesis and fibrin formation in an in vitro thrombosis model result in platelet recruitment and thrombus stabilization on collagen in heparinized blood. J. Lab. Clin. Med. 116:636-650, 1989.
14. 2 in human platelet deposition on collagen. J. Lab. Clin. Med. 119:690-697, 1992.
15. Yeh, C., A. C. Calvez, and E. C. Eckstein. An estimated shape function for drift in a platelet-transport model. Biophys. J. 67:1252-1259, 1994.